MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER

MRI 皮质成像:开发下一代微型人类皮质 MRI 扫描仪

基本信息

  • 批准号:
    10265466
  • 负责人:
  • 金额:
    $ 169.55万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-09-30 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

SUMMARY The overarching objective of our proposal is to bring noninvasive human brain imaging into the microscale (50-500 micron isotropic) resolution in order to create a tool for studies of neuronal circuitry and network organization in the human brain. Our breakthrough technology, MR Corticography (MRCoG), represents substantial advances over existing MRI approaches. MRCoG achieves dramatic gains in spatial and temporal resolutions by focusing several different types of coil arrays on the cerebral cortex of the live human brain. These optimized high-density receiver arrays with 128 coils also serve as a shim array and thereby obtain much higher quality imaging. High-performance magnetic field gradients will be combined with state-of-the-art pulse sequences to produce over 30-times acceleration in echo planar imaging. This will enable us to reach 0.4 mm resolution in fMRI studies of the entire cerebral cortex. This unprecedented spatial resolution in human fMRI is sufficient to identify functional activity at different depth in the cortex corresponding to different cortical layers. MRCoG will also be used to achieve 100-200 micron resolution susceptibility contrast images and this enables us to map intra-cortical axon connections and the cytoarchitecture of human cortex. With over 10 times higher resolution than current 7T scanners, MRCoG will overcome current scale limitations in imaging the function and structure of cortical layers and columns. The evaluation and refinement of MRCoG will entail using advanced computational models of brain circuitry, feedforward and feedback neuronal circuit models and computational models for decoding the brain using data from layer specific and column specific fMRI. Functional and structural MRI performed with MRCoG will generate new avenues to explore human brain circuitry at an order of magnitude higher spatial resolution, while importantly image the entire cortex rather than by current approaches (e.g. zoomed imaging) that measure only small areas of cortex. Many existing 7T MRI scanners will be able to incorporate MRCoG high-resolution technology; therefore, MRCoG can be rapidly disseminated to neuroscience research centers and used to advance medical discoveries. We will evaluate MRCoG ability to resolve currently unobservable cortex abnormalities in epilepsy and autism spectrum disorder (ASD) and to improve localization and mapping of abnormal circuitry in the brain.
总结

项目成果

期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Custom, spray coated receive coils for magnetic resonance imaging.
  • DOI:
    10.1038/s41598-021-81833-0
  • 发表时间:
    2021-01-29
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Zamarayeva AM;Gopalan K;Corea JR;Liu MZ;Pang K;Lustig M;Arias AC
  • 通讯作者:
    Arias AC
A 128-channel receive array for cortical brain imaging at 7 T.
用于 7°T 皮质脑成像的 128 通道接收阵列。
  • DOI:
    10.1002/mrm.29798
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Gruber,Bernhard;Stockmann,JasonP;Mareyam,Azma;Keil,Boris;Bilgic,Berkin;Chang,Yulin;Kazemivalipour,Ehsan;Beckett,AlexanderJS;Vu,AnT;Feinberg,DavidA;Wald,LawrenceL
  • 通讯作者:
    Wald,LawrenceL
MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation.
具有偏共振饱和度的超短 TE 下大脑的 MRI 梯度回波相位对比。
  • DOI:
    10.1016/j.neuroimage.2018.03.066
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    5.7
  • 作者:
    Wei,Hongjiang;Cao,Peng;Bischof,Antje;Henry,RolandG;Larson,PederEZ;Liu,Chunlei
  • 通讯作者:
    Liu,Chunlei
Optimization of MRI Gradient Coils With Explicit Peripheral Nerve Stimulation Constraints.
  • DOI:
    10.1109/tmi.2020.3023329
  • 发表时间:
    2021-01
  • 期刊:
  • 影响因子:
    10.6
  • 作者:
    Davids M;Guerin B;Klein V;Wald LL
  • 通讯作者:
    Wald LL
Investigating cardiac stimulation limits of MRI gradient coils using electromagnetic and electrophysiological simulations in human and canine body models.
  • DOI:
    10.1002/mrm.28472
  • 发表时间:
    2021-03
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Klein V;Davids M;Schad LR;Wald LL;Guérin B
  • 通讯作者:
    Guérin B
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

David Alan Feinberg其他文献

David Alan Feinberg的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('David Alan Feinberg', 18)}}的其他基金

MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER
MRI 皮质成像:开发下一代微型人类皮质 MRI 扫描仪
  • 批准号:
    9768463
  • 财政年份:
    2017
  • 资助金额:
    $ 169.55万
  • 项目类别:
Foundations of MRI Corticography for mesoscale organization and neuronal circuitry
中尺度组织和神经元回路的 MRI 皮质成像基础
  • 批准号:
    9206105
  • 财政年份:
    2016
  • 资助金额:
    $ 169.55万
  • 项目类别:
Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI
高加速同步多层相衬 MRI
  • 批准号:
    9142186
  • 财政年份:
    2016
  • 资助金额:
    $ 169.55万
  • 项目类别:
Foundations of MRI Corticography for mesoscale organization and neuronal circuitry
中尺度组织和神经元回路的 MRI 皮质成像基础
  • 批准号:
    9763650
  • 财政年份:
    2016
  • 资助金额:
    $ 169.55万
  • 项目类别:
Highly Accelerated Simultaneous Multi-Slice Phase Contrast MRI
高加速同步多层相衬 MRI
  • 批准号:
    9322305
  • 财政年份:
    2016
  • 资助金额:
    $ 169.55万
  • 项目类别:
HIGHLY EFFICIENT CEREBRAL PERFUSION MRI
高效脑灌注 MRI
  • 批准号:
    9043963
  • 财政年份:
    2015
  • 资助金额:
    $ 169.55万
  • 项目类别:
HIGHLY EFFICIENT CEREBRAL PERFUSION MRI
高效脑灌注 MRI
  • 批准号:
    9244859
  • 财政年份:
    2015
  • 资助金额:
    $ 169.55万
  • 项目类别:
MRI Corticography (MRCoG): Micro-scale Human Cortical Imaging
MRI 皮质成像 (MRCoG):微型人体皮质成像
  • 批准号:
    9085397
  • 财政年份:
    2014
  • 资助金额:
    $ 169.55万
  • 项目类别:
MRI Corticography (MRCoG): Micro-scale Human Cortical Imaging
MRI 皮质成像 (MRCoG):微型人体皮质成像
  • 批准号:
    8828462
  • 财政年份:
    2014
  • 资助金额:
    $ 169.55万
  • 项目类别:
fMRI of human LGN: Functional subdivisions and geniculocortical connectivity
人类 LGN 的功能磁共振成像:功能细分和膝皮质连接
  • 批准号:
    8815317
  • 财政年份:
    2014
  • 资助金额:
    $ 169.55万
  • 项目类别:

相似海外基金

Shared and Distributed Memory Parallel Pre-Conditioning and Acceleration Algorithms for "Spline- Enhanced" Spatial Discretisations
用于“样条增强”空间离散化的共享和分布式内存并行预处理和加速算法
  • 批准号:
    2907459
  • 财政年份:
    2023
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Studentship
Efficient algorithms and succinct data structures for acceleration of telescoping and related problems
用于加速伸缩及相关问题的高效算法和简洁数据结构
  • 批准号:
    RGPIN-2021-03147
  • 财政年份:
    2022
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Discovery Grants Program - Individual
Acceleration framework for training deep learning by cooperative with algorithms and computer architectures
通过与算法和计算机架构合作训练深度学习的加速框架
  • 批准号:
    21K17768
  • 财政年份:
    2021
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Efficient algorithms and succinct data structures for acceleration of telescoping and related problems
用于加速伸缩及相关问题的高效算法和简洁数据结构
  • 批准号:
    RGPIN-2021-03147
  • 财政年份:
    2021
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Discovery Grants Program - Individual
Material and Device Building Blocks for Hardware Acceleration of Machine Learning and Artificial Intelligence Algorithms
用于机器学习和人工智能算法硬件加速的材料和设备构建模块
  • 批准号:
    2004791
  • 财政年份:
    2020
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Continuing Grant
CIF: Small: Collaborative Research: Acceleration Algorithms for Large-scale Nonconvex Optimization
CIF:小型:协作研究:大规模非凸优化的加速算法
  • 批准号:
    1909291
  • 财政年份:
    2019
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Standard Grant
Acceleration of trigger algorithms with FPGAs at the LHC implemented using higher-level programming languages
使用高级编程语言在 LHC 上使用 FPGA 加速触发算法
  • 批准号:
    ST/S005560/1
  • 财政年份:
    2019
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Training Grant
CIF: Small: Collaborative Research: Acceleration Algorithms for Large-scale Nonconvex Optimization
CIF:小型:协作研究:大规模非凸优化的加速算法
  • 批准号:
    1909298
  • 财政年份:
    2019
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Standard Grant
Acceleration of trigger algorithms with FPGAs at the LHC implemented using higher-level programming languages
使用高级编程语言在 LHC 上使用 FPGA 加速触发算法
  • 批准号:
    2348748
  • 财政年份:
    2019
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Studentship
OAC Core: Small: Enabling High-fidelity Turbulent Reacting-Flow Simulations through Advanced Algorithms, Code Acceleration, and High-order Methods for Extreme-scale Computing
OAC 核心:小型:通过高级算法、代码加速和超大规模计算的高阶方法实现高保真湍流反应流模拟
  • 批准号:
    1909379
  • 财政年份:
    2019
  • 资助金额:
    $ 169.55万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了