Epidemiologic Research and Surveillance in Epilepsy (U01) Component A

癫痫流行病学研究和监测 (U01) A 部分

• 批准号: 8234628
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 42.5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234628
• 关键词: Epidemiologic; Research; Surveillance; Epilepsy; U01

DESCRIPTION (provided by applicant): Project Summary The long-term objectives of the proposed research are to deepen our understanding of the epidemiology of pediatric epilepsy in a geographic area with a racially and economically diverse population. Children in DC are among the most racially and socioeconomically diverse populations in the country, with approximately 66% Black, 18% white, 11% Hispanic and 5% some other race. A total of 29% of all DC children live below the poverty level, and almost 50% of families are run by a single head of household. DC presents a rich population for study to formulate policies and programs to address the needs of a vulnerable and potentially underserved population. To meet our objectives, the following specific aims will be addressed: (1) determine utilization of healthcare resources, responsiveness of health systems and obstacles to care experienced by children with epilepsy and their families, (2) characterize risk factors, outcomes and comorbidities related to prevalent and new onset pediatric epilepsy, and (3) reassess population-based estimates of epilepsy incidence and prevalence over a 2-year period among children living in DC. In support of Aims 1 and 2, we propose creating a cohort of at least 500 DC children with epilepsy. We will use a self-administered questionnaire to obtain data from the parents of the pediatric cases. This questionnaire will ask questions about personal history of epilepsy, types of care sought and received, comorbidities such as cardiac disease and sleep disorders, family history of epilepsy, and the family and social environment. To supplement these data, medical records will be abstracted for treatment schedules, medication use, epilepsy phenotype, and other health measures. Follow- up data collection is expected to occur every 6 months. In support of Aim 3, we will determine whether previously obtained prevalence and incidence estimates for pediatric epilepsy are accurate and stable over time. This will be performed by using an existing health screening tool, the Behavioral Risk Factor Surveillance Survey, used to obtain data on public health in DC and across the country. We will also examine DC-mandated public school immunization records, maintained by CNMC, that also include an indicator for epilepsy, to compare estimates of epilepsy in school-age children with that found in the telephone survey. Children with epilepsy are a socially and educationally vulnerable group. Characterizing epilepsy in the DC school age population will play a role in better defining the resources needed to provide essential health and educational services to an underserved population. As a community with such rich diversity, DC is an ideal geographical area to implement population-based studies of epilepsy. Results from our study may contribute to recommendations for changes in health policy and guidelines used by primary care providers and neurologists for treatment of children with epilepsy.

描述(申请人提供)：项目摘要拟议研究的长期目标是加深我们对人口种族和经济多元化的地理区域内儿童癫痫流行病学的了解。哥伦比亚特区的儿童是美国种族和社会经济差异最大的人群之一，大约66%的黑人，18%的白人，11%的西班牙裔和5%的其他种族。所有DC儿童中有29%生活在贫困线以下，几乎50%的家庭由一位户主管理。华盛顿特区提供了一个丰富的人口供研究，以制定政策和方案，以满足脆弱和潜在服务不足人口的需求。为了实现我们的目标，将解决以下具体目标：(1)确定卫生保健资源的利用、卫生系统的反应能力以及癫痫儿童及其家人所经历的护理障碍；(2)确定与流行和新发的儿童癫痫有关的风险因素、结果和共病；以及(3)重新评估基于人口的对生活在DC的儿童在两年期间癫痫发病率和患病率的估计。为了支持目标1和目标2，我们建议建立一个至少500名患有癫痫的DC儿童的队列。我们将使用自填式问卷从儿科病例的父母那里获得数据。这份问卷将询问有关癫痫的个人病史、寻求和接受的护理类型、心脏病和睡眠障碍等并存疾病、癫痫家族史以及家庭和社会环境。为了补充这些数据，将提取治疗计划、用药情况、癫痫表型和其他健康措施的医疗记录。后续数据收集预计每6个月进行一次。为了支持目标3，我们将确定先前获得的儿童癫痫患病率和发病率估计是否随着时间的推移而准确和稳定。这将通过使用现有的健康筛查工具--行为风险因素监测调查来执行，该工具用于获得哥伦比亚特区和全国的公共卫生数据。我们还将检查由CNMC维护的DC强制公立学校免疫记录，其中也包括癫痫指标，以将学龄儿童癫痫的估计值与电话调查中发现的值进行比较。癫痫儿童在社会和教育方面是一个弱势群体。确定哥伦比亚特区学龄人口中癫痫的特征将在更好地确定向服务不足的人口提供基本健康和教育服务所需的资源方面发挥作用。作为一个具有如此丰富多样性的社区，华盛顿是开展癫痫人群研究的理想地理区域。我们的研究结果可能有助于建议改变初级保健提供者和神经科医生用于治疗癫痫儿童的卫生政策和指南。