Haplotype-resolved genome assemblies and chromosomal rearrangements in arboviral vector Aedes albopictus
虫媒病毒载体白纹伊蚊中单倍型解析的基因组组装和染色体重排
基本信息
- 批准号:10573961
- 负责人:
- 金额:$ 22.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-11-08 至 2024-10-31
- 项目状态:已结题
- 来源:
- 关键词:AedesAmericasAnopheles GenusAntarcticaArbovirusesAsiaAsianBiologicalBiologyBreedingChikungunya feverChineseChromosomal RearrangementChromosome inversionChromosomesClimateCountryCulicidaeDNA ProbesDangerousnessDengueDengue FeverDevelopmentDiapauseDiseaseDisease OutbreaksEnvironmentEpidemicEpidemiologyEuropeFluorescent in Situ HybridizationFranceGenesGeneticGenetic studyGenomeGenome MappingsGenomicsGeographic LocationsGoalsGrantHaplotypesHealthHi-CHybridsInfectionInvadedItalyLaboratoriesMapsMeasuresMethodsMexicoMitotic ChromosomeMosquito ControlMosquito-borne infectious diseaseNorth AmericaPanamaParentsPhenotypePopulationPublic HealthQuantitative Trait LociReportingSouth AmericanSoutheastern AsiaSouthern EuropeSpainTechnologyTestingTigersUnited States National Institutes of HealthVariantZIKAarboviral diseasechikungunyaclimate zonecontigdisease transmissiongenome-wideimprovedmalenanoporenew technologyphotoperiodicityphysical mappingpreventreference genomescaffoldsuccesstraittransmission processvectorvector controlzika fever
项目摘要
PROJECT SUMMARY
The Asian tiger mosquito Aedes albopictus is native to Southeast Asia but in a few decades this species
expanded its range to all continents except Antarctica. Aedes albopictus is capable of transmitting multiple
arboviruses including dengue—the leading arboviral disease of 21st century—Chikungunya, and Zika—an
emerging health threats for the world. Because of its remarkable ability to develop a photoperiodic diapause in
the temperate climate, Ae. albopictus has the potential to spread these dangerous diseases further north. This
project will develop haplotype-resolved chromosome-scale genome assemblies for multiple strains of Ae.
albopictus and will test if adaptations to the temperate climate are associated with chromosomal
rearrangements in this mosquito. Toward this end, we propose the following specific aims: 1) develop a
haplotype-resolved chromosome-scale genome assemblies for four strains of Ae. albopictus including
the Foshan strain; 2) improve the physical genome map for the Foshan strain of Ae. albopictus; and 3)
identify chromosomal rearrangements in different populations of Ae. albopictus world-wide. Our long-
term goal is to understand the genetic basis of the incredible phenotypic plasticity of Ae. albopictus that helps
this mosquito to rapidly spread around the globe. We envision that the availability of the high-quality reference
genome assemblies for multiple strains of Ae. albopictus will stimulate further genetic studies aimed at
preventing mosquito-borne disease transmission.
项目摘要
亚洲虎蚊白纹伊蚊原产于东南亚,但几十年后,
它的范围扩大到除南极洲以外的所有大陆。白纹伊蚊能够传播多种
虫媒病毒,包括登革热-21世纪的主要虫媒病毒疾病-基孔肯雅病毒和寨卡病毒
对世界的健康威胁。由于其显着的能力,发展一个光周期滞育,
温带气候,Ae.白纹伊蚊有可能将这些危险的疾病传播到更北的地方。这
该项目将为多种Ae菌株开发单倍型分辨的染色体规模基因组组装。
白纹伊蚊,并将测试是否适应温带气候与染色体
重新排列。为此,我们提出以下具体目标:1)发展一个
四种Ae菌株的单倍型分辨染色体规模基因组组装。白纹伊蚊,包括
佛山株; 2)改进Ae.白纹伊蚊;以及3)
鉴定不同群体Ae中染色体重排。白纹伊蚊在世界范围内我们长久以来-
长期目标是了解令人难以置信的表型可塑性的遗传基础。白纹伊蚊有助于
这种蚊子在地球仪迅速传播。我们设想,高质量的参考资料的可用性
多株Ae.白纹伊蚊将刺激进一步的基因研究,
预防蚊媒疾病传播。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Maria Sharakhova其他文献
Maria Sharakhova的其他文献
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{{ truncateString('Maria Sharakhova', 18)}}的其他基金
Chromosomal rearrangements in arboviral vector Aedes aegypti
虫媒病毒载体埃及伊蚊的染色体重排
- 批准号:
9974917 - 财政年份:2020
- 资助金额:
$ 22.71万 - 项目类别:
Chromosome scale genome assemblies for Culex pipiens mosquitoes
淡色库蚊的染色体规模基因组组装
- 批准号:
10302318 - 财政年份:2020
- 资助金额:
$ 22.71万 - 项目类别:
Improving the reference genome assembly for the dengue fever vector Aedes aegypti
改进登革热载体埃及伊蚊的参考基因组组装
- 批准号:
9017188 - 财政年份:2016
- 资助金额:
$ 22.71万 - 项目类别:
Chromosome-based genome assembly for Culex quinquefasciatus
基于染色体的致倦库蚊基因组组装
- 批准号:
8511874 - 财政年份:2013
- 资助金额:
$ 22.71万 - 项目类别:
Chromosome-based genome assembly for Culex quinquefasciatus
基于染色体的致倦库蚊基因组组装
- 批准号:
8604136 - 财政年份:2013
- 资助金额:
$ 22.71万 - 项目类别:
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