WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder

WF DISC：探索慢性疼痛和阿片类药物使用障碍的数据解决方案

• 批准号: 10587594
• 负责人: MEREDITH C. B. ADAMS
• 金额: $ 155万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10587594
• 关键词: Acceleration; Adoption; Agreement; Biology; Clinical Informatics; Clinical Research; Clinical Trials; Communication; Communities; Community Health Systems; Consent; Data; Data Analyses; Data Analytics; Data Collection; Data Linkages; Data Sources; Development; Disease; Economics; Education; Electronic Health Record; Elements; Ensure; Epidemic; FAIR principles; Funding; Future; Goals; Human; Individual; Informatics; Information Dissemination; Infrastructure; Institutional Review Boards; Intervention; Investigation; Joints; Knowledge; Language; Learning; Libraries; Logistics; Measurement; Measures; Mission; Modeling; Modernization; Monitor; National Institute of Drug Abuse; Outcome; Outcomes Research; Overdose; Pain; Phase; Positioning Attribute; Prevention strategy; Protocols documentation; Public Health; Randomized Controlled Trials; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Resources; Services; Site; Sleep Initiation and Maintenance Disorders; Standardization; System; Techniques; Time; Training; Training Support; Translating; United States National Institutes of Health; Validation; Visual; Visualization; Work; chronic pain; complex data; data centers; data ecosystem; data harmonization; data infrastructure; data management; data visualization; design; experience; flexibility; health goals; improved; informatics infrastructure; informatics tool; innovation; insight; interoperability; large datasets; novel; opioid overdose; opioid use disorder; overdose prevention; prevent; programs; prospective; response; service delivery; support tools; time use; tool; trend; trial design

PROJECT SUMMARY The multidimensional challenge of opioid overdose prevention requires solutions larger than a single network project. While the HHS and NIH are focusing on developing prevention strategies from numerous perspectives, blending these data will require complex data solutions to move beyond siloes. While we do not know yet how bringing the elements of opioid overdose data together will be most effective, collecting these data in ways that allow for FAIR (Findable, Accessible, Interoperable, Reusable) formatting builds toward that potential. The goal of the HEAL D2A program is to develop opioid overdose surveillance in real time, but it going to take significant combined clinical and informatics knowledge to bring this system together. To accomplish this goal, our proposal is responsive to RFA-DA-22-052 to design flexible and creative informatics solutions for the HEAL Data2Action program (HD2A) network. The WF Data Infrastructure Support Center (DISC)'s highly qualified clinical informatics team will provide direct support, guidance, and assistance to ensure that data infrastructures of the highest quality are produced in the shortest possible time for the HEAL D2A Innovation Projects. Our overall goal as a U24 Data Center is to identify and eliminate data infrastructure barriers (knowledge and technical) to allow successful completion of the HD2A projects. The objective of this proposal is to navigate the expected and unexpected data challenges for the HD2A network, encompassing the Innovation projects to identify tools, provide data support, and deliver training assistance. We will accomplish this objective through successful completion of these phased aims. To support the overall hypothesis of the HEAL D2A network, in Aim 1, the WF DISC's Study Start-up Core will identify and develop data infrastructure support and tools. In Aim 2, WF DISC's Study Conduct Core will work with the HD2A RASC and MERC provide data measurement, analytical, and visualization support and coordination. In Aim 3, The WF DISC's Study Dissemination Core will develop and provide data training and resources. In Aim 4, we will identify rapid data infrastructure modernization support (Rapid DIMS) needs and provide programmatic resources. At the successful completion of the proposed research, the expected outcomes are centralized support, resources, and coordination of all data-related needs for the HEAL HD2A Innovation Projects. The proposed research is innovative because adaptation of our team's experience will bridge clinical research and informatics infrastructure to provide logistical, scientific, oversight, and technical support for data collection, curation, reporting, and management by the HD2A Innovation Projects. These results will provide a strong basis for further/future development of opioid overdose prevention surveillance, which is expected to have a significant impact on overdose by allowing for rapid intervention and pivoting of resources. This research aligns with NIH NIDA and HEAL's goals to prevent and mitigate the impact of the OUD epidemic.

项目摘要 阿片类药物过量预防的多维挑战需要大于单个网络的解决方案 项目。尽管HHS和NIH专注于从许多角度制定预防策略，但 混合这些数据将需要复杂的数据解决方案以超越筒仓。虽然我们还不知道如何 将阿片类药物过量数据的元素聚集在一起将是最有效的，以这些方式收集这些数据 允许公平（可访问，可访问，可互操作，可重复使用）格式化为该潜力。目标 D2A治疗计划是实时开发阿片类药物过量监测，但这将需要大量 将临床和信息学知识结合在一起，以将该系统融合在一起。为了实现这一目标，我们 提案对RFA-DA-22-052的响应敏感，为治疗设计灵活而创意的信息解决方案 Data2Action程序（HD2A）网络。 WF数据基础架构支持中心（DISC）的高素质 临床信息学团队将提供直接支持，指导和帮助，以确保数据 最高质量的基础架构是在最短的时间内进行D2A创新的 项目。我们作为U24数据中心的总体目标是识别和消除数据基础架构障碍 （知识和技术）允许成功完成HD2A项目。该提议的目的 是浏览HD2A网络的预期和意外数据挑战，包括 创新项目以识别工具，提供数据支持并提供培训帮助。我们将完成 通过成功完成这些分阶段目标，这一目标。支持总体假设 治愈D2A网络，在AIM 1中，WF Disc的研究启动核心将识别和开发数据基础架构 支持和工具。在AIM 2中，WF Disc的研究行为核心将与HD2A RASC和MERC一起使用 提供数据测量，分析和可视化支持和协调。在AIM 3中，WF光盘的 研究传播核心将开发并提供数据培训和资源。在AIM 4中，我们将确定快速 数据基础架构现代化支持（快速DIM）需求并提供程序化资源。在 成功完成拟议的研究，预期的结果是集中的支持，资源， 以及对HED HD2A创新项目的所有与数据相关的需求的协调。拟议的研究是 创新性是因为适应我们团队的经验将弥合临床研究和信息学 为数据收集，策展提供后勤，科学，监督和技术支持的基础架构， HD2A创新项目的报告和管理。这些结果将为 阿片类药物过量预防监视的进一步/未来开发，预计将具有重要的 通过允许快速干预和枢纽资源来影响过量。这项研究与NIH保持一致 NIDA和HEAL的目标是预防和减轻OUD流行的影响。