课题基金 / 基金详情

TRD 2: Metabolic Markers

TRD 2: Metabolic Markers
TRD 2:代谢标志物
批准号:
10614610
负责人:
Richard Anthony Edward Edden
金额:
$19.69万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-07-01 至 2026-04-30

项目摘要

项目成果

Richard Anthony Edward Edden的其他基金

相似基金

相关文献

中文摘要
翻译
TRD 2:代谢标志物 首席研究员:Richard Edden,放射学教授 共同研究者:Peter货车Zijl,Peter Barker,Georg Oeltzschner,Jiadi Xu,Hye-Young Heo, 尼尔拜·亚达夫 该TRD将使用磁共振光谱学开发大脑代谢的生物标志物 (MRS)和化学交换饱和转移成像(CEST-MRI)。发展新型 多路编辑MRS的编辑时间表,允许同时解决几个 合作项目感兴趣的低浓度代谢物,包括神经递质 如GABA,抗氧化剂如谷胱甘肽,和神经调节剂如N- 乙酰基谷氨酸我们将联合收割机与光谱成像读数结合起来 并建立了多光谱线性组合模型定量方法。编辑 CEST方法,调整采集参数以提高检测特异性, 将开发指纹识别和单次激发z谱方法。深度学习工具 还将开发这些数据的分析,特别注重整合 的方法,并通过基于MRI的光谱分辨率增强和代谢编辑 CEST分析培训。在本技术建议文件下开发的采集和分析工具将 传播到合作项目和服务项目,以建立一个新的可重复性 #21453;,以及更广泛的社区。
英文摘要
TRD 2: Metabolic Markers Lead Principal investigator: Richard Edden, Professor of Radiology Co-investigators: Peter van Zijl, Peter Barker, Georg Oeltzschner, Jiadi Xu, Hye-Young Heo, Nirbhay Yadav. This TRD will develop biomarkers of brain metabolism, using magnetic resonance spectroscopy (MRS) and chemical exchange-saturation transfer imaging (CEST-MRI). We will develop new editing schedules for multiplexed editing MRS, allowing the simultaneous resolution of several low-concentration metabolites of interest to collaborative projects, including neurotransmitters such as GABA, antioxidants such as glutathione, and neuromodulators such as N- acetylaspartylglutamate. We will combine these methods with spectroscopic imaging readouts and develop multi-spectrum linear combination modeling approached for quantification. Edited CEST approaches, tuning acquisition parameters to improve specificity of detection, CEST fingerprinting, and single-shot z-spectrum approaches will be developed. Deep learning tools for the analysis of these data will also be developed, with a particular focus on the integration of methods, and spectral resolution enhancement and metabolic editing by MRSI-based training of CEST analyses. Acquisition and analysis tools developed under this TRD will be disseminated to collaborative projects and service projects, to establish reproducibility in a new setting, and to the broader community.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Edited Magnetic Resonance Spectroscopy of the Pediatric Brain
  • 批准号:
    10583752
  • 项目类别:
  • 资助金额:
    $73.21万
  • 财政年份:
    2023
  • 负责人:
    Richard Anthony Edward Edden
  • 依托单位:
TRD 2: Metabolic Markers
TRD 2: Metabolic Markers
Measuring Altered Glutathione in Children with Autism Spectrum Disorder
  • 批准号:
    10223398
  • 项目类别:
  • 资助金额:
    $20.34万
  • 财政年份:
    2020
  • 负责人:
    Richard Anthony Edward Edden
  • 依托单位:
海外基金