Language and cognition after perinatal stroke

围产期卒中后的语言和认知

• 批准号: 10527367
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 59.42万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10527367
• 关键词: Adult; Affect; Age; Area; Automobile Driving; Behavior Therapy; Biological; Birth; Brain; Brain Injuries; Cerebral Palsy; Child; Cognition; Cognitive; Comprehension; Data; Development; Emotions; Environmental Risk Factor; Exhibits; Face; Focal Brain Injuries; Foundations; Functional Magnetic Resonance Imaging; Future; Hemiplegia; Human; Impaired cognition; Impairment; Individual; Infrastructure; Injury; Language; Language Development; Language Tests; Left; Life; Linguistics; Literature; Longitudinal Studies; Maps; Methods; Middle Cerebral Artery Infarction; Modeling; Names; Neuropsychological Tests; Outcome; Patient Recruitments; Pattern; Performance; Perinatal; Perinatal Brain Injury; Pharmacologic Substance; Population; Printing; Process; Production; Property; Recovery; Research; Research Personnel; Schools; Stroke; System; Techniques; Teenagers; Temporal Lobe; Testing; Variant; Visual; Work; behavior test; cognitive ability; cognitive function; cognitive testing; developmental plasticity; examination questions; flexibility; functional outcomes; improved; language impairment; language outcome; middle cerebral artery; motor impairment; neural; neural patterning; object recognition; optimal treatments; perinatal injury; perinatal ischemic stroke; perinatal stroke; post stroke; recruit; skills; stroke recovery; young adult

PROJECT SUMMARY It has long been argued that the brain is most plastic during early development and that after brain injury, children reorganize cortical functions to healthy areas; but there is little understanding of these processes. Many investigators have shown that, when the left hemisphere (LH) is damaged, language can be subserved by the right hemisphere (RH). Here we ask how the linguistic functions of LH and RH are organized after LH injury and how well this atypical organization supports linguistic abilities. We also investigate the complementary questions regarding how these functions are organized after RH injury. We will study the long-term outcomes after ischemic perinatal stroke (IPS), due to its relatively clean properties for scientific analysis. IPS occurs in 1/4000 births and is the leading known cause of cerebral palsy. Many children with LH perinatal stroke develop near-normal language and cognitive abilities, but a substantial number show later language and cognitive impairments. Most literature shows that, after early LH stroke, language `reorganizes' to homotopic RH areas. Our pilot data suggest that, under these circumstances, typical LH and RH language functions divide up the RH cortical territory in new ways. We hypothesize that these functions develop best when different language functions find distinct RH localizations; overlap of linguistic functions will lead to more impaired performance. We will test this hypothesis by investigating language after LH perinatal injuries. We will also ask the same questions after RH perinatal injuries. We will recruit 30 teenagers and young adults who have had a LH perinatal stroke involving the middle cerebral artery and 30 who have had a similar RH perinatal stroke, compared with 30 healthy controls matched in age and SES. While IPS is rare, our research team is ideal for successful recruiting. We have developed our tasks and tested 16 children with perinatal strokes. We will administer a battery of behavioral and neuropsychological tests and 5 fMRI tasks. Two fMRI tasks (examining naming and sentence processing) test language functions that activate LH language areas in healthy controls. Two fMRI tasks (examining vocal emotion and intonation) test functions ordinarily controlled by the RH. Together these tasks examine how language abilities are affected when they develop in one hemisphere. An additional fMRI task examines specific object recognition (word recognition, ordinarily in LH VWFA, and face recognition, ordinarily in RH FFA) to ask if these functions are altered when their typical neural substrates are intact but language is shifted. Our behavioral tests assess how well all of these skills operate when neural organization is atypical. These studies will contribute to our understanding of the flexibility and limitations of early brain plasticity. In the future our findings can also help to provide a foundation for developing techniques to stimulate the most successful types of functional organization after early brain injuries.

