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Development of a SARS-CoV-2 vaccine for the elderly by engineering virus-like particles with SARS-CoV-2 antigen and membrane-anchored cytokines

Development of a SARS-CoV-2 vaccine for the elderly by engineering virus-like particles with SARS-CoV-2 antigen and membrane-anchored cytokines
通过使用 SARS-CoV-2 抗原和膜锚定细胞因子设计病毒样颗粒，开发针对老年人的 SARS-CoV-2 疫苗
批准号：
10259987
负责人：
CHRISTOPHER PACK
金额：
$220.0万
依托单位：
METACLIPSE THERAPEUTICS CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
项目状态：
已结题
起止时间：
2019-08-16 至 2022-08-15
来源：
https://reporter.nih.gov/project-details/10259987
关键词：
2019-nCoVAnimal TestingAntigensDataDevelopmentElderlyEngineeringGranulocyte-Macrophage Colony-Stimulating FactorImmune responseInterleukin-12MembraneProcessProteinsVaccine DesignVaccinesVirus-like particlecytokinescale up

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中文摘要
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英文摘要
Vaccine design using SARS-CoV-2 spike protein on VLPs which contain GM-CSF and IL-12 (targeting elderly). There is data supporting the premise that including GM-CSF and IL-12 in the VLP can overcome poor immune responses in elderly. Animal testing will begin using VLP with antigen and cytokines, this process will be optimized for GMP and scale-up.
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Development of Membrane Anchored Cytokines as Novel Vaccine Adjuvants for the Elderly
Development of membrane anchored cytokines as novel vaccine adjuvants for the elderly
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