2023 Mammalian DNA Repair GRC & GRS

项目摘要/摘要 这次为期5天的GRC和为期2天的GRS会议的重点是基因组不稳定性及其 对人类疾病和治疗的影响。暴露环境和内源性DNA来源 每个细胞的损伤每年会产生数千到100多万个损伤和对基因组的化学修饰 天。DNA损伤的常见环境来源包括阳光、辐射、醛和燃烧 副产物，而内源来源包括氧代谢、代谢物、烷基化和调节失调 DNA复制、转录和有丝分裂。在正常细胞中，大量的DNA修复和DNA损伤 反应机制成功地维持了基因组的稳定性。然而，这些中的缺陷 机制可导致一系列疾病，从罕见的发育和早衰综合征到 常见的癌症。这一哺乳动物DNA修复戈登研究会议(GRC)和相关的戈登 研究研讨会(GRS)将汇集不同的研究人员，研究保护 抗DNA损伤的基因组，以及当这些途径失效时对人类健康的后果。 此外，本次会议还将促进关于如何抑制DNA损伤反应和修复的讨论 机制，或利用这些机制中的功能障碍，来选择性地靶向肿瘤更有效 毒性更小的方式。目标是：1)让所有级别的研究人员(教职员工、来自 行业、博士后研究员和研究生)在这一快速发展中走向新的前沿和创新的方法 不断进步的研究领域。2)为青年科学家提供建立网络和练习演示的机会 他们的研究。3)创造包容和严谨的氛围，鼓励科学交流 可能促进合作或刺激新创新的想法。4)提供正式和非正式的职业生涯 发展机遇。我们将通过召集不同的演讲者和海报来实现这些目标 主讲人。GRC中44%的受邀演讲者是女性，我们预计GRC中约50%的演讲者是女性 演讲者为女性实习生。与关于类似主题的会议相比，这一GRC/GRS值得注意 提交的未发表的研究，以及会议期间广泛的非正式讨论时间， 用餐和空闲时间。

Project Abstract/Summary This 5-day GRC and 2-day GRS conference is focused on the research of genomic instability and its implications in human diseases and therapies. Exposures environmental and endogenous source of DNA damage produce thousands to over a million lesions and chemical modifications to the genome per cell every day. Common environmental sources of DNA damage include sunlight, radiation, aldehydes, and combustion byproducts, while endogenous sources include oxygen metabolism, metabolites, alkylation and dysregulation of DNA replication, transcription and mitosis. In normal cells, a multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genomic stability. However, defects in these mechanisms can result in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will bring together diverse researchers studying the mechanisms that protect the genome against DNA damage, and the consequences for human health when these pathways fail. Additionally, this conference will promote discussions on how to inhibit DNA damage response and repair mechanisms, or leverage dysfunction in these mechanisms, to selectively target tumors in a more efficacious and less toxic manner. The objectives are: 1) To expose researchers at all levels (faculty, researchers from industry, postdoctoral fellows, and graduate students) to new frontiers and innovative methods in this rapidly progressing research field. 2) To provide opportunities for young scientists to network and practice presenting their research. 3) To generate an atmosphere of inclusion and rigor that encourages the exchange of scientific ideas that may foster collaborations or spur new innovation. 4) To provide formal and informal career development opportunities. We will achieve these objectives by assembling diverse speakers and poster presenters. 44% of the invited speakers in the GRC are women and we expect approximately 50% of the GRS speakers be female trainees. This GRC/GRS is notable compared to meetings on similar topics for the amount of unpublished research that is presented, as well as the extensive informal discussion time during sessions, meals, and free time.