Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene, sulfolane and MWCNT in laboratory animals

该项目的目标是支持转化毒理学(DTT)危险识别活动，旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及在大鼠和小鼠身上进行3种不同测试剂的毒性和致癌性研究：α-蒎烯(全身吸入暴露)、环丁硫醚(饮用水暴露)或MWCNT(全身吸入暴露)。α-蒎烯存在于松节油、调味品和香水中。人类可能通过呼吸空气、使用个人护理和清洁产品以及在木材加工和建筑活动中接触到空气。环丁硫醚是一种饮用水污染物，在阿拉斯加州特别令人担忧。MWCNT是一种纳米材料，用于生产许多电子设备。这些研究的数据将用于就这些测试品对大鼠和小鼠的潜在毒性和致癌性制定合理的科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。此外，市民亦可充分了解因接触这些测试试剂而引致的风险因素。 关键词：毒性、致癌性、吸入、饮用水、肺、α-蒎烯、多壁碳纳米管、纳米、环丁硫烷

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies in rats and mice to 3 different test agents: alpha pinene (exposure by whole-body inhalation), sulfolane (exposure in drinking water) or MWCNT (exposure by whole body inhalation). Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed via the air they breathe, through use of personal care and cleaning products as well as in lumber processing and building activities. Sulfolane is a drinking water contaminant, of particular concern in the state of Alaska. MWCNT are a nanomaterial used in the production of a number of electronic devices. The data from these studies will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of these test articles in rats and mice and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to these test agents. Keywords: toxicity, carcinogenicity, inhalation, drinking water, lung, alpha-pinene, MWCNT, nano, sulfolane