MIRHIQL Resource Center for Improving Quality of Life with Chronic Pain (MRC)
MIRHIQL 改善慢性疼痛生活质量资源中心 (MRC)
基本信息
- 批准号:10705887
- 负责人:
- 金额:$ 597.81万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-15 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdvisory CommitteesAffectBehaviorBenefits and RisksCaringCategoriesClinicalClinical ResearchCommon Data ElementCommunitiesComplexConsensusDataData AnalysesData CollectionDiagnosticEcosystemElementsEnvironmental Risk FactorExpert OpinionFoundationsGoalsHealth PersonnelHealth PolicyIndividualInfrastructureInstitutionInterventionInterviewKnowledgeLinkMeasuresMedicineMissionOpioidOutcomeOutcomes ResearchPainPatientsPatternPersonsPhenotypePoliciesPrivatizationProcessProviderPublic HealthQuality of lifeResearchResourcesRisk AssessmentSocietiesSystemTestingTranslatingTreatment outcomeUnited States National Institutes of HealthValidationVulnerable PopulationsWorkchronic painchronic painful conditionclinical careclinical centerclinical practiceclinically relevantcohortdata harmonizationdata sharingdisorder preventioneHealthelectronic health dataexperiencefunctional statushealth care deliveryhealth datahealth equity promotionimprovedinnovationopioid abuseopioid misuseopioid therapyopioid useopioid use disorderpatient orientedpersonalized carepersonalized medicineprescription opioidprocess evaluationresearch studyscreeningsocial health determinantssupport networksupport toolssystematic reviewtimelinetooltool developmenttreatment adherencetrial comparingusability
项目摘要
Project Summary
Despite acknowledging the challenges of long-term opioid use (LTOT) in clinical and research studies, there is
no consensus on clinically defining opioid misuse. In clinical practice, screening and risk/benefit calculations
remain difficult because while opioid use can be problematic, it may be beneficial in certain subpopulations.
The combination of variables that could be used clinically to assess the risk of harms versus quality of life for
people on LTOT has not been established. It may be possible to decrease some of the tension between
prescribers and patients if clinical providers have a working clinical definition and improved ways of assessing
whether a patient is a candidate for LTOT. The MIRHIQL Resource Center's (MRC) long-term goal is to
understand how chronic pain (CP) and related factors influence the progression of LTOT behaviors. The
objective of MRC center is to create a research community that connects the MIRHIQL network to IMPOWR
research centers and larger HEAL network to translate findings while developing a key opioid misuse and
LTOT infrastructure. We hypothesize that defining opioid misuse and the LTOT benefit/risk framework will
require integrated patient-centered clinical approaches that address the systemic issues affecting healthcare
delivery and the patient-provider interaction, leading to a fundamental shift in how healthcare providers and the
public are educated. These goals will be achieved through the following specific aims: (1) the MRC will
harmonize data collection and common data elements for the MIRHIQL network, providing coordinated support
for network activities while connecting to the IMPOWR Network and larger HEAL Ecosystem via our IMPOWR
CC, (2) The MRC will clinically define opioid misuse with associated risks/benefits using an interconnected
strategy including multi-society expert Delphi, qualitative interviewing of prescribers and people with lived pain
experience, and phenotyping and validating cohort definitions in electronic health and administrative claims
data, and (3) The MRC will perform analytical and clinical validation of screening and benefit/risk tools for
LTOT and definition of opioid misuse in a cohort trial comparing different combinations of relevant OM
variables. Usability (system/provider input) and user experience (provider/patient input) will evaluated for
clinical utility in real-world clinical settings. These aims will provide a coordinated integration of systematic
review, qualitative interviewing, EHR and claims data, and expert Delphi Taskforce to identify and test
candidate variables for a clinical definition of opioid misuse and develop screening and risk/benefit tools for
clinical care. The proposed research is innovative because we will be able to leverage the large-scale claims
(CMS and private payer) and EHR data to build a framework for LTOT care on a rapid timeline. These results
will support future research but will also have direct clinical impact, aligning with NIH HEAL's mission.
