Simultaneous Hadamard Editing of GABA and Glutathione

GABA 和谷胱甘肽的同时 Hadamard 编辑

• 批准号: 10366442
• 负责人: Richard Anthony Edward Edden
• 金额: $ 61.25万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-05 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10366442
• 关键词: Acceleration; Address; Age; Alzheimer' s Disease; Antioxidants; Biochemical; Brain; Chemicals; Clinical; Clinical Research; Communication; Communities; Computer software; Coupling; Data; Data Analyses; Data Set; Detection; Development; Disease; Florida; Foundations; Frequencies; Functional disorder; Funding; Glutathione; Goals; Grant; Human; Lead; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Masks; Measurement; Measures; Methodology; Methods; Modeling; Neurosciences; Neurotransmitters; Oxidation-Reduction; Oxidative Stress; Patients; Phase; Physiologic pulse; Predisposition; Protons; Relaxation; Reproducibility; Resolution; Scanning; Science; Signal Transduction; Site; Slice; Spectrum Analysis; Time; Tissues; Uncertainty; Universities; Weight; Work; base; clinical development; cohort; computerized data processing; data acquisition; experimental study; gamma-Aminobutyric Acid; improved; in vivo; innovation; interest; macromolecule; neuroimaging; novel; open source; reconstruction; sex; time use; tool; validation studies

Summary The neurotransmitter GABA and the redox compound glutathione can be measured in the human brain non- invasively using Hadamard-encoded edited MRS. Such measurements currently suffer from three major limitations: the confound of transverse relaxation (since edited MRS requires long echo times); incomplete spectral resolution between metabolites and the macromolecular background; and inadequate/inflexible modeling and quantification software. The overall goal of this R01 renewal period is to develop Hadamard- encoded edited MRS of GABA and Glutathione into a robust and reproducible tool for neuroscience. Building on the successful development of HERMES in the first funded period we will develop interleaved multi-spectrum acquisitions to improve robustness to changes in transverse relaxation and the macromolecule baseline and develop multi-spectrum linear combination methods within our software Osprey, including building a demographic model of the macromolecular background spectrum. This project will culminate in a patient-based validation study in subjects with Alzheimer’s Disease. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

总结 神经递质GABA和氧化还原化合物谷胱甘肽可以在人脑中测量， 这种测量目前受到三个主要的影响， 局限性：横向弛豫的混淆（因为编辑的MRS需要较长的回波时间）;不完整 代谢物和大分子背景之间的光谱分辨率;以及不充分/不灵活 建模和量化软件。R 01更新期的总体目标是开发Hadamard- 将GABA和谷氨酸的编辑MRS编码为神经科学的强大和可重复的工具。 在爱马仕在第一个资助期成功开发的基础上，我们将开发交错的 多光谱采集，以提高对横向弛豫和大分子变化的鲁棒性 在我们的软件Osprey中建立基线并开发多光谱线性组合方法，包括 建立大分子背景光谱的人口统计学模型。该项目将最终在一个 在阿尔茨海默病患者中进行的基于患者的验证研究。由此产生的数据采集和分析 将向临床神经科学和神经成像界提供传播工具。