The Northwestern University Cancer Health Equity Research SPORE (NU-CHERS)

西北大学癌症健康公平研究 SPORE (NU-CHERS)

基本信息

批准号：
10265425
负责人：
MELISSA A. SIMON
金额：
$ 102.31万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265425
关键词：
Accounting Award Bioinformatics Biological Biological Markers Biometry Blood Cancer Research Project Chicago Cities Clinical Clinical Investigator Clinical Research Clinical Trials Collection Communication Communities Complement Comprehensive Cancer Center County DNA DNA Methylation Development Discipline of obstetrics Disease Progression Early Diagnosis Endometrial Carcinoma Endometrial Neoplasms Epigenetic Process Evaluation Event Expression Profiling Fostering Foundations Funding Future Galanin Genes Genomics Goals Gynecologic Gynecologic Oncology Gynecology Hospitals In Vitro Incidence Individual Infrastructure Intervention Lead Leadership Link Location Malignant Female Reproductive System Neoplasm Malignant Neoplasms Malignant neoplasm of ovary Measures Minority Minority Groups Minority Recruitment Modeling Molecular Molecular and Cellular Biology Morbidity - disease rate Organoids Outcome Participant Pathology Pathway interactions Pattern Pilot Projects Platinum Prevention Process Public Hospitals Research Research Personnel Research Project Grants Resistance Resources Science Seeds Serous Solid Tissues Translational Research United States United States National Institutes of Health Universities Vision Woman Work anticancer research base biobank black women cancer health disparity cancer therapy cancer type career development comparative cooking design ethnic minority population exome sequencing experience health disparity health equity improved in vivo infrastructure development innovation insight lens methylome methylomics mortality mutational status novel novel marker outreach patient derived xenograft model precision medicine programs racial and ethnic racial difference racial disparity repository response transcriptome sequencing translational cancer research translational pipeline translational research program translational scientist treatment response tumor

项目摘要

ABSTRACT Centered in Chicago, one of the most diverse yet segregated cities with some of the most striking health disparities in the US, this P20 feasibility and planning proposal to develop the Northwestern University Cancer Health Equity Research SPORE (NU-CHERS) will generate scientific findings and establish sustainable, collaborative, academic and community infrastructure that will serve as the foundation for a comprehensive translational cancer research program focused on gynecologic cancer health disparities. In this proposal, we set our initial translational research focus on endometrial and ovarian cancer disparities as experienced by Black women. This NU-CHERS P20 program leverages outstanding translational research capacity at Northwestern University and its NCI-designated Robert H. Lurie Comprehensive Cancer Center. Research Project 1 investigates racial disparities in endometrial cancer through tumor genomics. Findings will generate critical information that not only deepens our understanding of the biological racial differences in endometrial tumors but can be used as a predictive measure for racial differences in response to treatments. Research Project 2 focuses on racial differences in DNA methylation events in ovarian cancer which may impact response to platinum-based ovarian cancer treatment and explain the striking disparity in survival experienced by Black women. The study will define the methylomes of high-grade serous ovarian cancer in Black and White women as well as develop high-grade serous ovarian cancer-derived patient derived xenografts (PDX) and organoids from which response of these models to platinum will be assessed in vitro and in vivo. Findings will define pathways and genes regulated epigenetically, which could account for disparity in clinical outcomes and may become relevant targets for intervention. To support these projects and build a solid infrastructure for a future funded gynecologic cancer health disparities P50 SPORE, we propose two Cores. The Administrative Core (AC) is the focal point for scientific, fiscal and administrative oversight and integration. The Gynecologic Biospecimen Pathology Core (GBPC) will maintain tissue/blood repositories for current and future NU-CHERS projects, in partnership with the John H. Stroger, Jr. Hospital of Cook County to enhance the availability of minority gynecologic biospecimens available to NU-CHERS researchers. In addition, we propose a Developmental Research Program (DRP) to support NU-CHERS infrastructure development goals and pipeline of translational research excellence. The NU-CHERS P20 team is comprised of basic, translational, and clinical investigators with synergistic strengths poised to forge a lasting translational research program focused on understanding and reducing gynecologic cancer disparities.

抽象的以芝加哥为中心，是最多样化的隔离城市之一，有一些最引人注目的健康美国的差异，这项P20的可行性和计划提案，以发展西北大学癌症健康公平研究孢子（NU-CHERS）将产生科学发现并建立可持续性，协作，学术和社区基础设施将成为全面的基础转化癌症研究计划的重点是妇科癌症健康差异。在此提案中，我们设定了我们最初的翻译研究重点是黑色经历的子宫内膜和卵巢癌差异女性。这个Nu-Chers P20计划利用西北航空的出色翻译研究能力大学及其NCI指定的Robert H. Lurie综合癌症中心。研究项目1 通过肿瘤基因组学研究子宫内膜癌的种族差异。调查结果将产生关键不仅加深我们对子宫内膜肿瘤生物种族差异的理解的信息但可以用作对治疗反应的种族差异的预测措施。研究项目2 侧重于卵巢癌中DNA甲基化事件的种族差异，这可能会影响对基于铂金的卵巢癌治疗并解释了黑色经历的生存差异女性。该研究将定义黑人和白人妇女中高级浆液卵巢癌的甲基瘤以及发展高度的浆液卵巢癌衍生的患者衍生异种移植物（PDX）和类器官这些模型对铂的反应将在体外和体内评估。调查结果将定义表观遗传受调节的途径和基因，这可以解释临床结果的差异，并且可以成为干预的相关目标。支持这些项目并为未来建立坚实的基础设施资助的妇科癌症健康差异P50孢子，我们提出了两个核心。行政核心（AC）是科学，财政和行政监督和整合的焦点。妇科生物植物病理核心（GBPC）将维护当前和未来的NU-CHERS项目的组织/血液存储库，与库克县小约翰·H·斯特罗格（John H. NU-CHERS研究人员可提供妇科生物测量。此外，我们提出了一个发展研究计划（DRP）支持NU-CHERS基础设施发展目标和翻译的管道研究卓越。 Nu-Chers P20团队由基本，转化和临床研究人员组成凭借协同的优势，可以制定持久的翻译研究计划，重点是理解和减少妇科癌症差异。