2023 Mammalian DNA Repair GRC & GRS

项目摘要/摘要 这个为期5天的GRC和2天的GRS会议的重点是研究基因组不稳定性及其 对人类疾病和治疗的影响。暴露于环境和内源性DNA来源 损伤产生数千至超过一百万个损伤和化学修饰的基因组每个细胞， 天DNA损伤的常见环境来源包括阳光、辐射、醛类和燃烧 副产物，而内源性来源包括氧代谢，代谢物，烷基化和失调 DNA复制、转录和有丝分裂的过程。在正常细胞中，大量的DNA修复和DNA损伤 反应机制成功地维持了基因组的稳定性。然而，这些缺陷 这些机制可能导致从罕见的发育和过早衰老综合征到 常见的癌症这次哺乳动物DNA修复戈登研究会议（GRC）和相关的戈登 研究研讨会（GRS）将汇集不同的研究人员研究保护机制， 基因组对抗DNA损伤，以及当这些途径失败时对人类健康的后果。 此外，本次会议将促进关于如何抑制DNA损伤反应和修复的讨论 机制，或利用这些机制中的功能障碍，以更有效的方式选择性靶向肿瘤。 更少的毒性。目标是：1）使各级研究人员（教师，研究人员， 产业，博士后研究员和研究生）的新的前沿和创新的方法，在这迅速 研究领域的进步。2)为青年科学家提供建立网络和实践演示的机会 他们的研究。3)创造一种包容和严谨的氛围，鼓励科学交流， 可能促进合作或刺激新创新的想法。4)提供正式和非正式的职业 发展机遇。我们将通过召集不同的演讲者和海报来实现这些目标 主持人GRC中44%的受邀演讲者是女性，我们预计GRS中约有50%是女性 演讲者是女性学员。与关于类似主题的会议相比， 未发表的研究报告，以及会议期间广泛的非正式讨论时间， 吃饭和自由时间。

Project Abstract/Summary This 5-day GRC and 2-day GRS conference is focused on the research of genomic instability and its implications in human diseases and therapies. Exposures environmental and endogenous source of DNA damage produce thousands to over a million lesions and chemical modifications to the genome per cell every day. Common environmental sources of DNA damage include sunlight, radiation, aldehydes, and combustion byproducts, while endogenous sources include oxygen metabolism, metabolites, alkylation and dysregulation of DNA replication, transcription and mitosis. In normal cells, a multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genomic stability. However, defects in these mechanisms can result in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will bring together diverse researchers studying the mechanisms that protect the genome against DNA damage, and the consequences for human health when these pathways fail. Additionally, this conference will promote discussions on how to inhibit DNA damage response and repair mechanisms, or leverage dysfunction in these mechanisms, to selectively target tumors in a more efficacious and less toxic manner. The objectives are: 1) To expose researchers at all levels (faculty, researchers from industry, postdoctoral fellows, and graduate students) to new frontiers and innovative methods in this rapidly progressing research field. 2) To provide opportunities for young scientists to network and practice presenting their research. 3) To generate an atmosphere of inclusion and rigor that encourages the exchange of scientific ideas that may foster collaborations or spur new innovation. 4) To provide formal and informal career development opportunities. We will achieve these objectives by assembling diverse speakers and poster presenters. 44% of the invited speakers in the GRC are women and we expect approximately 50% of the GRS speakers be female trainees. This GRC/GRS is notable compared to meetings on similar topics for the amount of unpublished research that is presented, as well as the extensive informal discussion time during sessions, meals, and free time.