Epidemiologic Research and Surveillance in Epilepsy (U01) Component A

癫痫流行病学研究和监测 (U01) A 部分

• 批准号: 8234628
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 42.5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234628
• 关键词: Epidemiologic; Research; Surveillance; Epilepsy; U01

DESCRIPTION (provided by applicant): Project Summary The long-term objectives of the proposed research are to deepen our understanding of the epidemiology of pediatric epilepsy in a geographic area with a racially and economically diverse population. Children in DC are among the most racially and socioeconomically diverse populations in the country, with approximately 66% Black, 18% white, 11% Hispanic and 5% some other race. A total of 29% of all DC children live below the poverty level, and almost 50% of families are run by a single head of household. DC presents a rich population for study to formulate policies and programs to address the needs of a vulnerable and potentially underserved population. To meet our objectives, the following specific aims will be addressed: (1) determine utilization of healthcare resources, responsiveness of health systems and obstacles to care experienced by children with epilepsy and their families, (2) characterize risk factors, outcomes and comorbidities related to prevalent and new onset pediatric epilepsy, and (3) reassess population-based estimates of epilepsy incidence and prevalence over a 2-year period among children living in DC. In support of Aims 1 and 2, we propose creating a cohort of at least 500 DC children with epilepsy. We will use a self-administered questionnaire to obtain data from the parents of the pediatric cases. This questionnaire will ask questions about personal history of epilepsy, types of care sought and received, comorbidities such as cardiac disease and sleep disorders, family history of epilepsy, and the family and social environment. To supplement these data, medical records will be abstracted for treatment schedules, medication use, epilepsy phenotype, and other health measures. Follow- up data collection is expected to occur every 6 months. In support of Aim 3, we will determine whether previously obtained prevalence and incidence estimates for pediatric epilepsy are accurate and stable over time. This will be performed by using an existing health screening tool, the Behavioral Risk Factor Surveillance Survey, used to obtain data on public health in DC and across the country. We will also examine DC-mandated public school immunization records, maintained by CNMC, that also include an indicator for epilepsy, to compare estimates of epilepsy in school-age children with that found in the telephone survey. Children with epilepsy are a socially and educationally vulnerable group. Characterizing epilepsy in the DC school age population will play a role in better defining the resources needed to provide essential health and educational services to an underserved population. As a community with such rich diversity, DC is an ideal geographical area to implement population-based studies of epilepsy. Results from our study may contribute to recommendations for changes in health policy and guidelines used by primary care providers and neurologists for treatment of children with epilepsy.

描述（由申请人提供）：项目摘要拟议的研究的长期目标是加深我们对具有种族和经济多样化人群的地理区域中儿科癫痫的流行病学的理解。华盛顿特区的儿童是该国种族和社会经济上最多样化的人群之一，黑色约为66％，白人18％，11％的西班牙裔和5％的其他种族。总共有29％的DC儿童生活在贫困水平以下，几乎50％的家庭由一个家庭负责人经营。 DC提供了众多的研究人群，以制定政策和计划，以满足脆弱且潜在服务不足的人群的需求。为了实现我们的目标，将解决以下具体目标：（1）确定医疗资源的利用，卫生系统的反应能力以及癫痫病及其家人的儿童经历的护理障碍，（2）特征的风险因素，结果和合并症，与普遍和新的发作性癫痫发作相关的疾病，以及（3）在Eprics epelepssips and Interces and Interces and Eprice epile epile epile epile epile epils and Epriles abterssiption a in 2年度的估算率均为（3）在DC。为了支持目标1和2，我们提议创建至少500名DC癫痫病儿童的队列。我们将使用自我管理的问卷来获取儿科病例父母的数据。该问卷将询问有关癫痫的个人历史，寻求和接受的护理类型的问题，诸如心脏病和睡眠障碍，癫痫家族史以及家庭和社会环境等合并症。为了补充这些数据，将为治疗时间表，药物使用，癫痫表型和其他健康措施提取医疗记录。随访数据收集预计将每6个月进行一次。为了支持AIM 3，我们将确定先前获得的小儿癫痫病的患病率和发病率估计是否准确稳定。这将通过使用现有的健康筛查工具，即行为风险因素监视调查，用于获取DC和全国公共卫生的数据。我们还将研究由CNMC维持的DC规定的公立学校免疫记录，其中还包括癫痫的指标，以比较学校时代儿童癫痫的估计与电话调查中发现的估计。癫痫患者是一个社会和教育脆弱的群体。在DC学校年龄人口中癫痫的表征将在更好地定义为服务不足的人群提供基本健康和教育服务所需的资源方面发挥作用。作为一个具有如此丰富多样性的社区，DC是实施基于人群的癫痫研究的理想地理领域。我们研究的结果可能有助于对卫生政策的变化以及初级保健提供者和神经科医生使用的指南的建议，以治疗癫痫儿童。