Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)
跨学科 NexGen 结核病研究推进中心 (IN-TRAC)
基本信息
- 批准号:10588203
- 负责人:
- 金额:$ 115.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-10 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AddressAnimal ModelAnimalsBiomedical ResearchChestCitiesClinicClinicalClinical ManagementClinical ResearchClinical ServicesCommunicable DiseasesCommunicationCommunitiesComplementComprehensionConfocal MicroscopyCountryCytometryDevelopmentDisciplineEducational CurriculumFundingFunding AgencyGrantHealthHealth ProfessionalHospitalsIACUCImageIndividualIndustryInpatientsInterdisciplinary StudyInternshipsKnowledgeLeadershipLearningMechanicsMexicoMissionMusNational Institute of Allergy and Infectious DiseaseOutpatientsPET/CT scanParticipantPatient CarePreventionProceduresProtocols documentationResearchResearch InstituteResearch PersonnelResourcesRisk AssessmentRodentScienceScientistSiteTexasTrainingTraining ProgramsTuberculosisUnited States National Institutes of HealthUniversitiesWorkWritingbiocontainment facilitycareer developmentcellular imagingcohortcommercializationexperienceexternshiplive cell imagingmetropolitanmultidisciplinarynext generationnonhuman primateorganizational structurepeerpoint of carepreventprogramsprospectivesingle-cell RNA sequencingskillssuccesstoolwhole body imaging
项目摘要
TEXAS BIOMED IN-TRAC OVERALL ABSTRACT
The Interdisciplinary NexGen TB Research Advancement Center (IN-TRAC) at Texas Biomedical Research
Institute (Texas Biomed) will attract the next generation of diverse researchers to the tuberculosis (TB) research
field, and develop them into independent researchers with multi-disciplinary skills and real-world experience of
clinical TB. The product of IN-TRAC will be researchers that choose to work on some of the most challenging
and relevant translational problems in TB, and that work across academic disciplines and within a framework of
highly collaborative research. This will be achieved through 6 interrelated Cores. Administrative Core: The
central hub of IN-TRAC management and oversight, with responsibility for administrative and scientific
leadership; coordinating communication between Cores, researchers and NIH/NIAID Program staff and
providing an organizational structure to optimize multidisciplinary collaborations and interactions between the
Cores and among a diverse cohort of IN-TRAC participants. Development Core: Oversight of all career
development programming and courses, tailoring the research and clinical experiences, both intern and
externships, to each individual IN-TRAC participant, and management of the IN-TRAC pilot grant program.
Biosafety & Biocontainment Core: Extending the required biosafety training to a personalized curriculum
including theoretical and hands-on biocontainment training, understanding the mechanical and regulatory
requirements of a BSL3/ABSL3, coaching on how to develop biosafety protocols, and working through risk
assessments from the perspective of a Biosafety Officer. Research Imaging Core: Providing theoretical and
hands-on training from single cell imaging (confocal microscopy, cytometry, live cell imaging, single cell RNAseq)
through to whole body imaging in mice (IVIS) and Non-human primates (NHP) (PET/CT) within large, fully
outfitted BSL3/ABSL3 facilities. Animal Model Core: Implementing a training program to introduce all IN-TRAC
participants to the regulatory requirements for working with rodents and NHPs, how to develop a robust
experimental protocol, how to write an IACUC protocol, and hands-on animal handling and experimental
procedures. Clinical Research & Patient Care Core: Introducing IN-TRAC participants to TB patient care at
the only free-standing TB hospital in the US (Texas Center of Infectious Diseases) that manages some of the
most challenging cases of TB nationally. Partnering with this will be a clinical research experience at the US-
Mexico border, to experience TB studies in under-served and under-resourced communities.
