TRD 2: Metabolic Markers
TRD 2: Metabolic Markers
批准号:
10614610
负责人:
Richard Anthony Edward Edden
金额:
$19.69万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-07-01 至 2026-04-30
关键词:
AffectAnatomyAntioxidantsBindingBiochemicalBiochemistryBiological MarkersBrainBrain ChemistryBrain imagingChemicalsCollaborationsCommunitiesCouplingDataData AnalysesData SetDecision MakingDetectionDevelopmentDiagnosisDiffusion Magnetic Resonance ImagingDiseaseFingerprintFunctional Magnetic Resonance ImagingGlutamatesGlutathioneImageImmobilizationLabelLeadLibrariesMachine LearningMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMagnetismMeasurementMeasuresMetabolicMetabolic MarkerMethodsModelingMolecularMonitorN-acetylaspartylglutamateNeuromodulatorNeurotransmittersOncologyPhosphocreatinePhysiologic pulsePhysiologicalPreparationPrincipal InvestigatorPropertyProteinsProtonsRadiology SpecialtyRelaxationReproducibilityResearch PersonnelResolutionResourcesScheduleSchemeServicesShapesSignal TransductionSpecificitySystemTechniquesTestingTrainingValidationWateramplification detectionbase editingbrain abnormalitiesbrain metabolismdeep learningdesigndetection sensitivitygamma-Aminobutyric Acidimprovedinnovationinterestmacromoleculemetabolic imagingnervous system disorderopen sourceprofessorresponsesmall moleculespectroscopic imagingstatisticssynergismtool
中文摘要
TRD2:代谢标记物
首席研究员:理查德·埃登,放射学教授
共同调查人员:Peter van Zijl,Peter Barker,Georg Oeltzschner,Jiadi Xu,Hye-Young Heo,
尼尔巴伊·亚达夫。
这项研究将利用磁共振波谱技术开发大脑新陈代谢的生物标记物。
(MRS)和化学交换饱和转移成像(CEST-MRI)。我们将开发新的
编辑多路复用编辑MRS的计划,允许同时解决多个问题
合作项目感兴趣的低浓度代谢物,包括神经递质
如GABA,抗氧化剂如谷胱甘肽,以及神经调节剂,如N-
乙酰天冬氨酸谷氨酸。我们将把这些方法与光谱成像读数结合起来。
并发展了多光谱线性组合建模方法进行定量化。编辑过的
CEST方法,调整采集参数以提高检测的特异性,CEST
将开发指纹识别和单次Z-光谱方法。深度学习工具
对于这些数据的分析也将制定,并特别注重整合
方法,以及基于MRSI的光谱分辨率增强和代谢编辑
CEST分析的培训。根据这项TRD开发的获取和分析工具将是
传播到协作项目和服务项目,以在新的
环境,以及更广泛的社区。
英文摘要
TRD 2: Metabolic Markers
Lead Principal investigator: Richard Edden, Professor of Radiology
Co-investigators: Peter van Zijl, Peter Barker, Georg Oeltzschner, Jiadi Xu, Hye-Young Heo,
Nirbhay Yadav.
This TRD will develop biomarkers of brain metabolism, using magnetic resonance spectroscopy
(MRS) and chemical exchange-saturation transfer imaging (CEST-MRI). We will develop new
editing schedules for multiplexed editing MRS, allowing the simultaneous resolution of several
low-concentration metabolites of interest to collaborative projects, including neurotransmitters
such as GABA, antioxidants such as glutathione, and neuromodulators such as N-
acetylaspartylglutamate. We will combine these methods with spectroscopic imaging readouts
and develop multi-spectrum linear combination modeling approached for quantification. Edited
CEST approaches, tuning acquisition parameters to improve specificity of detection, CEST
fingerprinting, and single-shot z-spectrum approaches will be developed. Deep learning tools
for the analysis of these data will also be developed, with a particular focus on the integration
of methods, and spectral resolution enhancement and metabolic editing by MRSI-based
training of CEST analyses. Acquisition and analysis tools developed under this TRD will be
disseminated to collaborative projects and service projects, to establish reproducibility in a new
setting, and to the broader community.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Edited Magnetic Resonance Spectroscopy of the Pediatric Brain
-
批准号:10583752
-
项目类别:
-
资助金额:$73.21万
-
财政年份:2023
-
负责人:Richard Anthony Edward Edden
-
依托单位:
TRD 2: Metabolic Markers
-
批准号:10270099
-
项目类别:
-
资助金额:$17.5万
-
财政年份:2021
-
负责人:Richard Anthony Edward Edden
-
依托单位:
TRD 2: Metabolic Markers
-
批准号:10439904
-
项目类别:
-
资助金额:$19.48万
-
财政年份:2021
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Measuring Altered Glutathione in Children with Autism Spectrum Disorder
-
批准号:10223398
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项目类别:
-
资助金额:$20.34万
-
财政年份:2020
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Measuring Altered Glutathione in Children with Autism Spectrum Disorder
-
批准号:10055287
-
项目类别:
-
资助金额:$25.97万
-
财政年份:2020
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Neurometabolic profile of mild cognitive impairment using multiplexed edited MRS
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批准号:9759752
-
项目类别:
-
资助金额:$20.44万
-
财政年份:2018
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Simultaneous Hadamard Editing of GABA and Glutathione
-
批准号:9286636
-
项目类别:
-
资助金额:$38.14万
-
财政年份:2017
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Simultaneous Hadamard Editing of GABA and Glutathione
-
批准号:10495231
-
项目类别:
-
资助金额:$57.69万
-
财政年份:2017
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Simultaneous Hadamard Editing of GABA and Glutathione
-
批准号:10366442
-
项目类别:
-
资助金额:$61.25万
-
财政年份:2017
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Simultaneous Hadamard Editing of GABA and Glutathione
-
批准号:9896825
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项目类别:
-
资助金额:$36.78万
-
财政年份:2017
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Somatosensory Inhibitory Dysfunction in Autism Spectrum Disorder.
-
批准号:9029614
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项目类别:
-
资助金额:$58.58万
-
财政年份:2016
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal GABA-edited MRS at 3T
-
批准号:8708074
-
项目类别:
-
资助金额:$34.91万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Dysfunction of Sensory Inhibition in Autism
-
批准号:8686958
-
项目类别:
-
资助金额:$20.21万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal Edited MRS at 3T
-
批准号:9752619
-
项目类别:
-
资助金额:$35.49万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal Edited MRS at 3T
-
批准号:9924268
-
项目类别:
-
资助金额:$35.49万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal GABA-edited MRS at 3T
-
批准号:8577507
-
项目类别:
-
资助金额:$38.04万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Dysfunction of Sensory Inhibition in Autism
-
批准号:8511024
-
项目类别:
-
资助金额:$25.81万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal Edited MRS at 3T
-
批准号:10735985
-
项目类别:
-
资助金额:$67.3万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal GABA-edited MRS at 3T
-
批准号:9108382
-
项目类别:
-
资助金额:$35.58万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
Universal Edited MRS at 3T
-
批准号:10152587
-
项目类别:
-
资助金额:$34.78万
-
财政年份:2013
-
负责人:Richard Anthony Edward Edden
-
依托单位:
海外基金