项目摘要
尽管承认长期使用阿片类药物(LTOT)在临床和研究中存在挑战,但
在临床定义阿片类药物滥用方面没有达成共识。在临床实践中,筛查和风险/收益计算
仍然很困难,因为尽管阿片类药物的使用可能会有问题,但它可能对某些亚群有益。
可用于临床评估伤害风险与生活质量的变量组合
LTOT上的人还没有建立起来。也许有可能减少两国之间的紧张关系
如果临床提供者有有效的临床定义和改进的评估方法,处方医生和患者
患者是否为LTOT的候选患者。MIRHIQL资源中心的长期目标是
了解慢性疼痛(CP)及相关因素如何影响LTOT行为的进展。这个
MRC中心的目标是创建一个将MIRHIQL网络与IMPOWR连接起来的研究社区
研究中心和更大的Hear网络将研究结果转化为开发关键的阿片类药物滥用和
LTOT基础设施。我们假设,定义阿片类药物滥用和LTOT益处/风险框架将
需要以患者为中心的综合临床方法,以解决影响医疗保健的系统性问题
提供服务和患者-提供者互动,导致医疗保健提供者和
公众是受过教育的。这些目标将通过以下具体目标实现:(1)管理资源中心将
协调MIRHIQL网络的数据收集和公共数据元素,提供协调支持
在通过我们的IMPOWR连接到IMPOWR网络和更大的医疗生态系统的同时进行网络活动
CC,(2)MRC将在临床上定义阿片类药物滥用及其相关风险/好处
策略包括多社会专家Delphi,对处方者和生活痛苦患者的定性访谈
经验,以及电子健康和行政索赔中的表型和验证队列定义
数据,以及(3)MRC将执行筛查和收益/风险工具的分析和临床验证
LTOT和阿片类药物滥用定义在一项比较相关OM不同组合的队列试验中的应用
变量。将评估可用性(系统/提供商输入)和用户体验(提供商/患者输入)
在真实世界的临床环境中的临床效用。这些目标将提供系统性的协调整合
评审、定性访谈、EHR和索赔数据,以及专家Delphi Taskforce以确定和测试
阿片类药物滥用的临床定义的候选变量,并开发筛查和风险/益处工具
临床护理。拟议的研究具有创新性,因为我们将能够利用大规模索赔
(CMS和私人付款人)和EHR数据,以快速建立LTOT护理框架。这些结果
将支持未来的研究,但也将产生直接的临床影响,与NIH Hear的使命一致。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MEREDITH C. B. ADAMS其他文献
MEREDITH C. B. ADAMS的其他文献
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{{ truncateString('MEREDITH C. B. ADAMS', 18)}}的其他基金
COVID-19 Pandemic Mitigation, Community Economic and Social Vulnerability, and Opioid Use Disorder
COVID-19 流行病缓解、社区经济和社会脆弱性以及阿片类药物使用障碍
- 批准号:
10653238 - 财政年份:2022
- 资助金额:
$ 597.81万 - 项目类别:
WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder
WF DISC:探索慢性疼痛和阿片类药物使用障碍的数据解决方案
- 批准号:
10587594 - 财政年份:2022
- 资助金额:
$ 597.81万 - 项目类别:
WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder
WF DISC:慢性疼痛和阿片类药物使用障碍的数据解决方案导航
- 批准号:
10708945 - 财政年份:2022
- 资助金额:
$ 597.81万 - 项目类别:
Wake Forest IMPOWR Dissemination Education and Coordination Center (IDEA-CC)
维克森林 IMPOWR 传播教育和协调中心 (IDEA-CC)
- 批准号:
10601172 - 财政年份:2022
- 资助金额:
$ 597.81万 - 项目类别:
Wake Forest IMPOWR Dissemination Education and Coordination Center (IDEA-CC)
维克森林 IMPOWR 传播教育和协调中心 (IDEA-CC)
- 批准号:
10665746 - 财政年份:2021
- 资助金额:
$ 597.81万 - 项目类别:
Wake Forest IMPOWR Dissemination Education and Coordination Center (IDEA-CC)
维克森林 IMPOWR 传播教育和协调中心 (IDEA-CC)
- 批准号:
10378786 - 财政年份:2021
- 资助金额:
$ 597.81万 - 项目类别:
Wake Forest IMPOWR Dissemination Education and Coordination Center (IDEA-CC)
维克森林 IMPOWR 传播教育和协调中心 (IDEA-CC)
- 批准号:
10866836 - 财政年份:2021
- 资助金额:
$ 597.81万 - 项目类别:
Wake Forest IMPOWR Dissemination Education and Coordination Center (IDEA-CC)
维克森林 IMPOWR 传播教育和协调中心 (IDEA-CC)
- 批准号:
10593312 - 财政年份:2021
- 资助金额:
$ 597.81万 - 项目类别:
Identifying opioid response phenotypes in low back pain electronic health data
识别腰痛电子健康数据中的阿片类药物反应表型
- 批准号:
9313544 - 财政年份:2017
- 资助金额:
$ 597.81万 - 项目类别:
Identifying opioid response phenotypes in low back pain electronic health data
识别腰痛电子健康数据中的阿片类药物反应表型
- 批准号:
9897632 - 财政年份:2017
- 资助金额:
$ 597.81万 - 项目类别:
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Standard Grant














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