Haplotype-resolved genome assemblies and chromosomal rearrangements in arboviral vector Aedes albopictus
Haplotype-resolved genome assemblies and chromosomal rearrangements in arboviral vector Aedes albopictus
批准号:
10573961
负责人:
Maria Sharakhova
金额:
$22.71万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-11-08 至 2024-10-31
关键词:
AedesAmericasAnopheles GenusAntarcticaArbovirusesAsiaAsianBiologicalBiologyBreedingChikungunya feverChineseChromosomal RearrangementChromosome inversionChromosomesClimateCountryCulicidaeDNA ProbesDangerousnessDengueDengue FeverDevelopmentDiapauseDiseaseDisease OutbreaksEnvironmentEpidemicEpidemiologyEuropeFluorescent in Situ HybridizationFranceGenesGeneticGenetic studyGenomeGenome MappingsGenomicsGeographic LocationsGoalsGrantHaplotypesHealthHi-CHybridsInfectionInvadedItalyLaboratoriesMapsMeasuresMethodsMexicoMitotic ChromosomeMosquito ControlMosquito-borne infectious diseaseNorth AmericaPanamaParentsPhenotypePopulationPublic HealthQuantitative Trait LociReportingSouth AmericanSoutheastern AsiaSouthern EuropeSpainTechnologyTestingTigersUnited States National Institutes of HealthVariantZIKAarboviral diseasechikungunyaclimate zonecontigdisease transmissiongenome-wideimprovedmalenanoporenew technologyphotoperiodicityphysical mappingpreventreference genomescaffoldsuccesstraittransmission processvectorvector controlzika fever
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
The Asian tiger mosquito Aedes albopictus is native to Southeast Asia but in a few decades this species
expanded its range to all continents except Antarctica. Aedes albopictus is capable of transmitting multiple
arboviruses including dengue—the leading arboviral disease of 21st century—Chikungunya, and Zika—an
emerging health threats for the world. Because of its remarkable ability to develop a photoperiodic diapause in
the temperate climate, Ae. albopictus has the potential to spread these dangerous diseases further north. This
project will develop haplotype-resolved chromosome-scale genome assemblies for multiple strains of Ae.
albopictus and will test if adaptations to the temperate climate are associated with chromosomal
rearrangements in this mosquito. Toward this end, we propose the following specific aims: 1) develop a
haplotype-resolved chromosome-scale genome assemblies for four strains of Ae. albopictus including
the Foshan strain; 2) improve the physical genome map for the Foshan strain of Ae. albopictus; and 3)
identify chromosomal rearrangements in different populations of Ae. albopictus world-wide. Our long-
term goal is to understand the genetic basis of the incredible phenotypic plasticity of Ae. albopictus that helps
this mosquito to rapidly spread around the globe. We envision that the availability of the high-quality reference
genome assemblies for multiple strains of Ae. albopictus will stimulate further genetic studies aimed at
preventing mosquito-borne disease transmission.
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会议论文
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资助金额:$25.14万
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Chromosome-based genome assembly for Culex quinquefasciatus
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批准号:8604136
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资助金额:$19.89万
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财政年份:2013
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负责人:Maria Sharakhova
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依托单位:
Physical mapping of Aedes aegypti genome
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批准号:8137887
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项目类别:
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资助金额:$22.75万
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财政年份:2010
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负责人:Maria Sharakhova
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依托单位:
Physical mapping of Aedes aegypti genome
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批准号:7871634
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项目类别:
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资助金额:$20.52万
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财政年份:2010
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依托单位:
海外基金