项目摘要 长期以来一直认为，在早期发育期间，大脑是最塑性的，脑损伤后， 儿童将皮质功能重组为健康地区；但是对这些过程几乎没有理解。 许多调查人员表明，当左半球（LH）损坏时，可以对语言进行费用 右半球（RH）。在这里，我们询问LH和RH的语言功能是如何组织的 LH伤害以及这个非典型组织支持语言能力的能力。我们还调查了 RH损伤后如何组织这些功能的互补问题。 由于其相对干净 科学分析的属性。 IPS发生在1/4000个出生中，是脑瘫的主要原因。 许多患有LH围产期中风的儿童发展了近乎正常的语言和认知能力，但很重要 数字显示后来的语言和认知障碍。大多数文献表明，在LH中风较早之后， 语言“重组”到同型RH区域。我们的飞行员数据表明​​，在这种情况下 典型的LH和RH语言功能以新的方式划分了Rh Cortical领域。我们假设 当不同的语言函数找到不同的RH局部化时，这些功能会发展最佳。重叠 语言功能将导致更大的性能。我们将通过研究来检验这一假设 LH围产期受伤后的语言。 RH围产期受伤后，我们还将提出相同的问题。 我们将招募30名少年和年轻人，他们的围产期中风涉及中间 脑动脉和30例患有类似RH围产期的动脉，而30个健康对照组 年龄和SES匹配。虽然IPS很少见，但我们的研究团队是成功招募的理想选择。我们有 开发了我们的任务，并测试了16名围产期中风的儿童。我们将管理一系列的行为 和神经心理学测试和5项FMRI任务。两个fMRI任务（检查命名和句子处理） 在健康控制中激活LH语言领域的测试语言功能。两个fMRI任务（检查人声 情绪和语调）测试功能通常由RH控制。这些任务一起研究了如何 语言能力在一个半球发展时会受到影响。额外的fMRI任务检查 特定的对象识别（词识别，通常在LH VWFA中，而面部识别，通常在RH中 ffa）询问这些功能在完整的典型神经底物时是否会改变，但语言被改变。 我们的行为测试评估了神经组织非典型的所有这些技能的运作良好。 这些研究将有助于我们理解早期大脑可塑性的灵活性和局限性。 将来，我们的发现还可以帮助为开发最大的技术提供基础 早期脑损伤后成功的功能组织类型。

项目成果

Revisiting Lenneberg's Hypotheses About Early Developmental Plasticity: Language Organization After Left-Hemisphere Perinatal Stroke.

重温伦伯格关于早期发育可塑性的假设：左半球围产期中风后的语言组织。

• 发表时间: 2017
• 期刊: Biolinguistics
• 影响因子: 0.6
• 作者: Newport,ElissaL;Landau,Barbara;Seydell-Greenwald,Anna;Turkeltaub,PeterE;Chambers,CatherineE;Dromerick,AlexanderW;Carpenter,Jessica;Berl,MadisonM;Gaillard,WilliamD
• 通讯作者: Gaillard,WilliamD

In Memoriam: Alexander W. Dromerick Jr, MD, July 1, 1958-August 21, 2021.

悼念：Alexander W. Dromerick Jr，医学博士，1958年7月1日至2021年8月21日。

• DOI: 10.1161/strokeaha.122.039909
• 发表时间: 2022
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Savitz,SeanI;Newport,ElissaL;Edwards,Dorothy
• 通讯作者: Edwards,Dorothy

Interpreting the CPASS Trial: Do Not Shift Motor Therapy to the Subacute Phase.

解读 CPASS 试验：不要将运动治疗转移到亚急性阶段。

• DOI: 10.1177/15459683221143461
• 发表时间: 2023
• 期刊: Neurorehabilitation and neural repair
• 影响因子: 4.2
• 作者: Edwardson,MatthewA;Brady,Kathaleen;Giannetti,MargotL;Geed,Shashwati;Barth,Jessica;Mitchell,Abigail;Tan,MingT;Zhou,Yizhao;Bregman,BarbaraS;Newport,ElissaL;Edwards,DorothyF;Dromerick,AlexanderW
• 通讯作者: Dromerick,AlexanderW

The neural basis of language development: Changes in lateralization over age.

• DOI: 10.1073/pnas.1905590117
• 发表时间: 2020-09-22
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Olulade OA;Seydell-Greenwald A;Chambers CE;Turkeltaub PE;Dromerick AW;Berl MM;Gaillard WD;Newport EL
• 通讯作者: Newport EL

Development of bilateral parietal activation for complex visual-spatial function: Evidence from a visual-spatial construction task.

• DOI: 10.1111/desc.13067
• 发表时间: 2021-07
• 期刊: Developmental science
• 影响因子: 3.7
• 作者: Ferrara K;Seydell-Greenwald A;Chambers CE;Newport EL;Landau B
• 通讯作者: Landau B