Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene, sulfolane and MWCNT in laboratory animals

本项目的目标是为转化毒理学司（DTT）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及在大鼠和小鼠中进行3种不同试验剂的毒性和致癌性研究：α-蒎烯（全身吸入接触）、环丁砜（饮用水接触）或多壁碳纳米管（全身吸入接触）。α-蒎烯存在于松节油、调味品和香水中。人类可能通过呼吸的空气、使用个人护理和清洁产品以及木材加工和建筑活动而接触。环丁砜是一种饮用水污染物，在阿拉斯加州特别令人关注。MWCNT是一种用于生产许多电子设备的纳米材料。这些研究的数据将用于制定关于这些供试品在大鼠和小鼠中的潜在毒性和致癌性的合理科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解接触这些测试剂所产生的风险因素。 关键词：毒性，致癌性，吸入，饮用水，肺，α-蒎烯，多壁碳纳米管，纳米，环丁砜

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies in rats and mice to 3 different test agents: alpha pinene (exposure by whole-body inhalation), sulfolane (exposure in drinking water) or MWCNT (exposure by whole body inhalation). Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed via the air they breathe, through use of personal care and cleaning products as well as in lumber processing and building activities. Sulfolane is a drinking water contaminant, of particular concern in the state of Alaska. MWCNT are a nanomaterial used in the production of a number of electronic devices. The data from these studies will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of these test articles in rats and mice and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to these test agents. Keywords: toxicity, carcinogenicity, inhalation, drinking water, lung, alpha-pinene, MWCNT, nano, sulfolane