Epigenomic and Genomic Factors emerging from Poor Social Determinants of Health and their impact on Breast Cancer associated with Obesity and Comorbidities in African American and Latino Women

不良健康社会决定因素中出现的表观基因组和基因组因素及其对与非裔美国人和拉丁裔女性肥胖和合并症相关的乳腺癌的影响

• 批准号: 10581687
• 负责人: Jaydutt V. Vadgama
• 金额: $ 39.15万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581687
• 关键词: Acceleration; African American; African American population; Age; Area; Biological Markers; Biological Phenomena; Blood specimen; Breast Cancer Risk Factor; Cancer cell line; Cardiovascular Diseases; Chronic; Clinical; Communicable Diseases; Communities; County; DNA Methylation; DNA Sequence Alteration; Data; Diabetes Mellitus; Diagnosis; Disease; Disparity; Environmental Risk Factor; Epigenetic Process; Ethnic Origin; Exposure to; Genes; Genetic; Genomics; Gonadal Steroid Hormones; Growth; Growth Factor; Healthcare; Hispanic; Household; Hypertension; Incidence; Incidence Study; Income; Individual; Inflammatory; Intervention; Invaded; Latina; Latina Population; Latino; Latino Population; Length; Life Style; Literature; Location; Los Angeles; Malignant - descriptor; Malignant Neoplasms; Medicine; Mental Health; Molecular; Morbidity - disease rate; Mutation; Neoplasm Metastasis; Non-Insulin-Dependent Diabetes Mellitus; Normal Cell; Obesity; Outcome; Outcome Study; Participant; Pathway interactions; Physical environment; Population; Postmenopause; Poverty; Precipitating Factors; Premenopause; RNA methylation; Race; Reduce health disparities; Research; Resources; Risk; Role; Science; Services; Social Environment; Socioeconomic Factors; Specimen; Technology; Time; Tissue Sample; Translational Research; Tumor Angiogenesis; Tumor Promotion; Tumor Suppressor Genes; Universities; Woman; breast cancer progression; cancer health disparity; cancer risk; cancer stem cell; cancer type; chemokine; cohort; comorbidity; cytokine; demographics; environmental stressor; epigenomics; federal poverty level; health care availability; health disparity; health inequalities; histone modification; hormone receptor-positive; malignant breast neoplasm; methylation pattern; mortality; next generation sequencing; poor health outcome; precision medicine; public health relevance; response; social; social disparities; social health determinants; social stressor; socioeconomics; stem cell population; telomere; tumor progression

Abstract: The Purpose of this study is to determine how social and epigenomic factors that are associated with social determinants of health cause increase in Obesity and Comorbidities, resulting in increased risk for breast cancer. Specifically, this study will examine cancer health disparities associated with obesity and other comorbidities in African American and Latina populations residing South Los Angeles. Multiple reasons have been presented in the literature suggesting both socioeconomic and biological phenomena which may contribute to these disparities. Charles R. Drew University of Medicine and Science (CDU) serves the most underserved and under- resourced populations located in the Service Planning Area 6 (SPA6) region of South Los Angeles. Our communities comprise primarily of African Americans (27%) and Latinos (68%). From the residents in SPA6, 31% of the population lives in poverty (household income < 100% federal poverty level (FPL)) and median household income is $36,400, while Los Angeles county is at 17% FPL and with median household income of $56,241. Healthcare and physical environment resources are significantly poor compared to west Los Angeles (SPA5). The Hypothesis and Rationale of this proposed study are: Underserved and Under-resourced communities with poor social determinants of health, are more likely to develop health disparities such as Obesity, Diabetes (T2D), and Hypertension (HTN). These individuals are at increased risk for developing several types of cancers. We will study the incidence and progression of Breast Cancer in these individuals. We will employ biomarkers such as: Sex Hormones, Growth Factors, Inflammatory Cytokines, DNA Methylation, RNA Methylation, and Histone Modifications as they relate to Epigenomic and Genomic changes and their association with risk and clinical outcomes. To accomplish the objectives of our proposal, we will employ the following specific research aims:

摘要： 本研究的目的是确定社会和表观基因组因素是如何与社会 健康决定因素导致肥胖和合并症增加，导致乳腺癌风险增加。 具体来说，这项研究将检查与肥胖和其他合并症相关的癌症健康差异， 居住在南洛杉矶的非洲裔美国人和拉丁裔人口。多个原因已提出， 文献表明，社会经济和生物现象可能有助于这些 差距。Charles R.医学和科学的德鲁大学（CDU）服务最不足，根据- 位于南洛杉矶服务规划区6（SPA 6）区域的资源丰富的人口。我们 社区主要由非裔美国人（27%）和拉丁美洲人（68%）组成。从SPA 6的居民那里， 31%的人口生活在贫困中（家庭收入< 100%联邦贫困线）， 家庭收入为36，400美元，而洛杉矶县的FPL为17%，家庭收入中位数为 五万六千二百四十一美元与西洛杉矶相比，医疗保健和物理环境资源明显较差 （SPA5）。 这项拟议研究的假设和基本原理是：服务不足和资源不足的社区 健康的社会决定因素较差，更有可能发展健康差异，如肥胖，糖尿病 (T2D)高血压（HTN）。这些人患几种癌症的风险增加。 我们将研究这些个体中乳腺癌的发病率和进展。我们将使用生物标记 例如：性激素、生长因子、炎性细胞因子、DNA甲基化、RNA甲基化，以及 组蛋白修饰，因为它们涉及表观基因组和基因组变化及其与风险和 临床结果。为了实现我们建议的目标，我们将进行以下具体研究 目的：