德克萨斯州BioMed In-TRAC总体摘要
德克萨斯州生物医学研究中心跨学科NexGen结核病研究促进中心(IN-TRAC)
德克萨斯生物医学研究所将吸引下一代多样化的研究人员参与结核病(TB)的研究
领域,并将他们培养成具有多学科技能和现实世界经验的独立研究人员
临床结核病。IN-TRAC的产品将是选择在一些最具挑战性的领域工作的研究人员
和相关的结核病翻译问题,并在跨学科和框架内工作
高度协作的研究。这将通过6个相互关联的核心来实现。管理核心:
TRAC内管理和监督的中央中心,负责行政和科学
领导力;协调核心、研究人员和NIH/NIAID计划工作人员之间的沟通
提供一个组织结构,以优化多学科协作和
在核心和不同的“核心预算资源调拨目标”参与者之间开展了一项研究。发展核心:监督所有职业
发展规划和课程,量身定制研究和临床经验,包括实习生和
向每一名内部TRAC项目参与者发放外部奖学金,以及管理内部TRAC项目试点赠款计划。
生物安全和生物遏制核心:将所需的生物安全培训扩展到个性化课程
包括理论和实际操作的生物遏制培训,了解机械和监管
BSL3/ABSL3的要求,如何开发生物安全协议的指导,以及如何应对风险
从生物安全官员的角度进行评估。研究成像核心:提供理论和
单细胞成像实践培训(共焦显微镜、细胞术、活细胞成像、单细胞RNAseq)
通过在小鼠(IVIS)和非人灵长类动物(NHP)(PET/CT)中进行全身成像
配备BSL3/ABSL3设施。动物模型核心:实施培训计划以引入All-TRAC
参与者要按照监管要求处理啮齿动物和NHP,如何制定一个健壮的
实验协议,如何编写IACUC协议,以及动手操作动物和实验
程序。临床研究和患者护理核心:向TRAC参与者介绍结核病患者护理
美国唯一一家独立的结核病医院(德克萨斯传染病中心),管理着一些
全国最具挑战性的结核病病例。与此合作将是美国的一次临床研究体验-
墨西哥边境,在服务不足和资源不足的社区体验结核病研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Larry S. Schlesinger其他文献
Mycobacterium tuberculosis remodels host transcriptome
结核分枝杆菌重塑宿主转录组
- DOI:
10.1038/s41564-021-01056-x - 发表时间:
2022-01-31 - 期刊:
- 影响因子:19.400
- 作者:
Melanie A. Carless;Larry S. Schlesinger - 通讯作者:
Larry S. Schlesinger
Identifying Mycobacterium tuberculosis virulence determinants - new technologies for a difficult problem.
识别结核分枝杆菌毒力决定因素——解决难题的新技术。
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:15.9
- 作者:
Lucy E. Desjardin;Larry S. Schlesinger - 通讯作者:
Larry S. Schlesinger
Antibody-independent classical complement pathway activation by wildtype and LPS O-antigen mutant <em>Francisella tularensis</em> strains
- DOI:
10.1016/j.molimm.2010.05.146 - 发表时间:
2010-08-01 - 期刊:
- 影响因子:
- 作者:
Corey D. Clay;John S. Gunn;Larry S. Schlesinger - 通讯作者:
Larry S. Schlesinger
Timing matters in macrophage/CD4+ T cell interactions: an agent-based model comparing emMycobacterium tuberculosis/em host-pathogen interactions between latently infected and naïve individuals
时机在巨噬细胞/CD4+T 细胞相互作用中很重要:一个基于代理的模型比较了潜伏感染和未感染个体之间的结核分枝杆菌宿主-病原体相互作用
- DOI:
10.1128/msystems.01290-24 - 发表时间:
2025-02-27 - 期刊:
- 影响因子:4.600
- 作者:
Alexis Hoerter;Alexa Petrucciani;Jordan Bonifacio;Eusondia Arnett;Larry S. Schlesinger;Elsje Pienaar - 通讯作者:
Elsje Pienaar
Impact of the elderly lung mucosa on emMycobacterium tuberculosis/em transcriptional adaptation during infection of alveolar epithelial cells
老年肺黏膜对肺泡上皮细胞感染期间结核分枝杆菌转录适应性的影响
- DOI:
10.1128/spectrum.01790-24 - 发表时间:
2024-10-30 - 期刊:
- 影响因子:3.800
- 作者:
Angélica M. Olmo-Fontánez;Anna Allué-Guardia;Andreu Garcia-Vilanova;Jeremy Glenn;Shu-Hua Wang;Robert E. Merritt;Larry S. Schlesinger;Joanne Turner;Yufeng Wang;Jordi B. Torrelles - 通讯作者:
Jordi B. Torrelles
Larry S. Schlesinger的其他文献
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{{ truncateString('Larry S. Schlesinger', 18)}}的其他基金
Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)
跨学科 NexGen 结核病研究推进中心 (IN-TRAC)
- 批准号:
10431465 - 财政年份:2022
- 资助金额:
$ 115.01万 - 项目类别:
Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection
健康和结核分枝杆菌感染期间的巨噬细胞核受体、代谢和免疫效应器
- 批准号:
10450960 - 财政年份:2020
- 资助金额:
$ 115.01万 - 项目类别:
Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection
健康和结核分枝杆菌感染期间的巨噬细胞核受体、代谢和免疫效应器
- 批准号:
10457308 - 财政年份:2019
- 资助金额:
$ 115.01万 - 项目类别:
Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection- Diversity Supplement
健康和结核分枝杆菌感染期间的巨噬细胞核受体、代谢和免疫效应器 - Diversity Supplement
- 批准号:
10116937 - 财政年份:2019
- 资助金额:
$ 115.01万 - 项目类别:
Expansion of Marmoset Breeding Facilities to Meet Increasing Research Demands
扩建狨猴饲养设施以满足不断增长的研究需求
- 批准号:
9933536 - 财政年份:2019
- 资助金额:
$ 115.01万 - 项目类别:
Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection
健康和结核分枝杆菌感染期间的巨噬细胞核受体、代谢和免疫效应器
- 批准号:
10215474 - 财政年份:2019
- 资助金额:
$ 115.01万 - 项目类别:
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