The UNC Chapel Hill Superfund Research Program (UNC-SRP)

摘要：北卡罗来纳大学-教堂山超级基金研究计划 北卡罗来纳大学教堂山分校的跨学科超级基金研究项目(UNC-SRP) 将解决北卡罗来纳州(北卡罗来纳州)和全国各地社区面临的严重公共卫生挑战 与无机砷(IAS)有关。UNC-SRP将IAS列为重点污染物，因为它具有很高的相关性 北卡罗来纳州和美国暴露在不安全水平下的数百万人。在北卡罗来纳州，污染来自两个地源 污染源和工业活动(如超级基金地点和火山灰污染)污染了成千上万的私人 威尔斯。据估计，北卡罗来纳州约有300万人，占该州人口的三分之一，饮用来自 私人油井，IAS最高可达800 ppb。这些人口主要分布在北卡罗来纳州的农村地区 确立了环境正义的条件。此外，IAS污染在全州范围内产生反响，并 与地方和全国相关的。与公共健康风险有关，暴露于IAS的风险已被确定为 与代谢功能障碍/糖尿病相关。在对驱动因素的认识上存在着显著的差距 IAS导致的糖尿病风险。识别这些因素将有助于小说的发展 减少国际会计准则相关糖尿病以及其他相关疾病患病率的解决办法/干预措施 暴露在IAS上。我们独特的科学主题是“确定新的方法来减少IAS的暴露和 从疾病的角度阐明IAS引起的代谢功能障碍的机制 预防。“我们解决这个问题有三个目标：(1)发现生物学机制和易感因素 潜在的IAS相关代谢功能障碍/糖尿病；(2)开发新方法和技术以 预测IAS污染，减少IAS暴露；(3)将UNC-SRP的科学转化为关键 北卡罗来纳州和更大的SRP计划中的利益相关者，并与弱势社区接触。UNC-SRP包括 五个研究项目。项目1-3使用了跨越体外和体内模型的高度翻译的技术，以及 让人类了解IA诱发糖尿病的机制。项目4-5提高了预测能力 私人饮水井中的IAS污染和强化去除IAS的创新方法。具有相关性 对于国家SRP计划，我们将与费尔法克斯圣伍德治疗者超级基金网站的现场经理合作。 五个核心包括管理核心、社区参与核心、数据管理和分析 核心(DMAC)、研究经验和培训协调核心(RETCC)以及化学和分析 核心(CAC)。这些核心有助于管理、社区与我们的合作伙伴Clean Water 北卡罗来纳州和Winyah Rivers基金会，数据管理和分析，培训和化学分析。总而言之， UNC-SRP的任务是为减少IAS和预防疾病开发新的解决方案 机械性和翻译性研究，最终为监管和超级基金网站清理工作提供信息。

ABSTRACT: THE UNC-CHAPEL HILL SUPERFUND RESEARCH PROGRAM The interdisciplinary Superfund Research Program at the University of North Carolina at Chapel Hill (UNC-SRP) will address serious public health challenges faced by communities in North Carolina (NC) and across the nation related to inorganic arsenic (iAs). The UNC-SRP prioritizes iAs as the focus contaminant as it is highly relevant to millions in NC and the US exposed to unsafe levels. In NC, contamination is derived from both geogenic sources and industrial activities (e.g. superfund sites and coal ash contamination) polluting thousands of private wells. An estimated ~3 million individuals in NC, representing one third of the state’s population, drink water from private wells, with iAs ranging up to 800 ppb. These populations are largely located in the rural areas of NC with established environmental justice conditions. Moreover, iAs contamination reverberates across the state and is locally and nationally-relevant. Related to public health risk, exposure to iAs has been established to be associated with metabolic dysfunction/diabetes. There is a significant gap in the knowledge of factors that drive iAs-induced diabetes risk. The identification of these factors would facilitate development of novel solutions/interventions to reduce the prevalence of iAs-associated diabetes, as well as other diseases associated with iAs exposure. Our unique scientific theme is “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” We address this with three aims: (1) Discover biological mechanisms and susceptibility factors underlying iAs-associated metabolic dysfunction/diabetes; (2) Develop novel methods and technologies to predict iAs contamination and reduce iAs exposure; (3) Translate the science of the UNC-SRP to key stakeholders in NC and the larger SRP program, and engage vulnerable communities. The UNC-SRP comprises five research projects. Projects 1-3 use highly translational techniques spanning in vitro and in vivo models, and human populations to understand mechanisms of iA-induced diabetes. Projects 4-5 advance the ability to predict iAs contamination in private drinking wells and innovative methods for enhanced removal of iAs. With relevance to the national SRP program, we will work with site managers at the Fairfax St. Wood Treaters Superfund site. Five Cores include the Administrative Core, the Community Engagement Core, Data management and Analysis Core (DMAC), Research Experience and Training Coordination Core (RETCC), and Chemistry and Analysis Core (CAC). These Cores facilitate administration, community engagement with our partners Clean Water for NC and the Winyah Rivers Foundation, data management and analysis, training, and chemical analyses. In sum, the UNC-SRP mission is to develop new solutions for iAs reduction and disease prevention through mechanistic and translational research to ultimately inform regulation and Superfund site cleanup efforts.