Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer's disease and related dementias

现有三项阿尔茨海默病和相关痴呆症队列研究中运动和认知障碍的神经病理学基础

• 批准号: 9425480
• 负责人: Thomas J Montine
• 金额: $ 388.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9425480
• 关键词: Abbreviations; Age; Age of Onset; Aged, 80 and over; Aging; Alzheimer' s Disease; Apolipoprotein E; Asia; Autopsy; Brain; Cerebrovascular Disorders; Cerebrovascular Trauma; Cessation of life; Cognition; Cohort Studies; Dementia; Development; Disease; Elderly; Equilibrium; Ethnic Origin; Forced expiratory volume function; Frequencies; Funding; Future; Gait; Gait speed; Gender; Glial Fibrillary Acidic Protein; Hand Strength; Impaired cognition; Impairment; Individual; Late Onset Alzheimer Disease; Lesion; Lewy Bodies; Life; Link; Location; Longitudinal Studies; Measurement; Measures; Motor; National Institute on Aging; Neurodegenerative Disorders; Neurofibrillary Tangles; Neuropsychological Tests; Participant; Pattern; Persons; Predictive Factor; Prevention strategy; Process; Protocols documentation; Regional Disease; Registries; Research; Research Personnel; Resources; Risk; Risk Factors; Senile Plaques; Severities; Substantia nigra structure; Syndrome; Testing; Time; Woman; Work; aging brain; analytical tool; base; cognitive ability; cognitive development; cognitive function; cohort; diagnostic accuracy; hippocampal sclerosis; instrument; locus ceruleus structure; men; mental state; motor impairment; neural circuit; paired helical filament; population based; protein TDP-43; screening; sex

Abstract/Summary The proposed work will investigate the pathogeneses of late life cognitive and motor impairments attributed to Alzheimer's disease, closely allied cerebrovascular and neurodegenerative diseases, brain aging, and their common patterns of co-occurrence in three existing cohorts: the Honolulu-Asia Aging Study, the Nun Study, and the 90+ Study. Our focus will be on relationships among objective, longitudinal measures of motor function and cognition–with the last obtained proximate to death–and a defined set of neuropathologic substrates identified at autopsy. Parallel and merged analyses will be carried out using existing resources provided from these three large population-based longitudinal studies composed of participants with distinctly different gender, age, and ethnicity. We will leverage these substantial existing resources to test the hypothesis that cognitive and motor impairments that occur with advancing age are syndromic and derive from a partially overlapping mix of diseases that vary among individuals in part by age, sex, and ethnicity, and that can be identified best at the current time by their neuropathologic features. This will allow the identification of common patterns for the singular, concurrent, or sequential development of cognitive and/or motor impairments in persons with and without dementia. The informational wealth of these three studies (all established and supported with NIA funding) will be further expanded and available to teams of collaborating researchers for continuing analyses.

抽象/总结