RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core

摘要 核心B：呼吸道合胞病毒到哮喘的合作临床确定、生物量监测和数据管理 研究核心 核心B被设计为临床确定和数据管理的核心。励志(婴儿期) 呼吸道合胞病毒暴露后肺部感染和哮喘的易感性)出生队列成功入选 超过1900名足月健康婴儿，并将在第一个月内跟踪他们到大约4岁 资金周期。这一核心将纵向随访延长到6-8岁，届时累积 哮喘的发病率将被定义，并包括生理测试以及额外的生物制剂，因此 直接向项目1和2提供资源。核心将协调数据以解决基本问题 通过科学项目质疑呼吸道合胞病毒致哮喘毒株在儿童哮喘中的致病作用 重点放在哮喘发病过程中病毒株和宿主的相互作用途径(项目1)，以及 特定RSV毒株引起哮喘的机制(项目2)。我们的具体目标是1) 促进对INSPIRE队列的纵向后续行动，并对项目1进行生物量监测和数据管理 和2)整合临床、生理、免疫学、微生物组和病毒测序数据 协作站点，并提供分析支持，以解决跨项目的研究问题。这个核心 组建一个由流行病学家、病毒学家、免疫学家、生物统计学家和 在队列保留、生物样品获取和处理以及数据方面经验丰富的研究人员 管理层。由于毛细支气管炎和哮喘是最常见、最严重、最急慢性的疾病 婴儿期和儿童期，是给脆弱人群带来不成比例负担的疾病， 这一核心和支持的项目将通过提高我们对RSV的了解而产生重大而持久的影响- 中介性哮喘。

ABSTRACT CORE B: RSV to Asthma Cooperative Clinical Ascertainment, Biospecimen, and Data Management Research Core Core B is designed as the clinical ascertainment and data management core. The INSPIRE (Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure) birth cohort successfully enrolled over 1900 term healthy infants and will have followed them to approximately 4 years of age during the first funding cycle. This core extends the longitudinal follow-up to age 6-8 years at which time the cumulative incidence of asthma will be defined, and include physiologic testing as well as additional biospecimens, thus providing resources directly to Projects 1 and 2. The core will coordinate the data to address the fundamental questions about the causal role of asthmagenic strains of RSV on childhood asthma through scientific projects that focus on interactive pathways of the viral strain and host on asthma development (Project 1), and the mechanisms through which specific RSV strains cause asthma (Project 2). Our specific aims are to 1) facilitate longitudinal follow-up of the INSPIRE cohort, with biospecimen and data management for Projects 1 and 2; and 2) integrate clinical, physiological, immunologic, microbiome and viral sequencing data from collaborating sites and provide analytic support to address research questions across projects. This core assembles a complementary research team of epidemiologists, virologists, immunologists, biostatisticians, and research personnel experienced in cohort retention, biospecimen acquisition and processing, and data management. As bronchiolitis and asthma are the most common, serious, acute and chronic conditions of infancy and childhood, respectively, and are diseases that disproportionately burden vulnerable populations, this core and supported projects will have major, long-lasting impact by improving our understanding of RSV- mediated asthma.