Biospecimen Shared Resource

Biosecimen共享资源-项目摘要 生物共用资源(BSR)，由安德鲁·K·戈德温博士领导(主任，BSR；副主任， KUCC和D3ET成员)和由Rashna Madan，MBBS，FCAP，FASCP(BSR助理主任)扮演 在堪萨斯大学癌症中心(KUCC)的伦理收集、存储、注释和 高质量生物标本的分布，如新鲜/新鲜冷冻的不同组织学和 体液(血液、唾液、尿液、腹水)，这是支持翻译研究和 由研究人员发起的研究。BSR还提供专家组织病理学支持，并结合专业知识 病理学家、翻译研究人员和技术人员共同制作了一份全面而有重点的 支持KUCC的研究活动的方法。BSR由内部顾问委员会(IAB)监督 导演和助理导演分别是戈德温和马丹。Colleen Reilly(项目经理) 提供日常工作人员监督和卡桑德拉·希普曼(项目开发经理) 对参与者同意的监督。BSR由四名研究协调员组成，他们确定参与者的身份 和管理知情同意，一名临床实验室主管，两名实验室技术人员 生物标本的加工和储存，一名执行高级组织学服务的组织技术专家， 包括为治疗性临床试验提供组织学支持，以及一名癌症登记员执行搜索 样本以满足用户要求，并将无法以电子方式提供的临床信息输入到我们的开发中 癌症临床结果数据库(C3OD)。此外，还促进了组织生物样品的收集 由病理助理、住院医生和KU医院和印地安溪校区的研究员作为 Ku Health System对癌症中心BSR的承诺。BSR为生物质学提供了完整的装备 收集、处理和分发，因此，BSR遵守OSHA实验室标准 处理冷冻剂，ISBER存储库最佳实践，以及NCI生物检疫资源最佳实践， 并制定了标准操作程序来管理这些过程中的每一个。收藏品， BSR工作人员对样品的处理和分发在过去四年中有了很大的增长 (2012-2015)，现在包括来自国际刑事法院的儿童肉瘤集合和来自 杜鲁门医学中心的卫星生物质谱库，中西部癌症联盟和 堪萨斯城安全网医疗系统。这个基本的KUCC共享资源总共容纳了9000多人 组织和20,000多份血样(包括个人的单次或重复抽血 被诊断为癌症、良性疾病或没有癌症证据)，来自17,000名参与者(由 2015年底)，自2012年以来分发了近16,000份标本等分。在2015财年(报告年)， 74名调查人员使用了BSR服务，其中44人是KUCC成员，在此期间增加了近2倍 资助期。

Biospecimen Shared Resource – Project Summary The Biospecimen Shared Resource (BSR), led by Andrew K. Godwin, PhD (Director, BSR; Deputy Director, KUCC, and D3ET member) and by Rashna Madan, MBBS, FCAP, FASCP (Assistant Director, BSR) plays a vital role in the University of Kansas Cancer Center (KUCC) by its ethical collection, storage, annotation, and distribution of high quality biospecimens, such as fresh/fresh-frozen tumor tissues of varying histology and bodily fluids (blood, saliva, urine, ascites fluids) which are essential to support translational research and investigator-initiated studies. The BSR also provides expert histopathology support and combines the expertise of pathologists, translational researchers, and technical personnel to produce a comprehensive and focused approach to support the research activities at KUCC. The BSR is overseen by an internal advisory board (IAB) and the director and assistant director, Godwin and Madan, respectively. Colleen Reilly (Project Manager) provides the day-to-day staff supervision and Cassaundra Shipman (Program Development Manager) oversight of participant consenting. The BSR is staffed by four research coordinators who identify participants and administer informed consent, one clinical laboratory supervisor, two lab technicians who handle the processing and banking of biospecimens, one histotechnologist who performs advanced histology services, including histology support for therapeutic clinical trials, and one cancer registrar who performs searches for samples to match user requests and enters clinical information not available electronically into our developing Curated Cancer Clinical Outcomes Database (C3OD). Additionally tissue biospecimen collection is facilitated by pathology assistants, residents and fellows at the KU Hospital and the Indian Creek Campus as part of the KU Health System's commitment to the Cancer Center's BSR. The BSR is fully equipped for biospecimen collection, processing, and distribution, and thus, the BSR adheres to the OSHA laboratory standards for handling cryogens, ISBER Best Practice for Repositories, and NCI Best Practices for Biospecimen Resources, and has developed Standard Operating Procedures to govern each of these processes. The collection, processing, and distribution of samples by the BSR staff has grown substantially over the past four years (2012-2015) and now includes collections of pediatric sarcomas from ICC and underserved populations from the satellite biospecimen bank at Truman Medical Center, a member of the Midwest Cancer Alliance and the Kansas City safety-net health system. Together, this essential KUCC shared resource, houses over 9,000 tissues and more than 20,000 blood samples (including either single or repeat draws from individuals diagnosed with cancer, benign disease, or no evidence of cancer) from >17,000 participants (enrolled by the end of 2015) and distributed nearly 16,000 specimen aliquots since 2012. In CY15 (the reporting year), the BSR services were used by 74 investigators, 44 who were KUCC members, an increase of nearly 2-fold during the funding period.