Wake Forest IMPOWR Dissemination Education and Coordination Center (IDEA-CC)

项目概要 慢性疼痛 (CP) 和阿片类药物使用障碍 (OUD) 患者经历孤立的临床路径， 破坏这两种情况的治疗。认识到临床和研究将 CP 和 OUD 分开 NIH NIDA 和 HEAL Initiative 正在针对面临疼痛治疗不足和 OUD 不良结果风险的患者 重点是开发综合评估和治疗途径。为了有效地涵盖 通过 IMPOWR 计划制定的务实临床举措，该提案响应了 CP 的号召 OUD 重点传播和协调中心。 IMPOWR 传播、教育和 协调中心 (IDEA-CC) 将开发以 CP 和 OUD 为重点的基础设施支持，以扩大和 为 IMPOWR 和其他相关研究网络的发现创造动力。建立在现有的基础上 工作中，我们的提案将通过几个关键领域开发 IMPOWR 网络的基础设施：1) 快速部署通信框架，将 IMPOWR 临床站点彼此以及更大的 HEAL 连接起来 研究框架； 2) 发展教育基础设施，解决耻辱和健康差距问题 患有 CP 和 OUD 共病的患者； 3) 向目标受众有效传播研究成果。 拟议研究的基本原理是了解共病 CP 和 OUD 之间的关系 对于设计最有效的干预措施至关重要。 IDEA-CC 的目标是创建一个研究 连接 IMPOWR 中心以转化研究结果并开发关键 CP-OUD 研究和 教育基础设施。我们的中心假设是改善共病 CP 和 OUD 治疗将 涉及综合临床方法，以及我们医疗保健教育方式的根本转变 提供者和社区。我们将通过几个目标来实现这一目标。目标 1：协调流程 IMPOWR 研究中心的 CP 和 OUD 措施的数据收集和通用数据元素， 提供一个协调平台来收集这些研究的数据。目标2：双向传播 有关网络研究和向更大的科学界共享数据的机会的信息，以及 疼痛、成瘾和心理健康领域的社区合作伙伴。目标 3：支持 IMPOWR 网络 开发和验证综合 CP 和 OUD 措施的关键工具/措施。目标 4： 开发教育基础设施，解决 CP 和 OUD 共病的耻辱和健康差异。 这项工作具有创新性，因为能够设计由 PROMIS 专业知识和地图支持的措施 将数据验证到更大的研究框架。维克森林大学 IDEA-CC 将创建一项共享研究 平台，以放大和加速 CP 和 OUD 接口处的调查。这项研究将支持 NIH NIDA 的目标是增强现有治疗方法在 OUD 和 CP 关键交叉点的临床影响 条件，同时积极努力以促进健康公平的方式消除治疗的污名化。

Project Summary People with chronic pain (CP) and opioid use disorder (OUD) experience siloed clinical pathways that undermine treatment for both conditions. Recognizing that clinical and research separate CP and OUD leaves patients at risk for undertreated pain and detrimental OUD outcomes, NIH NIDA and the HEAL Initiative are focused on developing integrated assessment and treatment pathways. In order to effectively encompass the pragmatic clinical initiatives developing though the IMPOWR program, this proposal answers the call for a CP and OUD focused dissemination and coordination center. The IMPOWR Dissemination, Education, and Coordination Center (IDEA-CC) will develop a CP and OUD focused infrastructure support to amplify, and create momentum for the findings of IMPOWR and other linked research networks. Building on existing work, our proposal will develop the infrastructure for the IMPOWR network through several key domains: 1) rapidly deploy a communication framework to link IMPOWR clinical sites with each other and the larger HEAL research framework; 2) develop an educational infrastructure addressing stigma and health disparities in patients with co-morbid CP and OUD; and 3) effectively disseminate research findings to targeted audiences. The rationale for the proposed research is that understanding the relationship between co-morbid CP and OUD is critical to designing the most effective interventions. The objective of the IDEA-CC is to create a research community that connects IMPOWR centers to translate findings and develop a key CP-OUD research and education infrastructure. Our central hypothesis is that improving co-morbid CP and OUD treatment will involve integrated clinical approaches, and a fundamental shift in how we educate healthcare providers and the community. We will achieve this through several aims. Aim 1: Harmonize processes for data collection and common data elements of CP and OUD measures across the IMPOWR research center, providing a coordinated platform for gathering data from these studies. Aim 2: Bidirectionally disseminate information regarding network research and data sharing opportunities to the larger scientific community and community partners in the fields of pain, addiction, and mental health. Aim 3: Support IMPOWR network development and the validation of key instruments/measures of composite CP and OUD measures. Aim 4: Develop an educational infrastructure that addresses stigma and health disparities for co-morbid CP and OUD. This work is innovative because of the ability to design measures supported by PROMIS expertise and map validated data to larger research frameworks. The Wake Forest IDEA-CC will create a shared research platform to amplify and accelerate investigations at the interface of CP and OUD. This research will support NIH NIDA's goal to enhance the clinical impact of existing treatments at the critical intersection of OUD and CP conditions, while actively working to destigmatize treatment in a way that promotes health equity.