Human and Animal Imaging Core

人类和动物成像核心

• 批准号: 10237684
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 27.98万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-21 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10237684
• 关键词: Affect; Algorithms; Anatomy; Animal Model; Animals; Biochemical; Bioinformatics; Biological Markers; Brain; Brain Diseases; Brain Injuries; Brain imaging; Cells; Child; Clinical; Clinical Research; Cognitive; Collaborations; Computer software; Development; Discipline; Disease; Disease model; District of Columbia; Dyslexia; Education; Epilepsy; Evaluation; Faculty; Fostering; Functional Imaging; Genomics; Hospitals; Human; Human Resources; Image; Imaging Device; Imaging Techniques; Imaging technology; Inborn Errors of Metabolism; Individual; Infant; Infrastructure; Injury; Inpatients; Institution; Intellectual and Developmental Disabilities Research Centers; Intervention; Investments; Laboratories; Learning; Machine Learning; Magnetic Resonance Imaging; Measurement; Methods; Microscopy; Mission; Molecular; Molecular Structure; Monitor; Motion; Neonatal; Neuronal Plasticity; Outcome; Pathway Analysis; Performance; Play; Population; Positron-Emission Tomography; Protocols documentation; Quality Control; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sequence Analysis; Services; Site; Structure; Supervision; Targeted Research; Technical Expertise; Techniques; Technology; Time; Tissues; Training; Training Support; Universities; Work; analytical method; animal imaging; autism spectrum disorder; base; career; congenital heart disorder; cost; cost effective; data integrity; data standards; design; fetal; flexibility; human imaging; human model; hypoxic ischemic injury; imaging facilities; imaging modality; improved; in vivo; innovation; instrument; instrumentation; magnetic field; molecular imaging; neonate; neural circuit; neurobehavioral; neuroimaging; neuroprotection; novel; novel imaging technology; perinatal stroke; pre-clinical; preclinical study; relating to nervous system; response; single photon emission computed tomography; skills; spectroscopic imaging

Abstract The Human and Animal Imaging Core (HAIC) provides access to state-of-the-art in vivo whole brain imaging technologies to DC-IDDRC investigators in order to support, facilitate, and enhance IDD-targeted research in humans and in animal models. To achieve the Core’s aims we have established advanced imaging facilities at three collaborating DC-IDDRC institutions - Howard University (HU), Georgetown University (GU), and Children’s National Hospital (CNH) - that provide structural and functional imaging of animal models and human populations. The HAIC provides access to a wide array of imaging tools to investigate mechanisms of disease, establish biomarkers, examine effects of disease, and monitor outcomes of interventions. We have made significant institutional investments in 3T human MRI scanners at CNH, and GU that provide researchers with state-of-the-art imaging instrumentation and expand our imaging capacity in neonates and ill children. Furthermore, we have also invested in MRI scanner/software upgrades and added PET, SPECT, and CT to the preclinical animal imaging facilities at HU. HAIC personnel provide technical expertise in imaging strategy design, essential imaging services, acquisition and innovative imaging sequences and analysis methods across all sites and institutions. Core faculty and staff also help educate, train, and support investigators in the use of advanced neuroimaging methods, applications, and analysis software as well as foster innovation. The HAIC works synergistically, and fosters collaborations, with other DC-IDDRC cores including the Neurobehavioral Evaluation, the Cell and Tissue Microscopy Core, the Genomics and Bioinformatics Core, and Clinical Translational Cores, and supports the P50 Research Project. Our administrative structure provides the quality control necessary for the integrity of a smoothly functioning core to achieve the DC-IDDRC mission.

摘要 人类和动物成像核心(HAIC)提供最先进的活体全脑成像 向DC-IDDRC调查人员提供技术，以支持、促进和加强针对IDD的研究 在人类和动物模型中。为了实现核心的目标，我们在 三个合作的DC-IDDRC机构--霍华德大学(HU)、乔治敦大学(GU)和 国家儿童医院(CNH)-提供动物模型的结构和功能成像以及 人类人口。HAIC提供了一系列成像工具来研究 疾病，建立生物标记物，检查疾病的影响，监测干预措施的结果。我们有 在CNH和GU的3T人体MRI扫描仪上进行了重大的机构投资，为研究人员提供了 使用最先进的成像仪器，并扩大我们对新生儿和患病儿童的成像能力。 此外，我们还投资于MRI扫描仪/软件升级，并将PET、SPECT和CT添加到 HU的临床前动物成像设备。HAIC人员提供成像战略方面的技术专长 设计、基本成像服务、获取和创新成像序列和分析方法 覆盖所有站点和机构。核心教职员工还帮助教育、培训和支持 使用先进的神经成像方法、应用程序和分析软件，并促进创新。这个 HAIC协同工作，促进与其他DC-IDDRC核心的合作，包括 神经行为评估，细胞和组织显微镜核心，基因组学和生物信息学核心，以及 临床翻译核心，并支持P50研究项目。我们的管理结构提供了 顺利运作的核心的完整性所需的质量控制，以实现DC-IDDRC的任务。