Identifying injurious Thoughts and Behaviors in Childhood: A Mixed-Methods Investigation

识别童年时期的有害思想和行为：混合方法调查

• 批准号: 10599521
• 负责人: Margaret Ann Sheridan
• 金额: $ 46.39万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10599521
• 关键词: Address; Adolescence; Adult; Affect; Age; Animals; Behavior; Behavior assessment; Behavioral; Belief; Black race; Brain; Cessation of life; Child; Child Development; Childhood; Cognitive; Communication; Comprehension; Data; Development; Dimensions; Electroencephalography; Enrollment; Evaluation; Exposure to; Family; Feeling suicidal; Foundations; Fright; Functional Magnetic Resonance Imaging; Future; Goals; Home; Home visitation; Human; Iatrogenesis; Interpersonal Violence; Intervention; Interview; Investigation; Learning; Link; Magnetic Resonance Imaging; Measures; Mental disorders; Mentored Research Scientist Development Award; Methods; Modeling; National Institute of Mental Health; Neurobiology; Neurosciences; Outcome; Parents; Pathway interactions; Patient Self-Report; Perception; Physiological; Positioning Attribute; Prevention; Process; Psyche structure; Psychopathology; Recurrence; Reporting; Research; Risk; Risk Behaviors; Risk Factors; Sampling; Self Assessment; Sexual abuse; Strategic Planning; Stress; Structure; Suicide; Suicide attempt; Support System; System; Telephone; Testing; Thinking; Violence; Work; Youth; acceptability and feasibility; adverse childhood events; aged; cognitive control; deprivation; early childhood; early life adversity; experience; follow up assessment; follow-up; member; middle childhood; neglect; neural network; neurobiological mechanism; neurodevelopment; neuroimaging; non-suicidal self injury; novel; parent grant; parent project; physical abuse; preadolescence; recruit; relating to nervous system; resilience; response; social; suicidal morbidity; suicidal risk; violence exposure

Project Summary/Abstract Early adversity profoundly affects diverse aspects of child development, including brain development, physiological reactivity to stress, and long-term risk for mental illness. Most models of these effects focus on the number rather than character of adverse childhood experiences. The current proposal tests a novel conceptual model focused on the type of exposure, which differentiates two primary dimensions of experience underlying multiple forms of adversity: deprivation and threat. Deprivation involves a lack of enriching and species expectant cognitive and social inputs (e.g., neglect). Threat involves actual or perceived danger to the physical integrity of the child (e.g., exposure to violence). Here we test the hypothesis that deprivation and threat increase risk for psychopathology through separable neurobiological pathways. We identify these pathways using basic animal and human neuroscience and present them as compliments to existing models. The proposed project will examine the impact of deprivation and threat on the development of neural networks in Cognitive Control Systems and Negative Valance Systems. We predict that early deprivation exposure results in reduced cognitive control, and disruptions in the neural systems supporting cognitive control. Early threat exposure, in contrast, results in disrupted fear learning and alterations in fear circuitry. The current proposal extends our previous work to include longitudinal prediction of psychopathology during middle childhood and in depth evaluation of the proposed neurodevelopmental mechanisms. It is widely hypothesized that adversity primarily influences neural development during early childhood, yet these associations are most often studied in adolescence and adulthood. Here we propose investigating early adversity exposure in young children aged 4-7 years when these systems are undergoing peak development. To assess deprivation and threat in young children we will use in-depth home assessments including observational and parent-report measures. All children will complete structural MRI and functional neuroimaging using EEG and fMRI. The PI has extensive experience collecting such measures from children in this age range and this work follows directly from her recently completed K01 award. Understanding neurodevelopmental processes linking adversity to psychopathology will open up new pathways to prevention and intervention. The proposed research would directly address Objectives 1 and 2 of the NIMH strategic plan.

项目总结/文摘

项目成果

Classifying Young Children with Attention-Deficit/Hyperactivity Disorder Based on Child, Parent, and Family Characteristics: A Cross-Validation Study.

• DOI: 10.3390/ijerph19159195
• 发表时间: 2022-07-27
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Law, Evelyn;Sideridis, Georgios;Alkhadim, Ghadah;Snyder, Jenna;Sheridan, Margaret
• 通讯作者: Sheridan, Margaret

Building an ecological momentary assessment smartphone app for 4- to 10-year-old children: A pilot study.

• DOI: 10.1371/journal.pone.0290148
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7