Mast cell proteases suppress respiratory viral infections and alleric inflammation of the airways

肥大细胞蛋白酶抑制呼吸道病毒感染和气道过敏性炎症

• 批准号: nhmrc : 1004185
• 负责人: A/Pr Michele Grimbaldeston
• 金额: $ 44.38万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mast-cell-proteases-inflammation-airways/109013
• 关键词: Mast; cell; proteases; suppress; respiratory

Severe RSV infection and asthma accounts for poor quality of life in our community and current treatments have limited effects. Although the factors regulating these disorders are poorly understood, mast cells (MCs) may play important roles. We have shown MC protease-6 protects against viral infection. Here we will identify how MC and their factors are involved in the control of severe respiratory infections and allergic disease of the lung, and identify potential new ways to treat these conditions.

严重的呼吸道合胞病毒感染和哮喘是我们社区生活质量差的原因，目前的治疗效果有限。虽然调节这些疾病的因素知之甚少，肥大细胞（MCs）可能发挥重要作用。我们已经证明MC蛋白酶-6对病毒感染有保护作用。在这里，我们将确定MC及其因子如何参与严重呼吸道感染和肺部过敏性疾病的控制，并确定治疗这些疾病的潜在新方法。