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MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER

MRI 皮质成像：开发下一代微型人类皮质 MRI 扫描仪

基本信息

批准号：
10265466
负责人：
David Alan Feinberg
金额：
$ 169.55万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-30 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10265466
关键词：
ASD patient Acceleration Algorithms Anatomy Area Axon Behavior Brain Brain imaging Brodmann&apos s area Cell Density Cerebral cortex Clinical Cognition Computer Models Computer software Cortical Column Data Development Echo-Planar Imaging Epilepsy Evaluation Face Feedback Functional Magnetic Resonance Imaging Head Heating Human Image Injury Magnetic Resonance Imaging Magnetism Maps Measures Medical Modeling Motion Neocortex Neurons Neurosciences Neurosciences Research Performance Peripheral Nerve Stimulation Phase Physiologic pulse Pilot Projects Power Sources Predisposition Protocols documentation Recovery Research Resolution Science Shapes Signal Transduction Slice Speed Structure System Techniques Technology Three-Dimensional Imaging Time Visualization autism spectrum disorder base brain circuitry cohort contrast imaging cortex mapping data acquisition data reduction density design human imaging improved magnetic field neocortical neural circuit neuronal circuitry next generation prospective scale up temporal measurement tool

项目摘要

SUMMARY The overarching objective of our proposal is to bring noninvasive human brain imaging into the microscale (50-500 micron isotropic) resolution in order to create a tool for studies of neuronal circuitry and network organization in the human brain. Our breakthrough technology, MR Corticography (MRCoG), represents substantial advances over existing MRI approaches. MRCoG achieves dramatic gains in spatial and temporal resolutions by focusing several different types of coil arrays on the cerebral cortex of the live human brain. These optimized high-density receiver arrays with 128 coils also serve as a shim array and thereby obtain much higher quality imaging. High-performance magnetic field gradients will be combined with state-of-the-art pulse sequences to produce over 30-times acceleration in echo planar imaging. This will enable us to reach 0.4 mm resolution in fMRI studies of the entire cerebral cortex. This unprecedented spatial resolution in human fMRI is sufficient to identify functional activity at different depth in the cortex corresponding to different cortical layers. MRCoG will also be used to achieve 100-200 micron resolution susceptibility contrast images and this enables us to map intra-cortical axon connections and the cytoarchitecture of human cortex. With over 10 times higher resolution than current 7T scanners, MRCoG will overcome current scale limitations in imaging the function and structure of cortical layers and columns. The evaluation and refinement of MRCoG will entail using advanced computational models of brain circuitry, feedforward and feedback neuronal circuit models and computational models for decoding the brain using data from layer specific and column specific fMRI. Functional and structural MRI performed with MRCoG will generate new avenues to explore human brain circuitry at an order of magnitude higher spatial resolution, while importantly image the entire cortex rather than by current approaches (e.g. zoomed imaging) that measure only small areas of cortex. Many existing 7T MRI scanners will be able to incorporate MRCoG high-resolution technology; therefore, MRCoG can be rapidly disseminated to neuroscience research centers and used to advance medical discoveries. We will evaluate MRCoG ability to resolve currently unobservable cortex abnormalities in epilepsy and autism spectrum disorder (ASD) and to improve localization and mapping of abnormal circuitry in the brain.

总结

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Custom, spray coated receive coils for magnetic resonance imaging.

DOI：
10.1038/s41598-021-81833-0
发表时间：
2021-01-29
期刊：
Scientific reports
影响因子：
4.6
作者：
Zamarayeva AM;Gopalan K;Corea JR;Liu MZ;Pang K;Lustig M;Arias AC
通讯作者：
Arias AC

A 128-channel receive array for cortical brain imaging at 7 T.

用于 7°T 皮质脑成像的 128 通道接收阵列。

DOI：
10.1002/mrm.29798
发表时间：
2023
期刊：
Magnetic resonance in medicine
影响因子：
3.3
作者：
Gruber,Bernhard;Stockmann,JasonP;Mareyam,Azma;Keil,Boris;Bilgic,Berkin;Chang,Yulin;Kazemivalipour,Ehsan;Beckett,AlexanderJS;Vu,AnT;Feinberg,DavidA;Wald,LawrenceL
通讯作者：
Wald,LawrenceL

MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation.

具有偏共振饱和度的超短 TE 下大脑的 MRI 梯度回波相位对比。

DOI：
10.1016/j.neuroimage.2018.03.066
发表时间：
2018
期刊：
NeuroImage
影响因子：
5.7
作者：
Wei,Hongjiang;Cao,Peng;Bischof,Antje;Henry,RolandG;Larson,PederEZ;Liu,Chunlei
通讯作者：
Liu,Chunlei

Optimization of MRI Gradient Coils With Explicit Peripheral Nerve Stimulation Constraints.