Epidemiologic Research and Surveillance in Epilepsy (U01) Component A

癫痫流行病学研究和监测 (U01) A 部分

• 批准号: 8514942
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 40.38万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514942
• 关键词: Epidemiologic; Research; Surveillance; Epilepsy; U01

Project Summary The long-term objectives of the proposed research are to deepen our understanding of the epidemiology of pediatric epilepsy in a geographic area with a racially and economically diverse population. Children in DC are among the most racially and socioeconomically diverse populations in the country, with approximately 66% Black, 18% white, 11% Hispanic and 5% some other race. A total of 29% of all DC children live below the poverty level, and almost 50% of families are run by a single head of household. DC presents a rich population for study to formulate policies and programs to address the needs of a vulnerable and potentially underserved population. To meet our objectives, the following specific aims will be addressed: (1) determine utilization of healthcare resources, responsiveness of health systems and obstacles to care experienced by children with epilepsy and their families, (2) characterize risk factors, outcomes and comorbidities related to prevalent and new onset pediatric epilepsy, and (3) reassess population-based estimates of epilepsy incidence and prevalence over a 2-year period among children living in DC. In support of Aims 1 and 2, we propose creating a cohort of at least 500 DC children with epilepsy. We will use a self-administered questionnaire to obtain data from the parents of the pediatric cases. This questionnaire will ask questions about personal history of epilepsy, types of care sought and received, comorbidities such as cardiac disease and sleep disorders, family history of epilepsy, and the family and social environment. To supplement these data, medical records will be abstracted for treatment schedules, medication use, epilepsy phenotype, and other health measures. Follow- up data collection is expected to occur every 6 months. In support of Aim 3, we will determine whether previously obtained prevalence and incidence estimates for pediatric epilepsy are accurate and stable over time. This will be performed by using an existing health screening tool, the Behavioral Risk Factor Surveillance Survey, used to obtain data on public health in DC and across the country. We will also examine DC-mandated public school immunization records, maintained by CNMC, that also include an indicator for epilepsy, to compare estimates of epilepsy in school-age children with that found in the telephone survey. Children with epilepsy are a socially and educationally vulnerable group. Characterizing epilepsy in the DC school age population will play a role in better defining the resources needed to provide essential health and educational services to an underserved population. As a community with such rich diversity, DC is an ideal geographical area to implement population-based studies of epilepsy. Results from our study may contribute to recommendations for changes in health policy and guidelines used by primary care providers and neurologists for treatment of children with epilepsy.

项目摘要 拟议研究的长期目标是加深我们对 儿童癫痫在一个地理区域与种族和经济多样化的人口。华盛顿的孩子们 在该国种族和社会经济最多样化的人口中，约有66% 黑人，18%白色，11%西班牙裔和5%其他种族。所有DC儿童中有29%生活在 贫困程度最高，近50%的家庭由一个户主经营。华盛顿的人口丰富 研究制定政策和方案，以满足弱势群体和可能得不到充分服务的人的需要。 人口为了实现我们的目标，将处理以下具体目标：（1）确定利用 卫生保健资源、卫生系统的反应能力以及儿童在获得护理方面遇到的障碍 癫痫及其家庭，（2）表征与流行和 新发儿童癫痫，（3）重新评估基于人群的癫痫发病率估计值， 生活在华盛顿特区的儿童在2年内的患病率。为了支持目标1和2，我们建议设立 一组至少500名患有癫痫的DC儿童。我们将使用自填问卷来获取数据 儿科病例的家长这份问卷将询问有关个人历史的问题， 癫痫，寻求和接受的护理类型，心脏病和睡眠障碍等合并症，家庭 癫痫病史，家庭和社会环境。为了补充这些数据，医疗记录将 提取治疗时间表，药物使用，癫痫表型和其他健康措施。跟着- 预计每6个月进行一次向上数据收集。为了支持目标3，我们将确定 先前获得的儿童癫痫患病率和发病率估计值准确且稳定， 时间这将通过使用现有的健康筛查工具-行为风险因素监测来进行 调查，用于获取DC和全国范围内的公共卫生数据。我们还将检查DC授权的 由CNMC维护的公立学校免疫记录，其中还包括癫痫指标， 将学龄儿童癫痫的估计值与电话调查中的结果进行比较。儿童 癫痫是社会和教育上的弱势群体。在DC学龄期癫痫的特征 人口将在更好地确定提供基本卫生和教育所需的资源方面发挥作用 服务不足的人群。作为一个具有如此丰富多样性的社区，DC是一个理想的地理环境。 开展以人群为基础的癫痫病研究。我们的研究结果可能有助于 初级保健提供者和神经科医生使用的卫生政策和指南的变更建议 用于治疗儿童癫痫。