WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder

WF DISC：慢性疼痛和阿片类药物使用障碍的数据解决方案导航

• 批准号: 10708945
• 负责人: MEREDITH C. B. ADAMS
• 金额: $ 155万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708945
• 关键词: Acceleration; Adoption; Agreement; Biology; Clinical; Clinical Informatics; Clinical Research; Clinical Trials; Communication; Communities; Consent; Creativeness; Data; Data Analyses; Data Analytics; Data Collection; Data Linkages; Data Sources; Development; Dimensions; Disease; Economics; Education; Electronic Health Record; Elements; Epidemic; FAIR principles; Funding; Future; Goals; Health system; Human; Individual; Informatics; Information Dissemination; Infrastructure; Institutional Review Boards; Intervention; Investigation; Joints; Knowledge; Language; Learning; Libraries; Measurement; Measures; Mission; Modeling; Modernization; Monitor; National Institute of Drug Abuse; Outcome; Outcomes Research; Overdose; Pain; Phase; Positioning Attribute; Prevention strategy; Protocols documentation; Public Health; Qualifying; Randomized, Controlled Trials; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Resources; Services; Site; Standardization; System; Techniques; Time; Training; Training Support; Translating; United States National Institutes of Health; Validation; Visual; Visualization; Work; chronic pain; complex data; data centers; data ecosystem; data harmonization; data infrastructure; data management; data visualization; design; experience; flexibility; health goals; improved; informatics infrastructure; informatics tool; innovation; insight; interoperability; large datasets; novel; opioid overdose; opioid use disorder; overdose prevention; prevent; programs; prospective; response; service delivery; time use; tool; trend; trial design

PROJECT SUMMARY The multidimensional challenge of opioid overdose prevention requires solutions larger than a single network project. While the HHS and NIH are focusing on developing prevention strategies from numerous perspectives, blending these data will require complex data solutions to move beyond siloes. While we do not know yet how bringing the elements of opioid overdose data together will be most effective, collecting these data in ways that allow for FAIR (Findable, Accessible, Interoperable, Reusable) formatting builds toward that potential. The goal of the HEAL D2A program is to develop opioid overdose surveillance in real time, but it going to take significant combined clinical and informatics knowledge to bring this system together. To accomplish this goal, our proposal is responsive to RFA-DA-22-052 to design flexible and creative informatics solutions for the HEAL Data2Action program (HD2A) network. The WF Data Infrastructure Support Center (DISC)'s highly qualified clinical informatics team will provide direct support, guidance, and assistance to ensure that data infrastructures of the highest quality are produced in the shortest possible time for the HEAL D2A Innovation Projects. Our overall goal as a U24 Data Center is to identify and eliminate data infrastructure barriers (knowledge and technical) to allow successful completion of the HD2A projects. The objective of this proposal is to navigate the expected and unexpected data challenges for the HD2A network, encompassing the Innovation projects to identify tools, provide data support, and deliver training assistance. We will accomplish this objective through successful completion of these phased aims. To support the overall hypothesis of the HEAL D2A network, in Aim 1, the WF DISC's Study Start-up Core will identify and develop data infrastructure support and tools. In Aim 2, WF DISC's Study Conduct Core will work with the HD2A RASC and MERC provide data measurement, analytical, and visualization support and coordination. In Aim 3, The WF DISC's Study Dissemination Core will develop and provide data training and resources. In Aim 4, we will identify rapid data infrastructure modernization support (Rapid DIMS) needs and provide programmatic resources. At the successful completion of the proposed research, the expected outcomes are centralized support, resources, and coordination of all data-related needs for the HEAL HD2A Innovation Projects. The proposed research is innovative because adaptation of our team's experience will bridge clinical research and informatics infrastructure to provide logistical, scientific, oversight, and technical support for data collection, curation, reporting, and management by the HD2A Innovation Projects. These results will provide a strong basis for further/future development of opioid overdose prevention surveillance, which is expected to have a significant impact on overdose by allowing for rapid intervention and pivoting of resources. This research aligns with NIH NIDA and HEAL's goals to prevent and mitigate the impact of the OUD epidemic.

项目总结