Novel approaches to control mast cell function in allergic inflammation.

过敏性疾病是一个主要的健康问题。在肥大细胞的推动下，作用于这些细胞表面的？C家族细胞因子加剧了潜在的炎症。我们的目标是描述肥大细胞-C轴的特征，以期基于我们的C受体阻断抗体开发新的治疗方法。这条发现-机制-翻译的道路试图重现我们之前的成功，即在第二阶段临床试验中使用相关抗体治疗白血病患者。

Allergic disorders are a major health problem. Driven by mast cells, the underlying inflammation is exacerbated by the ‘?c family’ of cytokines acting on the surface of these cells. We aim to characterise the ‘mast cell-?c axis’ with the view to developing new therapies based on our ?c receptors blocking antibodies. This path of discovery-mechanism-translation seeks to recapitulate our previous success of taking a related antibody to Phase II clinical trials to treat patients with leukaemia.