Developmental Research Program

发展研究计划

• 批准号: 10265430
• 负责人: MELISSA A. SIMON
• 金额: $ 15.5万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265430
• 关键词: Address; Area; Award; Basic Science; Biological; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Complex; Comprehensive Cancer Center; Consult; Detection; Development; Diagnosis; Ensure; Evaluation; Extramural Activities; Extramural Funding Mechanisms; Faculty; Fostering; Funding; Funding Mechanisms; Future; Goals; Grant; Gynecologic; Incubators; Infrastructure; Lead; Leadership; Link; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Melissa; Mentorship; Methods; Modernization; Molecular; Pathology; Pathway interactions; Phase; Pilot Projects; Population; Principal Investigator; Process; Program Research Project Grants; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Role; Schools; Science; Scientist; Seeds; Specialized Center; Stream; Thinking; Training; Training Programs; Translational Research; Triage; Underrepresented Populations; Universities; Work; base; cancer health disparity; career; collaborative environment; community based participatory research; community clinic; design; evaluation/testing; faculty research; falls; health equity; high reward; high risk; improved; innovation; interdisciplinary collaboration; member; novel; programs; success; translational approach; translational research program; translational study

ABSTRACT The NU-CHERS Developmental Research Program (DRP) will serve as the incubator for novel, cutting edge, and competitive translational research of gynecologic cancer disparities. Centered on the theme of Contemporary Translational Approaches to Advancing Health Equity in the Detection, Diagnoses, and Treatment of Gynecologic Cancers, the DRP will identify and fund research pilot projects that utilize innovative clinical and translational research concepts and approaches that fall under DRP’s theme. These research projects will be nurtured by nearly all facets of the grant program, will be supported by ongoing career enhancement programming under the DRP, and will be well poised to seek larger-scale extramural funding or be submitted as a full research project under a P50 SPORE focused on gynecologic cancer disparities. The DRP Co-Directors will work with all areas of the overall grant program, including interacting with the Gynecologic Biospecimen Pathology and Administrative Cores for technical consult and biospecimen access and triage for all potential applicants and awardees; the Leadership Council, Internal Advisory Board, and Community Advisory Board for the review and funding of new projects; and the Leadership Council, Internal Advisory Board, and External Advisory Board for the ongoing evaluation of active funded DRP pilot projects. DRP Specific Aim 1: Through program-wide coordination, build research capacity by establishing the infrastructure, processes, and direction for a SPORE pilot funding mechanism to foster high-impact innovation in clinical and basic science research focused on gynecologic cancer disparities. A central focus of DRP award recipients will be the ability to conduct novel translational research that is high-risk high-payoff to this and future SPORE grants. DRP Specific Aim 2: Establish and support a career enhancement pipeline for early-stage and established investigators to enhance or refocus their career on translational research with a gynecologic cancer disparities focus. We will leverage and foster interdisciplinary and diverse collaborations between internal and external SPORE faculty, research project recipients, community clinic leadership, and community members. DRP Specific Aim 3: Track and evaluate the success of the DRP research projects to ensure further advancement in a full health equity P50 SPORE and other extramural funding mechanisms. We will utilize established and tested evaluation processes and methods to ensure all project teams are optimized for success in future research endeavors, with the ultimate goal of setting the stage for valuable contributions in molecular approaches to tackling gynecologic cancer disparities under a P50 SPORE.

摘要 纽彻发展研究计划(DRP)将作为创新、尖端、 以及妇科癌症差异的竞争性翻译研究。以……为主题 当代促进检测、诊断和治疗中健康公平的翻译方法 对于妇科癌症，DRP将确定并资助利用创新的临床和 属于DRP主题的翻译研究概念和方法。这些研究项目将是 得到了赠款计划几乎所有方面的支持，将得到持续的职业提升的支持 DRP下的方案编制，并将充分准备寻求更大规模的外部资金或提交为 P50孢子下的一个完整的研究项目专注于妇科癌症的差异。DRP联席董事 将与整个赠款计划的所有领域合作，包括与妇科生物医学中心的互动 为所有潜在患者提供技术咨询、生物标本获取和分类的病理学和管理核心 申请者和获奖者；领导委员会、内部咨询委员会和社区咨询委员会 审查和资助新项目；领导委员会、内部咨询委员会和外部 目前正在资助的DRP试点项目的持续评估咨询委员会。DRP具体目标1：通过 计划范围内的协调，通过建立基础设施、流程和方向来建设研究能力 建立孢子试点资助机制，促进临床和基础科学研究的高影响力创新 重点关注妇科癌症的差异。DRP获奖者的中心关注点将是进行 新的翻译研究，这是高风险，高回报的这次和未来的孢子赠款。DRP具体目标2： 为早期和成熟的调查人员建立和支持职业提升渠道，以提高 或者将他们的职业生涯重新集中在转译研究上，重点是妇科癌症差异。我们将利用 并促进内部和外部孢子学院、研究人员之间的跨学科和多样化合作 项目接受者、社区诊所领导层和社区成员。DRP具体目标3：跟踪和 评估DRP研究项目的成功，以确保在全面卫生公平方面取得进一步进展P50 孢子和其他外部资助机制。我们将利用既定的和经过测试的评估程序 以及确保所有项目团队在未来的研究工作中取得成功的优化方法，最终 为分子治疗妇科癌症的有价值贡献奠定基础的目标 P50孢子下的差异。