2023 Mammalian DNA Repair GRC & GRS

2023 哺乳动物 DNA 修复 GRC

• 批准号: 10607587
• 负责人: Patricia L Opresko
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-02 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10607587
• 关键词: Address; Age; Aging; Aldehydes; Alkylation; Atmosphere; CRISPR/Cas technology; California; Cell physiology; Cells; Chemicals; Clinical; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communities; DNA; DNA Damage; DNA Repair; DNA Repair Pathway; DNA biosynthesis; Defect; Degenerative Disorder; Development; Disease; Eating; Environmental Exposure; Exposure to; Faculty; Female; Fostering; Functional disorder; Gender; Genetic Transcription; Genome; Genome Stability; Genome engineering; Genomic Instability; Health; Human; Human Genome; Immune signaling; Immunotherapy; Industry; Intervention; Knowledge; Leadership; Learning; Lesion; Maintenance; Malignant Neoplasms; Mediating; Metabolism; Methods; Mitosis; Modeling; Modification; Neurodegenerative Disorders; Normal Cell; Oral; Oxygen; Participant; Pathway interactions; Postdoctoral Fellow; Premature aging syndrome; Radiation; Research; Research Personnel; Science; Scientist; Series; Source; Sunlight; Time; Woman; career development; combustion product; experience; frontier; graduate student; human disease; inhibitor; innovation; interest; meetings; member; posters; programs; repaired; response; scientific atmosphere; social; symposium; targeted treatment; tumor

Project Abstract/Summary This 5-day GRC and 2-day GRS conference is focused on the research of genomic instability and its implications in human diseases and therapies. Exposures environmental and endogenous source of DNA damage produce thousands to over a million lesions and chemical modifications to the genome per cell every day. Common environmental sources of DNA damage include sunlight, radiation, aldehydes, and combustion byproducts, while endogenous sources include oxygen metabolism, metabolites, alkylation and dysregulation of DNA replication, transcription and mitosis. In normal cells, a multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genomic stability. However, defects in these mechanisms can result in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will bring together diverse researchers studying the mechanisms that protect the genome against DNA damage, and the consequences for human health when these pathways fail. Additionally, this conference will promote discussions on how to inhibit DNA damage response and repair mechanisms, or leverage dysfunction in these mechanisms, to selectively target tumors in a more efficacious and less toxic manner. The objectives are: 1) To expose researchers at all levels (faculty, researchers from industry, postdoctoral fellows, and graduate students) to new frontiers and innovative methods in this rapidly progressing research field. 2) To provide opportunities for young scientists to network and practice presenting their research. 3) To generate an atmosphere of inclusion and rigor that encourages the exchange of scientific ideas that may foster collaborations or spur new innovation. 4) To provide formal and informal career development opportunities. We will achieve these objectives by assembling diverse speakers and poster presenters. 44% of the invited speakers in the GRC are women and we expect approximately 50% of the GRS speakers be female trainees. This GRC/GRS is notable compared to meetings on similar topics for the amount of unpublished research that is presented, as well as the extensive informal discussion time during sessions, meals, and free time.

项目摘要/摘要 这次为期5天的GRC和2天的GRS会议侧重于基因组不稳定性及其其ITS的研究 人类疾病和疗法的影响。暴露于DNA的环境和内源性来源 损害会导致数千至100万个病变和化学修饰每个细胞的基因组 天。 DNA损伤的常见环境来源包括阳光，辐射，醛和燃烧 副产品，虽然内源性来源包括氧代谢，代谢产物，烷基化和失调 DNA复制，转录和有丝分裂。在正常细胞中，多种DNA修复和DNA损伤 响应机制成功运行以维持基因组稳定性。但是，这些缺陷 机制可能导致疾病，从罕见的发育和过早衰老综合症到 常见的癌症。这次哺乳动物DNA维修戈登研究会议（GRC）和相关的戈登 研究研讨会（GRS）将汇集各种研究人员，研究保护该机制的机制 针对DNA损伤的基因组，以及这些途径失败时对人类健康的后果。 此外，该会议将促进有关如何抑制DNA损伤响应和修复的讨论 在这些机制中的机制或利用功能障碍，可以选择性地靶向更有效的肿瘤 和毒性较少。目标是：1）揭露各级研究人员（教职员工，来自 行业，博士后研究员和研究生）在这种迅速的新领域和创新方法中 进步研究领域。 2）为年轻科学家提供网络和实践展示的机会 他们的研究。 3）产生一种包容性和严谨的气氛，以鼓励科学交换 可能促进合作或刺激新创新的想法。 4）提供正式和非正式的职业 发展机会。我们将通过组装不同的演讲者和海报来实现这些目标 主持人。 GRC中有44％的受邀演讲者是女性，我们预计大约有50％的GRS 演讲者是女学员。与该金额类似主题的会议相比，此GRC/GRS值得注意 提出的未发表的研究以及会议期间的广泛非正式讨论时间 用餐和空闲时间。