Expansion of Marmoset Breeding Facilities to Meet Increasing Research Demands

普通绒猴（Callithrix jacchus）正成为一种日益重要的生物医学研究模型 在神经科学、衰老和传染病方面。由于其体积小，成熟快，繁殖力高， 物种在衰老、基因编辑和转基因生产方面的研究特别珍贵。有明确 美国研究界对绒猴需求未得到满足的证据，指出增加 绒猴生产。西南国家灵长类动物研究中心（SNPRC）拥有训练有素的人员， 和基础设施，以有效和高效地繁殖额外的绒猴。尤其重要的是， 我们拥有美国最大的绒猴种群，因此可以最迅速地扩大繁殖， 人口，而不会遇到必须在其他地方寻找额外的动物放入的问题 育种然而，SNPRC通过适当的住房来扩大生产的程度有限 空间，笼子和支持，以分流动物从销售和研究，并进入育种。因此我们 需要支持：（1）住房。虽然该中心有足够的土地进行扩张， 我们确实需要增加适当的室内住房，以扩大生产。最方便的方法 为了提高生产能力，我们将一个定制设计的模块化建筑与我们的 其他绒猴的住房。拟议的模块化建筑将提供约1，008平方英尺的额外空间， 动物饲养空间，使我们的生产用饲养空间增加了约75%。(2)牢笼我们 绒猴关进笼子的理由是为了增加我们容纳这个物种的能力，但是，也许 更重要的是，为我们提供了灵活的笼舍选择，可用于对住房，小团体， 住房或大集体住房。我们预计，这一补充提供的支持将使我们能够在 2.5年来支持64个育种单位，而不是我们目前支持的36个， 年生产量从90-110头增加到160-192头--大约增加了75%。这将 定位SNPRC迅速增加产量，如果支持机制从销售或 明年可以进行育种研究。

The common marmoset (Callithrix jacchus) is becoming an increasingly important biomedical research model in neuroscience, aging and infectious disease. Due to its small size, fast maturation, and high fertility, this species is particularly prized for research into aging, gene editing and transgenic production. There is clear evidence of unmet demand for marmosets by the US research community, pointing to the value of increasing marmoset production. The Southwest National Primate Research Center (SNPRC) has the trained personnel and infrastructure in place to effectively and efficiently breed additional marmosets. Of particular importance, we have the largest population of marmosets in the US and can, therefore, most rapidly expand the breeding population without encountering the issue of having to search elsewhere for additional animals to put into breeding. However SNPRC is limited in the extent to which we can expand production by appropriate housing space, caging and support to shunt animals away from sales and research and into breeding. We therefore are requesting support for: (1) Housing Space. While the center has more than adequate land for expansion, we do require additional, appropriate indoor housing in order to expand production. The most expedient way to increase production capacity is the placement of a custom-designed modular building in association with our other marmoset housing. The proposed modular building would provide approximately 1,008 sq ft of additional animal housing space, increasing our housing space for production by approximately 75%. (2) Caging. Our rationale for the marmoset caging request is to both increase our capacity to house this species but, perhaps more importantly, to provide us with flexible caging options that can be used for pair-housing, small group housing or large group housing. We project that the support provided by this supplement would allow us within 2.5 years to support 64 breeding units as opposed to the 36 we presently support, increasing our weaned production per year from 90-110 animals to 160-192 animals - an approximately 75% increase. This will position SNPRC to rapidly increase production, if mechanisms of support for moving marmosets from sales or research into breeding become available in the coming year.