Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer's disease and related dementias
Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer's disease and related dementias
批准号:
9425480
负责人:
Thomas J Montine
金额:
$388.02万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-15 至 2022-06-30
关键词:
AbbreviationsAgeAge of OnsetAged, 80 and overAgingAlzheimer&aposs DiseaseApolipoprotein EAsiaAutopsyBrainCerebrovascular DisordersCerebrovascular TraumaCessation of lifeCognitionCohort StudiesDementiaDevelopmentDiseaseElderlyEquilibriumEthnic OriginForced expiratory volume functionFrequenciesFundingFutureGaitGait speedGenderGlial Fibrillary Acidic ProteinHand StrengthImpaired cognitionImpairmentIndividualLate Onset Alzheimer DiseaseLesionLewy BodiesLifeLinkLocationLongitudinal StudiesMeasurementMeasuresMotorNational Institute on AgingNeurodegenerative DisordersNeurofibrillary TanglesNeuropsychological TestsParticipantPatternPersonsPredictive FactorPrevention strategyProcessProtocols documentationRegional DiseaseRegistriesResearchResearch PersonnelResourcesRiskRisk FactorsSenile PlaquesSeveritiesSubstantia nigra structureSyndromeTestingTimeWomanWorkaging brainanalytical toolbasecognitive abilitycognitive developmentcognitive functioncohortdiagnostic accuracyhippocampal sclerosisinstrumentlocus ceruleus structuremenmental statemotor impairmentneural circuitpaired helical filamentpopulation basedprotein TDP-43screeningsex
中文摘要
抽象/总结
英文摘要
Abstract/Summary
The proposed work will investigate the pathogeneses of late life cognitive and motor impairments attributed to
Alzheimer's disease, closely allied cerebrovascular and neurodegenerative diseases, brain aging, and their
common patterns of co-occurrence in three existing cohorts: the Honolulu-Asia Aging Study, the Nun Study,
and the 90+ Study. Our focus will be on relationships among objective, longitudinal measures of motor function
and cognition–with the last obtained proximate to death–and a defined set of neuropathologic substrates
identified at autopsy. Parallel and merged analyses will be carried out using existing resources provided from
these three large population-based longitudinal studies composed of participants with distinctly different
gender, age, and ethnicity. We will leverage these substantial existing resources to test the hypothesis that
cognitive and motor impairments that occur with advancing age are syndromic and derive from a partially
overlapping mix of diseases that vary among individuals in part by age, sex, and ethnicity, and that can be
identified best at the current time by their neuropathologic features. This will allow the identification of common
patterns for the singular, concurrent, or sequential development of cognitive and/or motor impairments in
persons with and without dementia. The informational wealth of these three studies (all established and
supported with NIA funding) will be further expanded and available to teams of collaborating researchers for
continuing analyses.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Neuropath Core
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批准号:10262851
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项目类别:
-
资助金额:$37.48万
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财政年份:2021
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负责人:Thomas J Montine
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依托单位:
Neuropath Core
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批准号:10663237
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项目类别:
-
资助金额:$37.97万
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财政年份:2021
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负责人:Thomas J Montine
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依托单位:
Neuropath Core
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批准号:10461184
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项目类别:
-
资助金额:$38.19万
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财政年份:2021
-
负责人:Thomas J Montine
-
依托单位:
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
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批准号:10359193
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项目类别:
-
资助金额:$46.18万
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财政年份:2020
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负责人:Thomas J Montine
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依托单位:
Neuropathology Core
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批准号:10409745
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项目类别:
-
资助金额:$36.56万
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财政年份:2020
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负责人:Thomas J Montine
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依托单位:
Neuropathology Core
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批准号:10176345
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项目类别:
-
资助金额:$40.89万
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财政年份:2020
-
负责人:Thomas J Montine
-
依托单位:
Project 2: Particle and brain mapping of CSF proteins using elemental reporters with mass spectrometry
-
批准号:10573262
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项目类别:
-
资助金额:$48.89万
-
财政年份:2020
-
负责人:Thomas J Montine
-
依托单位:
Neuropathology Core
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批准号:10385833
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项目类别:
-
资助金额:$28.75万
-
财政年份:2019
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负责人:Thomas J Montine
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依托单位:
Neuropathology Core
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批准号:10601059
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项目类别:
-
资助金额:$27.05万
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财政年份:2019
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负责人:Thomas J Montine
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依托单位:
Clinical Genome Resource (ClinGen)
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批准号:9769097
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项目类别:
-
资助金额:$299.07万
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财政年份:2017
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负责人:Thomas J Montine
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依托单位:
Clinical Genome Resource (ClinGen)
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批准号:9930778
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项目类别:
-
资助金额:$68.17万
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财政年份:2017
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负责人:Thomas J Montine
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依托单位:
Core D: Neuropathology Core
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批准号:9095181
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项目类别:
-
资助金额:$16.48万
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财政年份:2016
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负责人:Thomas J Montine
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依托单位:
Neuropathologic research on dementia using Nun Study and HAAS data
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批准号:8526141
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项目类别:
-
资助金额:$62.77万
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财政年份:2013
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负责人:Thomas J Montine
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依托单位:
Neuropathologic research on dementia using Nun Study and HAAS data
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批准号:8900504
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项目类别:
-
资助金额:$7.98万
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财政年份:2013
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负责人:Thomas J Montine
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依托单位:
Udall Center Director's meeting poster award
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批准号:8768746
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项目类别:
-
资助金额:$0.25万
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财政年份:2013
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负责人:Thomas J Montine
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依托单位:
Pacific Northwest Udall Center
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批准号:7897675
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项目类别:
-
资助金额:$165.63万
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财政年份:2009
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负责人:Thomas J Montine
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依托单位:
White matter damage in age-related cognitive decline
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批准号:8919486
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项目类别:
-
资助金额:$4.98万
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财政年份:2009
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负责人:Thomas J Montine
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依托单位:
Administrative Core
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批准号:9015039
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项目类别:
-
资助金额:$15.31万
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财政年份:2009
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负责人:Thomas J Montine
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依托单位:
White matter damage in age-related cognitive decline
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批准号:8457826
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项目类别:
-
资助金额:$70.15万
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财政年份:2009
-
负责人:Thomas J Montine
-
依托单位:
White matter damage in age-related cognitive decline
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批准号:7578785
-
项目类别:
-
资助金额:$127.77万
-
财政年份:2009
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负责人:Thomas J Montine
-
依托单位:
国内基金
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