Expansion of Marmoset Breeding Facilities to Meet Increasing Research Demands

扩建狨猴饲养设施以满足不断增长的研究需求

• 批准号: 9933536
• 负责人: Larry S. Schlesinger
• 金额: $ 50万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-23 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9933536
• 关键词: Aging; Animal Housing; Animals; Area; Biomedical Research; Breeding; Callithrix; Callithrix jacchus jacchus; Communicable Diseases; Communities; Custom; Fertility; Funding; Health; Housing; Human; Human Resources; Infrastructure; Modeling; Monkeys; Neurosciences; Population; Positioning Attribute; Primates; Prize; Production; Research; Resources; Sales; Shunt Device; Training; Transgenic Organisms; Weaning; Zika Virus; aging gene; design; flexibility; improved; vaccine evaluation

The common marmoset (Callithrix jacchus) is becoming an increasingly important biomedical research model in neuroscience, aging and infectious disease. Due to its small size, fast maturation, and high fertility, this species is particularly prized for research into aging, gene editing and transgenic production. There is clear evidence of unmet demand for marmosets by the US research community, pointing to the value of increasing marmoset production. The Southwest National Primate Research Center (SNPRC) has the trained personnel and infrastructure in place to effectively and efficiently breed additional marmosets. Of particular importance, we have the largest population of marmosets in the US and can, therefore, most rapidly expand the breeding population without encountering the issue of having to search elsewhere for additional animals to put into breeding. However SNPRC is limited in the extent to which we can expand production by appropriate housing space, caging and support to shunt animals away from sales and research and into breeding. We therefore are requesting support for: (1) Housing Space. While the center has more than adequate land for expansion, we do require additional, appropriate indoor housing in order to expand production. The most expedient way to increase production capacity is the placement of a custom-designed modular building in association with our other marmoset housing. The proposed modular building would provide approximately 1,008 sq ft of additional animal housing space, increasing our housing space for production by approximately 75%. (2) Caging. Our rationale for the marmoset caging request is to both increase our capacity to house this species but, perhaps more importantly, to provide us with flexible caging options that can be used for pair-housing, small group housing or large group housing. We project that the support provided by this supplement would allow us within 2.5 years to support 64 breeding units as opposed to the 36 we presently support, increasing our weaned production per year from 90-110 animals to 160-192 animals - an approximately 75% increase. This will position SNPRC to rapidly increase production, if mechanisms of support for moving marmosets from sales or research into breeding become available in the coming year.

常见的绒猴(Callithrix Jacchus)正成为一种日益重要的生物医学研究模式 在神经科学、衰老和传染病方面。由于体型小，成熟快，繁殖力高，这 物种在衰老、基因编辑和转基因生产方面的研究尤为珍贵。有一点很清楚 美国研究界对绒猴需求未得到满足的证据，表明了增加 绒猴生产。西南国家灵长类研究中心(SNPRC)拥有训练有素的人员 和基础设施到位，以有效和高效地繁殖更多的绒猴。尤其重要的是， 我们拥有美国最多的绒猴种群，因此可以最快地扩大繁殖 无需遇到不得不在其他地方寻找更多动物放入的问题 繁衍后代。然而，SNPRC通过适当的住房来扩大生产的程度是有限的 空间、笼子和支持，将动物从销售和研究转移到繁殖。因此，我们 正在请求支持：(1)住房空间。虽然该中心有足够的土地进行扩建， 为了扩大生产，我们确实需要额外的、适当的室内住房。最便捷的方式 为了提高生产能力，我们将定制设计的模块化建筑与我们的 其他绒猴住房。拟议的模块化建筑将提供约1,008平方英尺的额外 动物住房空间，使我们用于生产的住房空间增加了约75%。(2)笼子。我们的 将绒猴关在笼子里的理由是为了增加我们容纳这种物种的能力，但也许 更重要的是，为我们提供了灵活的笼子选项，可用于配对住房、小团体 住房或大型团体住房。我们预计，本附录提供的支持将使我们能够在 两年半支持育种单位，而不是我们目前支持的36个，增加了我们的断奶 每年的产量从90-110只动物增加到160-192只--大约增加了75%。这将是 定位SNPRC以快速增加产量，如果支持将绒猴从销售中转移或 对育种的研究将在来年实现。