Occupational Exposure Assessment

职业暴露评估

• 批准号: 7966598
• 负责人: Melissa Friesen
• 金额: $ 3.05万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7966598
• 关键词: 2,4-Dichlorophenoxyacetic Acid; Air; Aromatic Amines; Aromatic Polycyclic Hydrocarbons; Arsenic; Asbestos; Atrazine; Benzene; Biological Markers; Brain; Breast; Cadmium; Carcinogens; Case-Control Studies; Categories; Chemicals; Childhood; Chlorinated Hydrocarbons; Chromium; Classification; Cohort Studies; Cross-Sectional Studies; Data; Development; Diesel Exhaust; Disease; Dose; Dust; Electromagnetic Fields; Ewings sarcoma; Exposure to; Formaldehyde; Gasoline; Germ cell tumor; Goals; Hormonal; Immune; Larynx; Lead; Lung; Lymphatic; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of urinary bladder; Measurement; Metals; Methods; Nervous System Part; New England; Occupational; Occupational Exposure; Occupations; Pattern; Performance; Pesticides; Physical activity; Polychlorinated Biphenyls; Procedures; Questionnaires; Renal carcinoma; Reporting; Solvents; Specificity; System; Techniques; Trichloroethylene; Urine; Validation; Woman; Wood material; base; case control; cohort; design; exhaust; improved; leukemia; mathematical model; population based; response; urinary

Assessment of occupational exposures is a crucial factor in evaluating dose-response relationships and most studies conducted by the Branch have an extensive exposure assessment component. Major assessment efforts in cohort studies have involved exposures to pesticides, benzene, polycyclic aromatic hydrocarbons, and diesel exhaust fumes, and to a broad range of exposures in a cohort study of women in Shanghai and shipyard workers. Cross-sectional studies are being conducted to study the effect of benzene, trichloroethylene, and atrazine on genotoxic, immune, and hormonal parameters. In the case-control design, jobs have been evaluated for a wide variety of exposures, including solvents (including chlorinated hydrocarbons, aromatic, and other solvents), metals (arsenic, chromium, cadmium, lead), electromagnetic fields, polychlorinated biphenyls, dusts (wood dust and other types) , asbestos, formaldehyde, physical activity, nitrosoamines, polycyclic aromatic hydrocarbons, gasoline and diesel exhausts, aromatic amines, and pesticides. These exposures have been evaluated in studies of cancer of the bladder, brain, breast, lung, larynx, and the lymphatic and hemtopoietic system, and of childhood brain cancer, germ cell tumor cancer, and leukemia Ewings sarcoma and possible associations with parental occupations. Methodologic studies are also conducted to improve exposure assessment techniques and to understand exposure patterns, such as peak exposures. A study is being conducted in Shanghai to evaluate assessments made from detailed occupational questionnaires with air measurements. A report describing the exposure assessment procedures for evaluating EMF exposures in a brain cancer case-control study is underway. Reports describing the occurrences of pesticides, polychlorinated biphenyls, chlorinated and aromatic solvents, wood dust, and nitrosoamines are being prepared. Detailed questionnaires have been developed for two case-control studies: a kidney cancer study in the US and a bladder cancer study in New England. A comparison of assessments to pesticides is being compared to pesticide metabolites in the urine. Important determinants of exposure to 2,4-D are being evaluated using urinary levels. Comparisons of various exposure assessments methods are being made.

职业照射评估是评估剂量-反应关系的一个关键因素，该处进行的大多数研究都有广泛的照射评估部分。队列研究中的主要评估工作涉及杀虫剂、苯、多环芳烃和柴油废气的暴露，以及上海妇女和造船厂工人的队列研究中的广泛暴露。正在进行横断面研究，以研究苯、三氯乙烯和阿特拉津对基因毒性、免疫和激素参数的影响。在病例对照设计中，对各种暴露的工作进行了评估，包括溶剂（包括氯化烃、芳香烃和其他溶剂）、金属（砷、铬、镉、铅）、电磁场、多氯联苯、粉尘（木尘和其他类型）、石棉、甲醛、体育活动、亚硝胺、多环芳香烃、汽油和柴油废气、芳香胺和杀虫剂。这些暴露已在膀胱癌、脑癌、乳腺癌、肺癌、喉癌、淋巴和造血系统癌、儿童脑癌、生殖细胞肿瘤癌和白血病尤因斯肉瘤的研究中进行了评估，并可能与父母职业有关。还进行了方法学研究，以改进暴露评估技术并了解暴露模式，例如峰值暴露。上海正在进行一项研究，以评估详细的职业问卷和空气测量结果。一份描述在脑癌病例对照研究中评估电磁场暴露的暴露评估程序的报告正在进行中。正在编写有关农药、多氯联苯、氯化和芳香溶剂、木屑和亚硝基胺发生情况的报告。已经为两项病例对照研究制定了详细的调查问卷：美国的肾癌研究和新英格兰的膀胱癌研究。正在将对农药的评估与尿液中的农药代谢物进行比较。目前正在利用尿液水平评估暴露于2,4- d的重要决定因素。目前正在对各种暴露评估方法进行比较。