QMRA IV- Quantitative Microbial Risk Assessment Interdisciplinary Vehicle: Addressing Emerging Global Health Risks

项目摘要/摘要 定量微生物风险评估(QMRA)是一个针对微生物暴露的研究领域 病原体和传染病过程，以确定对人类健康的影响。它已经成为一种 建立健康风险预测性和回溯性评估的良好框架。QMRA是一种翻译 需要综合数学、统计学、生物学、工程学和公共科学知识的科学 健康。尽管QMRA很复杂，但对于解决在 多学科生物医学界--公共卫生、应急响应、环境控制措施、 净化、工业卫生和医疗对策。接触致病微生物 感染和随后的发展是与显著的变异性和 整个人口的不确定性，这也必须进行沟通，以便有效地管理风险。自.以来 风险科学本质上是跨学科的，在贡献学科中很少有项目提供课程和 QMRA方面的培训。通过前期工作，我们增加了培训、模型和工具， 在生物医学界全面参与的障碍仍然存在，特别是在指导和 外展。我们的长期目标是提高生物医学和行为科学家的能力：(I) 纳入并促进与其研究有关的微生物风险评估；和(2)增加其 有能力领导和参与与微生物风险相关的各种跨学科团队科学项目。这个 该项目的目标是为生物医学界提供有关微生物风险的全面培训。 科学，循证指导方法，以支持纳入和参与来自 不同的背景和数据/计算平台，以促进更深入的学习和QMRA实践。 拟议的项目建立在由美国国立卫生研究院资助的几个成功的为期十天的课程的基础上。 QMRAIII计划(2014至2018)和之前为期一周的强化课程 微生物风险评估中心)从2006年到2011年。每年，有更多的 申请者超过允许的入学人数；以及职业生涯中期和高级教职员工通常被排除在 优先考虑早期职业研究人员。我们的评估和评估支持我们的实践模式 达到学习目标。然而，整个生物医学界的贡献平衡将是 通过持续的指导和外展机会大大加强，这些机会是对 该课程还为未来的实习生和教育工作者提供了一个在线平台。

Project Summary/Abstract Quantitative microbial risk assessment (QMRA) is a research domain that addresses exposures to microbial pathogens and infectious disease processes in order to characterize human health effects. It has become a well-established framework for predictive and retrospective evaluations of health risks. QMRA is a translational science requiring integration of knowledge from mathematics, statistics, biology, engineering, and public health. Though complex, QMRA is highly useful for addressing societal problems encountered within the multidisciplinary biomedical community - public health, emergency response, environmental control measures, decontamination, industrial hygiene and medical countermeasures. Exposure to microbial agents of disease and subsequent development of infection are dynamic processes associated with substantial variability and uncertainty across the population, which must also be communicated in order to effectively manage risk. Since risk science is inherently interdisciplinary, few programs in the contributing disciplines offer courses and training in QMRA. Though training, models and tools have increased as the result of our preliminary work, barriers to full participation across the biomedical community still exists especially needs in mentoring and outreach. Our long term goals are to increase the capability for biomedical and behavioral scientists: (i) to incorporate and contribute to microbial risk assessments related to their research; and (ii) to increase their ability to lead and contribute to diverse, interdisciplinary team science projects related to microbial risks. The objective of this project is to provide the biomedical community with comprehensive training in microbial risk sciences, evidence-based mentoring approaches to support inclusion and participation of scientists from diverse backgrounds and a data/computational platform to facilitate deeper learning and the QMRA practice. The proposed project builds upon several, successful, ten-day courses offered through the NIH funded QMRAIII program (2014 to 2018) and previous one week-long, intensive courses conducted through the Center for Advancing Microbial Risk Assessment) from 2006 to 2011. Each year, there were significantly more applicants than allowable enrollment; and mid-career and senior faculty members were generally excluded to prioritize early career researchers. Our evaluations and assessments support our model of practice for reaching learning objectives. However, the balance of contributions across the biomedical community would be greatly enhanced through sustained mentoring and outreach opportunities which are complementary to the course as well as an online platform for future trainees and educators.