Novel approaches to control mast cell function in allergic inflammation.

控制过敏性炎症中肥大细胞功能的新方法。

• 批准号: nhmrc : GNT1127290
• 负责人: A/Pr Michele Grimbaldeston
• 金额: $ 72.34万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-approaches-control-allergic-inflammation/1347614
• 关键词: Novel; approaches; control; mast; cell

Allergic disorders are a major health problem. Driven by mast cells, the underlying inflammation is exacerbated by the ‘βc family’ of cytokines acting on the surface of these cells. We aim to characterise the ‘mast cell-βc axis’ with the view to developing new therapies based on our βc receptors blocking antibodies. This path of discovery-mechanism-translation seeks to recapitulate our previous success of taking a related antibody to Phase II clinical trials to treat patients with leukaemia.

过敏性疾病是一个主要的健康问题。在肥大细胞的驱动下，潜在的炎症被作用于这些细胞表面的细胞因子的“βc家族”加剧。我们的目标是研究“肥大细胞-βc轴”，以期开发基于我们的βc受体阻断抗体的新疗法。这种发现-机制-转化的路径试图概括我们之前成功地将相关抗体用于II期临床试验以治疗白血病患者。