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Simultaneous Hadamard Editing of GABA and Glutathione

GABA 和谷胱甘肽的同时 Hadamard 编辑

基本信息

批准号：
9896825
负责人：
Richard Anthony Edward Edden
金额：
$ 36.78万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-05 至 2021-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9896825
关键词：
Amyotrophic Lateral Sclerosis Brain Brain region Cells Chemicals Clinical Communities Computer software Coupling Creatine Data Set Development Dimensions Disease Evolution Frequencies Functional disorder Glutathione Goals Human Hybrids Individual Laboratories Location Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurement Measures Mental disorders Methodology Methods Morphologic artifacts Neurosciences Neurotransmitters Non-Invasive Cancer Detection Oxidation-Reduction Oxidative Stress Parkinson Disease Pattern Phase Physiologic pulse Protocols documentation Reactive Oxygen Species Reproducibility Research Resolution Role Scanning Scheme Schizophrenia Shapes Signal Transduction Site Time base computerized data processing data acquisition design experimental study gamma-Aminobutyric Acid in vivo information processing innovation interest nervous system disorder neuroimaging prospective tool uptake

项目摘要

PROJECT SUMMARY Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest. Such “edited” approaches generally focus on measuring a single metabolite (i.e. either GABA or GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited experiments that detect GABA and GSH simultaneously, in a single acquisition. We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing, using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post- processing and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

项目总结编辑的磁共振波谱允许对低浓度的非侵入性检测大脑内的代谢物，如抑制性神经递质GABA和氧化还原复合谷胱甘肽(GSH)。这些代谢物的信号在磁共振中常常重叠。但量身定做的光谱编辑实验可以选择性地检索感兴趣的信号。这种“编辑过的”方法通常侧重于测量单一代谢物(即GABA或 GSH)；这项提议的主要目标是开发由Hadamard编辑的在一次采集中同时检测GABA和GSH的实验。我们将开发Hadamard编码的Hermes方法和多体素Hadamard编辑，使用夏尔巴人和赫尔墨斯-夏尔巴人的方法。由此产生的数据采集，后- 将提供处理和分析工具，以便分发给临床神经科学和神经成像社区。