2023 Physical Science of Cancer GRC/GRS

2023年癌症物理科学GRC/GRS

• 批准号: 10609179
• 负责人: Jennifer M Munson
• 金额: $ 1.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-20 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10609179
• 关键词: Address; Big Data; Biological; Biology; Biomedical Engineering; Biophysics; Cancer Biology; Cancer Science; Cancerous; Cells; Chemistry; Collaborations; Communication; Complex; Computational Science; Data; Data Science; Dedications; Development; Diagnostic; Discipline; Disease; Engineering; Environment; Exposure to; Fostering; Foundations; Funding Agency; Future; Genetic; Goals; Hearing; Hour; Human body; Individual; Interdisciplinary Study; International; Journals; Malignant Neoplasms; Mathematics; Medicine; Mentorship; Methodist Church; Methodology; Methods; Minnesota; Molecular; Oncology; Oral; Organ; Participant; Patients; Physics; Postdoctoral Fellow; Productivity; Recurrent disease; Research; Research Personnel; Role; Scientist; Shapes; Signal Transduction; Site; System; Systemic disease; Technology; Texas; Time; Tissues; Training; Translating; Virginia; Voice; Wisconsin; anticancer research; cancer type; career; clinical translation; design; expectation; graduate student; individual patient; innovation; interdisciplinary approach; mathematical model; mechanical properties; meetings; multidisciplinary; next generation; novel; personalized diagnostics; personalized medicine; physical property; physical science; posters; programs; role model; social; success; symposium; synergism; tool; translational approach; translational potential; tumor; tumor initiation; tumor microenvironment; tumor progression; unpublished works

Project Summary/Abstract Despite the wide variety of genetic and molecular information available to characterize a patient's tumor, a precise individual prediction of cancer progression is only possible to a limited extend. This suggests that vital data about tumor progression are missing such as the physical and mechanical properties of cells and surrounding tissue. Considering the complexity of cancer as a systemic disease recently high expectations have been raised that an interdisciplinary approach by combining biology, chemistry, mathematics, engineering, big data, and physics with biomedicine will lead to convergent oncology. Emergent phenomena which are not directly triggered by a specific molecule can be only understood by a convergent approach. Partial support is requested for the 3rd iteration of the "Physical Science of Cancer" Gordon Research Conference (GRC) to be held from Feb.5-10, 2023, and the 2nd iteration of the “Physical Science of Cancer” Gordon Research Seminar (GRS) to be held from Feb.4-5, 2023. These meetings will be held at the GRC-selected conference hotel (The Grand Galvez) in Galveston, Texas. The conference is promised to provide a forum for the presentation and discussion of recent advances and new ideas on multidisciplinary approaches and their success in understanding fundamental cancer progression as well as in developing potential translational perspectives. The long-term goal of this GRC is to facilitate the development and use of approaches to extend the range of cancer targets that can be tackled successfully. These will be achieved with the following aims: (1) Review advances and identify challenges in quantitative approaches in cancer. (2) Train the next generation of scientists to quantitatively investigate the underlying physical mechanisms that drive cancer (GRS) and facilitate diversity participation. (3) Foster new collaborations with emphasis on using quantitative approaches to address challenges in cancer. Session topics have been selected on the basis of their potential impact on key scientific challenges of the field and for their strength in transdisciplinary approaches. A focus on giving diverse voices, in background, stage of career, and discipline will be central to our program. We will introduce inclusive mentorship as a primary focus in order to better train and foster the next generation of multi-disciplinary cancer researchers. Poster sessions will provide ample opportunities for engagement between investigators at all levels. We anticipate that scientific interactions during this conference will impact cancer research in significant ways and result in establishing productive multi-disciplinary research collaborations. Collectively this conference will highlight the significant progress in the last four years, and catalyze the development of new concepts and synergies that will aim to shape the future of Physical Sciences in Cancer and allow us to holistically study phenomena. Ultimately, the dynamic interactions among these systems shape the forces that drive tumor initiation, progression, metastatic spread, and disease recurrence. The application of physics and mathematics foundations to the molecular, cellular, tissue, and organ level basis of cancer has revealed fundamental changes during disease that are reflected across cancer types and stages. In this conference we will hear from experts applying physical sciences to cancer to study disease phenomena across scales and systems.

项目总结/摘要 尽管有各种各样的遗传和分子信息可用于表征患者的肿瘤， 癌症进展的精确个体预测仅在有限程度上是可能的。这表明， 缺少关于肿瘤进展的数据，例如细胞的物理和机械特性， 周围组织考虑到癌症作为一种系统性疾病的复杂性， 已经提出了一个跨学科的方法，通过结合生物学，化学，数学，工程学， 大数据和物理学与生物医学将导致融合肿瘤学。非自然现象 由特定分子直接触发的，只能通过一种趋同的方法来理解。部分支持是 要求第三次迭代的“癌症物理科学”戈登研究会议（GRC）将 2023年2月5日至10日举行，第二届“癌症的物理科学”戈登研究研讨会 (GRS)将于2023年2月4日至5日举行。这些会议将在GRC选定的会议酒店（ 德克萨斯州加尔维斯顿的Grand Galvez）。会议承诺为介绍提供一个论坛， 讨论多学科方法的最新进展和新想法及其在 了解基本的癌症进展以及发展潜在的转化前景。 本全球资源中心的长期目标是促进各种方法的发展和使用， 可以成功解决的癌症目标。将通过以下目标实现这些目标： (1)回顾癌症定量方法的进展并确定挑战。 (2)培养下一代科学家定量研究潜在的物理机制 推动癌症（GRS）和促进多样性参与。 (3)促进新的合作，重点是使用量化方法应对以下方面的挑战： 癌 会议主题是根据其对该领域关键科学挑战的潜在影响而选择的 以及他们在跨学科方法上的优势。注重在背景和舞台上发出不同的声音 职业和纪律将是我们计划的核心。我们将引入包容性导师制作为主要的 专注于更好地培养和培养下一代多学科癌症研究人员。海报 会议将为各级调查人员之间的接触提供充分的机会。我们预计 本次会议期间的科学互动将对癌症研究产生重大影响，并导致 建立富有成效的多学科研究合作。 总的来说，这次会议将突出过去四年来取得的重大进展，并促进 发展新的概念和协同作用，旨在塑造癌症物理科学的未来 让我们能够从整体上研究现象。最终，这些系统之间的动态相互作用形成了 推动肿瘤发生、发展、转移扩散和疾病复发的力量。应用 癌症的分子、细胞、组织和器官水平基础的物理和数学基础， 揭示了疾病期间的根本变化，这些变化反映在癌症类型和阶段中。在这 会议上，我们将听取专家们将物理科学应用于癌症研究疾病现象， 规模和系统。