The Kansas Institute for Precision Medicine

堪萨斯精准医学研究所

• 批准号: 10582647
• 负责人: ANDREW K. GODWIN
• 金额: $ 224.19万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2024-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10582647
• 关键词: Address; Advisory Committees; Applied Research; Area; Basic Science; Biomedical Engineering; Biomedical Research; Cancer Center; Caring; Centers of Research Excellence; Characteristics; Clinic; Clinical; Collaborations; Communities; Department chair; Development; Diagnosis; Diagnostic; Diet; Discipline; Disease; Education; Environment; Evolution; Faculty; Family; Fostering; Funding; Generations; Goals; Healthcare; Individual; Infrastructure; Institution; Internal Medicine; Kansas; Knowledge; Laboratories; Leadership; Life Style; Medical; Medical History; Medical center; Medicine; Mentors; Methods; Mission; Molecular; Molecular Medicine; Molecular Profiling; Outcome; Participant; Pathology; Patient Care; Patient-Focused Outcomes; Patients; Peer Review; Persons; Physicians; Precision therapeutics; Process; Program Sustainability; Public Health; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resource Sharing; Rural; Science; Scientist; Seasons; Secure; Shapes; Training; Training Programs; Translating; Translational Research; Universities; base; biobank; biomarker development; biomarker validation; clinical care; clinical practice; disparity gap; experience; human disease; implementation barriers; improved; individualized medicine; innovation; insight; invention; medical schools; meetings; molecular marker; next generation; novel diagnostics; organizational structure; personalized diagnostics; population health; precision medicine; programs; recruit; standard of care; tool; translational physician; translational scientist

ABSTRACT The overall objective of the “Kansas Institute for Precision Medicine” (KIPM) COBRE at the University of Kansas Medical Center (KUMC) is to advance the customization of healthcare through promoting innovative scientific discoveries. The KIPM COBRE will provide support to advance the mission of KUMC through innovative mentoring and training programs with a precision medicine theme. The KIPM COBRE will also strengthen the biomedical research capacity within our region by enhancing the research base and infrastructure/core capacities. To accomplish this, the KIPM COBRE proposes the following Specific Aims: Specific Aim 1. Recruit and mentor a group of outstanding junior investigators in diverse disciplines with different disease focus areas that have a common theme directed toward precision medicine. In a rigorous pre-selection process, five promising junior investigators (and two alternative investigators) were selected from nearly 20 applicants, all of which had a research theme directly related to precision medicine. Decisions were based on the content of research proposals and training potential that were evaluated by our leadership team (including the three PIs of the proposed COBRE, the senior leadership at KUMC including the Dean, department chairs, and past PIs of COBREs within KUMC). Each applicant has been assigned at least one internal and one external mentor with expertise related to their area of study. All COBRE faculty candidates contributed to discussions regarding infrastructure necessary to enhance their projects via one-on-one meetings with the PIs and research core directors were formed based in infrastructure needs to enhance their research capacity. Specific Aim 2. To develop the scientific, technical, mentoring and collaborative infrastructure for a cohesive and sustainable program in precision medicine. Relying on additional expertise afforded by our Internal Advisory Committee (IAC), the External Advisory Committee (EAC), and an interactive mentoring program, we will continue to guide and mentor the next generation of translational scientists to advance molecular medicine in the 21st century with a thematic focus on precision medicine. Four shared resources, i.e., Administrative, Biomedical Engineering (BME), Biobanking and Biomarker Validation (BBV), and Quantitative `Omics' (QO) Cores, will be developed to assist the projects and serve the extended research community in Kansas and beyond. Specific Aim 3. To foster and enhance collaborations between basic scientists and clinicians and facilitate translational research directed toward the development of biomarkers, new diagnostics and/or treatments for human disease. Pilot research projects funded by the School of Medicine, the Departments of Internal Medicine and Pathology and Laboratory Medicine, and the NCI-designated KU Cancer Center, will provide opportunities to identify both senior and junior investigators within our institute to expand the breadth and depth of research in the fields of precision medicine.

摘要 堪萨斯大学“堪萨斯精准医学研究所”（KIPM）COBRE的总体目标 医疗中心（KUMC）是通过促进创新的科学， 发现。KIPM COBRE将提供支持，通过创新的方式推进KUMC的使命。 以精准医疗为主题的指导和培训计划。KIPM COBRE还将加强 通过加强研究基础和基础设施/核心，提高本地区的生物医学研究能力 能力。为了实现这一目标，KIPM COBRE提出了以下具体目标：具体目标1。招募 并指导一批杰出的初级研究人员在不同的学科与不同的疾病重点领域 有一个共同的主题指向精准医疗。在严格的预选过程中，五个 从近20名申请人中选出了有前途的初级调查员（和两名备选调查员）， 其研究主题与精准医疗直接相关。决定是根据 我们的领导团队（包括以下三位PI）评估的研究建议和培训潜力 拟议的COBRE，KUMC的高级领导层，包括院长，系主任和过去的PI， KUMC内部的COBREs）。每个申请人都被分配了至少一名内部和一名外部导师， 与他们的研究领域相关的专业知识。所有COBRE教师候选人都参与了关于 通过与PI和研究核心的一对一会议， 根据基础设施的需要组建了主任，以提高他们的研究能力。具体目标2。到 发展科学、技术、指导和协作基础设施， 精准医疗的计划依靠我们内部咨询委员会提供的额外专业知识 (IAC)，外部咨询委员会（EAC）和互动指导计划，我们将继续指导 并指导下一代转化科学家在21世纪推进分子医学， 精准医疗的主题重点。四个共享资源，即，行政、生物医学工程 (BME)生物库和生物标志物验证（BBV）以及定量“组学”（QO）核心，将被开发， 协助项目并为堪萨斯及其他地区的扩展研究社区提供服务。具体目标3。到 促进和加强基础科学家和临床医生之间的合作，并促进转化研究 本发明的目的在于开发用于人类疾病的生物标志物、新的诊断和/或治疗。试点 由医学院、内科及病理学系资助的研究项目， 实验室医学和NCI指定的KU癌症中心，将提供机会，以确定两个高级 和初级研究人员在我们的研究所，以扩大在精密领域的研究广度和深度 药