District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC)

哥伦比亚特区智力与发育障碍研究中心 (DC-IDDRC)

• 批准号: 10686054
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 137.05万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-21 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10686054
• 关键词: Academic Medical Centers; Address; Animal Model; Animals; Area; Attenuated; Basic Science; Behavioral; Bioinformatics; Biological Markers; Brain; Brain imaging; Caring; Cells; Child; Clinical; Clinical Research; Cognitive; Collaborations; Communication; Communities; Companions; Core Facility; DNA analysis; DNA sequencing; Dedications; Development; Developmental Disabilities; Disease; District of Columbia; Doctor of Philosophy; Enhancement Technology; Environment; Evaluation; Family; Future; Genetic Diseases; Genomics; Goals; Grant; Growth; Home; Hospitals; Human; Image Analysis; Imaging Device; Imaging technology; Individual; Innovative Therapy; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; International; Intervention; Investigation; Laboratories; Lead; Learning; Link; Maps; Mental Health; Messenger RNA; Microscopy; Mission; Molecular; Neonatal Brain Injury; Neurobehavioral Manifestations; Neurodevelopmental Disorder; Neurosciences; Optics; Outcome Measure; Pathology; Pilot Projects; Play; Postdoctoral Fellow; Prevention approach; Prevention strategy; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Scientist; Statistical Data Interpretation; Strategic Planning; Structure; Sum; Technology; Testing; Therapeutic; Tissues; Training; Training and Education; Translating; Translational Research; Universities; Washington; Youth; animal imaging; behavioral phenotyping; bench to bedside; cellular imaging; clinical development; clinical outcome measures; clinical translation; community based participatory research; comorbidity; cost effective; design; effective therapy; fetal; flexibility; fundamental research; health disparity; human imaging; image processing; improved; in vivo; innovation; investigator training; molecular imaging; multidisciplinary; neurobehavioral; neurodevelopment; neuroimaging; novel; novel diagnostics; novel therapeutics; pre-clinical; prevent; programs; quality assurance; recruit; research data dissemination; response; success; supportive environment; synergism; tool; training opportunity; treatment strategy

The mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDDs), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Hospital (lead), George Washington University, Howard University, and Georgetown University). Our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDDs; 2) To provide accessible, state-of-the-art,cost- effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses two IDDR themes (Interventions and Management of Co-morbid Mental Health Conditions; Outcome Measures or Biomarkers for Interventions or Treatments). The DC-IDDRC Director, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation, as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one- stop-shop” for IDDR investigators, assisting at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Bioinformatics Core (GBC) provides advanced genomics technologies and specialized statistical analyses for DNA and mRNA studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular/molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo/ex vivo whole brain imaging, image processing, and image analysis for human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral research support to define developmental and behavioral phenotypes in humans and animals. Our project “Intervention-induced plasticity of flexibility and learning mechanisms in ASD” utilizes the CTC, HAIC and NEC. Through these components, the DC- IDDRC will enhance the recruitment and training of investigators, generate innovation, and promote transdisciplinary research to facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDDs.

DC-IDDRC的使命是扩大我们对智力和精神疾病根源的理解， 发展性残疾（IDDs），开发创新疗法，预防或减轻 我们的目标是消除这些障碍，使每个儿童都能充分发挥其身体和智力潜力。实现这一 我们的使命是提供一个丰富的环境，在四个协作的DC中执行完全翻译的IDDR 学术医疗中心（国立儿童医院（牵头）、乔治华盛顿大学、霍华德 乔治敦大学（Georgetown University）。我们的具体目标是：1）找出原因，开发新的 预防或改善IDD的临床方法; 2）提供易于获得、最先进、成本低廉的 建立有效的核心设施，以便在减灾十年方面进行协调一致的多学科研究和教育/培训; 为从事IDDR的研究人员提供知识之家;以及4）实施创新的研究项目 它涉及两个减灾十年主题（共病心理健康状况的干预和管理; 干预或治疗的结果测量或生物标志物）。DC-IDDRC主任Vittorio Gallo， 博士，是一位国际知名的神经科学家，他将指导行政核心， DC-IDDRC的组织纽带，提供管理、行政、沟通和培训， 确保合规和质量保证，指导战略规划和招聘，并促进 DC-IDDRC的增长。科学核心为调查提供了一个综合平台和协同作用， 这是真正翻译的IDDR所要求的。临床翻译核心（CTC）旨在作为“一个- 为IDDR研究者提供“一站式”服务，在临床和转化研究的各个阶段提供协助 优化基础研究的高效优质实施。基因组学和 生物信息学核心（GBC）提供先进的基因组学技术和专业的统计分析 用于DNA和mRNA研究。细胞和组织显微镜核心（CTMC）支持研究人员， 广泛的先进细胞/分子成像工具，用于最先进的神经科学研究。的 人类和动物成像核心（HAIC）为体内/体外整体成像提供科学和技术支持。 用于人类和动物研究的脑成像、图像处理和图像分析。神经行为 评估核心（NEC）提供先进的神经行为研究支持，以定义发展 以及人类和动物的行为表型。我们的项目“干预诱导的柔性可塑性 ASD中的学习机制”利用了CTC、HAIC和NEC。通过这些组件，DC- IDDRC将加强调查人员的招聘和培训，促进创新， 跨学科研究，以促进新的诊断，实施和传播 和治疗IDDs的进展。

项目成果

Neurodevelopment in Down syndrome: Concordance in humans and models.

唐氏综合症的神经发育：人类和模型中的一致性。

• DOI: 10.3389/fncel.2022.941855
• 发表时间: 2022
• 期刊: FRONTIERS IN CELLULAR NEUROSCIENCE
• 影响因子: 5.3
• 作者: Klein, Jenny A.;Haydar, Tarik F.
• 通讯作者: Haydar, Tarik F.

The cortical NG2-glia response to traumatic brain injury.

• DOI: 10.1002/glia.24342
• 发表时间: 2023-05
• 期刊: Glia
• 影响因子: 6.2

Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal.

胎儿功能连接组中与孕龄相关的变化：全球信号的子宫内证据。

• DOI: 10.1093/cercor/bhac209
• 发表时间: 2023
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Kim,Jung-Hoon;DeAsis-Cruz,Josepheen;Cook,KevinM;Limperopoulos,Catherine
• 通讯作者: Limperopoulos,Catherine

Understanding the Pathophysiology of Congenital Vestibular Disorders: Current Challenges and Future Directions.

• DOI: 10.3389/fneur.2021.708395
• 发表时间: 2021
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: Peusner KD;Bell NM;Hirsch JC;Beraneck M;Popratiloff A
• 通讯作者: Popratiloff A

Multidimensional analysis of behavior predicts genotype with high accuracy in a mouse model of Angelman syndrome.

• DOI: 10.1038/s41398-022-02206-3
• 发表时间: 2022-10-03
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Tanas, Joseph K.;Kerr, Devante D.;Wang, Li;Rai, Anika;Wallaard, Ilse;Elgersma, Ype;Sidorov, Michael S.
• 通讯作者: Sidorov, Michael S.