Imaging Core

成像核心

• 批准号: 10573152
• 负责人: Jianhang Jia
• 金额: $ 13.78万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573152
• 关键词: Aging; Animal Disease Models; Area; Award; Bioinformatics; Bioluminescence; Biomedical Research; Biometry; Cancer Center; Centers of Research Excellence; Clinical; Complex; Computer software; Consult; Consultations; Data; Dedications; Development; Disease Progression; Distant; Equipment; Evaluation; Experimental Designs; Extramural Activities; Faculty; Floor; Fluorescence; Goals; Human Resources; Image; Imaging Device; Imaging Techniques; Individual; Infrastructure; Kentucky; Laboratories; Laboratory Research; Link; Malignant Neoplasms; Medicine; Metabolic; Metabolism; Methodology; Methods; Microscope; Mission; Monitor; Mus; National Institute of General Medical Sciences; Neoplasm Metastasis; Organ; Pathology; Phase; Pilot Projects; Positioning Attribute; Productivity; Proteins; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Role; Sampling; Scientist; Services; Site; Slide; System; Tissues; Training; Transfection; Universities; Work; advanced analytics; analytical tool; animal facility; anticancer research; cancer therapy; cell motility; cost effective; design; digital; flexibility; imaging capabilities; imaging modality; imaging study; imaging system; in vivo; in vivo imaging; in vivo imaging system; instrument; metabolomics; multidisciplinary; novel; optical imaging; programs; skills; success; treatment response; tumor initiation; tumor metabolism; tumorigenesis

PROJECT SUMMARY The Imaging Core of the Center for Cancer and Metabolism (CCM) is the technical service and support core for CCM project research laboratories and pilot project recipients. The integrated services of the Core range from the imaging capabilities of simple microscopes to imaging analysis by sophisticated and advanced imaging methodologies. The Imaging Core personnel assist users to operate the instruments and analyze imaging data. The Core provides advice for the current PIs in this Center of Biomedical Research Excellence (COBRE) application to use the Imaging Core for their specific studies. The Imaging Core has provided tremendous help to the projects in Phase I of COBRE support and will continue to make its services readily available and easily accessible to all COBRE laboratories in order to generate high quality data. Toward the goals of providing efficient and high-quality imaging services and of establishing a robust imaging infrastructure within the CCM, we have added new features and new imaging systems to the Core. Our specific aims are: 1) to provide project-specific training and consultation for COBRE investigators; 2) to develop and adapt state-of- the art imaging techniques to enhance the research of early-stage and pilot project investigators; and 3) to develop and implement new methods, to enhance CCM imaging services and make such services available to COBRE and non-COBRE users. This Core will provide an easily accessible facility where investigators can evaluate their tissue and/or cellular samples using various types of imaging systems. Dr. Jianhang Jia, the Director of the Imaging Core, is a highly productive investigator who has successfully obtained substantial extramural research support including an NIGMS Maximizing Investigators' Research Award (MIRA) (R35) award for established investigators that relies extensively on sophisticated imaging capabilities. He has worked closely with all graduated COBRE PIs, making significant contributions to their successes in obtaining independent research support. Dr. Jia has guided the development of the four CCM research projects in this Phase II application, and he will continue to advise CCM investigators on the design of experiments that use imaging modalities.

项目摘要 癌症和代谢中心（CCM）的影像核心是技术服务和支持核心 供CCM项目研究实验室和试点项目接受者使用。核心系列的综合服务 从简单显微镜的成像能力到复杂和先进的成像分析， 成像方法学。Imaging Core人员协助用户操作仪器并分析 成像数据。该核心为生物医学研究卓越中心的现任PI提供建议 （COBRE）应用程序使用成像核心进行特定研究。图像核心提供了 对COBRE支持的第一阶段的项目提供了巨大的帮助，并将继续随时提供服务 所有COBRE实验室都可以方便地获得这些数据，以生成高质量的数据。朝向 提供高效率和高质量的成像服务以及建立强大的成像基础设施的目标 在CCM中，我们为Core增加了新的功能和新的成像系统。我们的具体目标是：1） 为COBRE调查人员提供项目特定的培训和咨询; 2）开发和适应 艺术成像技术，以加强早期和试点项目研究人员的研究;以及3） 开发和实施新的方法，以加强CCM成像服务，并使这些服务可用于 COBRE和非COBRE用户。这一核心将提供一个方便的设施，调查人员可以 使用各种类型的成像系统评估他们的组织和/或细胞样品。贾建航博士， 成像核心主任，是一个高生产力的研究人员谁已经成功地获得了大量的 校外研究支持，包括NIGMS最大化研究者研究奖（MIRA）（R35） 该奖项授予广泛依赖复杂成像能力的知名调查人员。曾就职 与所有毕业的COBRE PI密切合作，为他们成功获得 独立研究支持。贾博士指导了四个CCM研究项目的发展， 第二阶段的应用，他将继续建议CCM研究人员的实验设计，使用 成像方式。