Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene, sulfolane and MWCNT in laboratory animals

该项目的目标是为转化毒理学司（DTT）的危险识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。该项目涉及对大鼠和小鼠进行三种不同试验剂的毒性和致癌性研究：α -蒎烯（全身吸入）、亚砜（饮用水中）或MWCNT（全身吸入）。-蒎烯存在于松节油和香料中。人类可能通过呼吸的空气、使用个人护理和清洁产品以及木材加工和建筑活动接触到这种物质。环己烷是一种饮用水污染物，在阿拉斯加州尤其令人担忧。纳米碳纳米管是一种用于生产许多电子器件的纳米材料。这些研究的数据将用于对这些试验品在大鼠和小鼠身上的潜在毒性和致癌性得出合理的科学结论，并最终支持数字地面电视的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解暴露于这些试验剂所产生的风险因素。

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies in rats and mice to 3 different test agents: alpha pinene (exposure by whole-body inhalation), sulfolane (exposure in drinking water) or MWCNT (exposure by whole body inhalation). Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed via the air they breathe, through use of personal care and cleaning products as well as in lumber processing and building activities. Sulfolane is a drinking water contaminant, of particular concern in the state of Alaska. MWCNT are a nanomaterial used in the production of a number of electronic devices. The data from these studies will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of these test articles in rats and mice and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to these test agents. Keywords: toxicity, carcinogenicity, inhalation, drinking water, lung, alpha-pinene, MWCNT, nano, sulfolane