Mechanisms underlying resilience to neighborhood disadvantage
抵御邻里劣势的潜在机制
基本信息
- 批准号:10601548
- 负责人:
- 金额:$ 34.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAgeArchitectureBrainChildChronicCommunitiesCompetenceDevelopmentDisadvantagedEpigenetic ProcessEtiologyFunctional Magnetic Resonance ImagingGenetic ProcessesJointsMental HealthMethodologyModelingNatureNeurosciencesOutcomeParentsPathway interactionsProcessPsychopathologyResearchRestRiskSamplingShapesTimeTwin Multiple BirthWorkYouthbiobehaviorcommunity-level factorneighborhood disadvantageneural networkneurobehavioralneuroimagingprotective factorsrelating to nervous systemresiliencesocioeconomicsstressor
项目摘要
Decades of research have confirmed the damaging effects of neighborhood disadvantage on
physical, socioeconomic, and mental health outcomes. Even so, many children growing up in
disadvantaged neighborhood contexts demonstrate adaptive competence. How do children achieve
these resilient outcomes in the face of such adversity? Extant studies indicate that familial- and
community-level factors protect these children from the many stressors found in disadvantaged
neighborhoods. Very little work, however, has considered the neurobehavioral pathways through
which these protective processes confer resilience. The proposed UG3/UH3 will do just this,
identifying neural markers of resilience and illuminating the multilevel epigenetic, environmental, and
genetic processes through which protective factors promote these neuro-resilient pathways. We
propose to re-assess a sample of 500 adolescent twin pairs (at age 11-16 years; previously assessed
between ages 6 and 10) residing in modestly-to-severely disadvantaged neighborhoods. We will
employ cutting-edge neuroimaging methodologies (i.e., joint models that bridge task and resting fMRI,
DTI, and sMRI) to identify the synergistic neural networks that are associated with resilience
(operationalized here as adaptive competence and the absence of psychopathology), while also
capitalizing on the longitudinal and genetically-informed nature of our unique `at-risk' twin sample to
illuminate the etiologic processes underlying neural markers of resilience. We specifically postulate
that, by protecting youth from the stressors presents in disadvantage contexts, positive parents and
communities enable children to develop the normative neural architecture that undergirds subsequent
adaptive outcomes, even in the face of adversity. Our genetically-informed developmental
neuroscience approach will thus provide an unprecedented opportunity to illuminate the multilevel
biobehavioral pathways leading to resilience, and in this way, fundamentally advance our
understanding of adaptation in the face of chronic adversity.
几十年的研究已经证实了邻里劣势的破坏性影响,
身体、社会经济和心理健康结果。即便如此,许多在美国长大的孩子
弱势社区环境表现出适应能力。儿童如何实现
在面对这样的逆境时,这些有弹性的结果?现有的研究表明,
社区层面的因素保护这些儿童免受弱势群体中的许多压力因素的影响。
邻里关系然而,很少有工作考虑到神经行为通路,
这些保护过程赋予了恢复力。拟议中的UG3/UH3将做到这一点,
确定恢复力的神经标记,并阐明多层次的表观遗传,环境,
保护性因素通过遗传过程促进这些神经弹性通路。我们
我建议重新评估500对青少年双胞胎的样本(年龄在11 - 16岁;以前评估过
6至10岁之间)居住在中度至重度弱势社区。我们将
采用尖端的神经成像方法(即,连接任务和静息功能磁共振成像的联合模型,
DTI和sMRI)来识别与恢复力相关的协同神经网络
(在这里操作为适应能力和精神病理学的缺乏),同时也
利用我们独特的"高危"双胞胎样本的纵向和遗传信息性质,
阐明了恢复力的神经标志物的病因学过程。我们特别假设
通过保护青年免受不利环境中的压力,积极的父母和
社区使儿童能够发展规范的神经结构,
适应性结果,即使面对逆境。我们的基因信息发育
因此,神经科学的方法将提供一个前所未有的机会,阐明多层次的
通过这种方式,从根本上促进我们的
理解在面对长期逆境时的适应。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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S. Alexandra Burt其他文献
S. Alexandra Burt的其他文献
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{{ truncateString('S. Alexandra Burt', 18)}}的其他基金
The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.
邻里劣势对青少年冒险行为的甲基组学后果。
- 批准号:
10293757 - 财政年份:2021
- 资助金额:
$ 34.45万 - 项目类别:
The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.
邻里劣势对青少年冒险行为的甲基组学后果。
- 批准号:
10454231 - 财政年份:2021
- 资助金额:
$ 34.45万 - 项目类别:
Quantifying the contributions of mitochondrial DNA to Alzheimer's Disease and related conditions of aging
量化线粒体 DNA 对阿尔茨海默病和相关衰老状况的影响
- 批准号:
10269143 - 财政年份:2021
- 资助金额:
$ 34.45万 - 项目类别:
The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.
邻里劣势对青少年冒险行为的甲基组学后果。
- 批准号:
10625540 - 财政年份:2021
- 资助金额:
$ 34.45万 - 项目类别:
Mechanisms underlying resilience to neighborhood disadvantage
抵御邻里劣势的潜在机制
- 批准号:
10000210 - 财政年份:2017
- 资助金额:
$ 34.45万 - 项目类别:
Mechanisms underlying resilience to neighborhood disadvantage
抵御邻里劣势的潜在机制
- 批准号:
10212935 - 财政年份:2017
- 资助金额:
$ 34.45万 - 项目类别:
Neurobiological pathways underlying maladaptive behaviors in youth
青少年适应不良行为背后的神经生物学途径
- 批准号:
10409625 - 财政年份:2017
- 资助金额:
$ 34.45万 - 项目类别:
Mechanisms underlying resilience to neighborhood disadvantage (Administrative Supplement)
抵御邻里劣势的潜在机制(行政补充)
- 批准号:
10159683 - 财政年份:2017
- 资助金额:
$ 34.45万 - 项目类别:
From neighborhood disadvantage to antisocial behavior: Neurobiological pathways
从邻里劣势到反社会行为:神经生物学途径
- 批准号:
10015409 - 财政年份:2017
- 资助金额:
$ 34.45万 - 项目类别:
Neurobiological pathways underlying maladaptive behaviors in youth
青少年适应不良行为背后的神经生物学途径
- 批准号:
10158502 - 财政年份:2017
- 资助金额:
$ 34.45万 - 项目类别:
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