Expansion of Marmoset Breeding Facilities to Meet Increasing Research Demands

扩建狨猴饲养设施以满足不断增长的研究需求

• 批准号: 9933536
• 负责人: Larry S. Schlesinger
• 金额: $ 50万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-23 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9933536
• 关键词: Aging; Animal Housing; Animals; Area; Biomedical Research; Breeding; Callithrix; Callithrix jacchus jacchus; Communicable Diseases; Communities; Custom; Fertility; Funding; Health; Housing; Human; Human Resources; Infrastructure; Modeling; Monkeys; Neurosciences; Population; Positioning Attribute; Primates; Prize; Production; Research; Resources; Sales; Shunt Device; Training; Transgenic Organisms; Weaning; Zika Virus; aging gene; design; flexibility; improved; vaccine evaluation

The common marmoset (Callithrix jacchus) is becoming an increasingly important biomedical research model in neuroscience, aging and infectious disease. Due to its small size, fast maturation, and high fertility, this species is particularly prized for research into aging, gene editing and transgenic production. There is clear evidence of unmet demand for marmosets by the US research community, pointing to the value of increasing marmoset production. The Southwest National Primate Research Center (SNPRC) has the trained personnel and infrastructure in place to effectively and efficiently breed additional marmosets. Of particular importance, we have the largest population of marmosets in the US and can, therefore, most rapidly expand the breeding population without encountering the issue of having to search elsewhere for additional animals to put into breeding. However SNPRC is limited in the extent to which we can expand production by appropriate housing space, caging and support to shunt animals away from sales and research and into breeding. We therefore are requesting support for: (1) Housing Space. While the center has more than adequate land for expansion, we do require additional, appropriate indoor housing in order to expand production. The most expedient way to increase production capacity is the placement of a custom-designed modular building in association with our other marmoset housing. The proposed modular building would provide approximately 1,008 sq ft of additional animal housing space, increasing our housing space for production by approximately 75%. (2) Caging. Our rationale for the marmoset caging request is to both increase our capacity to house this species but, perhaps more importantly, to provide us with flexible caging options that can be used for pair-housing, small group housing or large group housing. We project that the support provided by this supplement would allow us within 2.5 years to support 64 breeding units as opposed to the 36 we presently support, increasing our weaned production per year from 90-110 animals to 160-192 animals - an approximately 75% increase. This will position SNPRC to rapidly increase production, if mechanisms of support for moving marmosets from sales or research into breeding become available in the coming year.

普通的摩尔果（Callithrix jacchus）正在成为越来越重要的生物医学研究模型 在神经科学，衰老和传染病中。由于其尺寸很小，快速成熟和高生育能力，因此 物种特别是研究衰老，基因编辑和转基因产生的物种。有清晰的 美国研究界对摩尔马人需求未满足的证据，指出了增加的价值 果酱生产。西南国家灵长类动物研究中心（SNPRC）拥有训练有素的人员 以及基础设施有效，有效地繁殖额外的摩尔果。特别重要的是 我们在美国拥有最多的摩尔马人，因此，最迅速地扩大了繁殖 人口没有遇到必须在其他地方寻找其他动物的问题 选育。但是，SNPRC在我们可以通过适当的住房扩展生产的程度上受到限制 空间，笼子和支撑分流动物远离销售和研究，再到繁殖。因此，我们 要求支持：（1）住房空间。尽管该中心有足够的土地来扩展，但 我们确实需要额外的，适当的室内住房来扩大生产。最方便的方式 提高生产能力是与我们的定制设计的模块化建筑的位置 其他摩尔果住房。拟议的模块化建筑将提供大约1,008平方英尺的额外 动物住房空间，将我们的住房生产空间增加了约75％。 （2）笼子。我们的 马尔莫斯特笼式请求的基本原理是提高我们容纳该物种的能力，但也许 更重要的是，为我们提供可用于配对的小组的柔性笼子 住房或大型住房。我们预测，该补充剂提供的支持将使我们在 2。5年来支持64个繁殖单元，而不是我们目前支持的36个，增加了断奶 每年从90-110只动物到160-192动物的产量 - 增长了约75％。这会 如果支持向销售中移动棉花糖的机制或 育种的研究将于来年提供。