Simultaneous Hadamard Editing of GABA and Glutathione

摘要 神经递质GABA和氧化还原复合谷胱甘肽可以在人脑中检测到 侵入性地使用Hadamard编码的编辑的MRS这种测量目前受到三个主要问题的影响 局限性：横向松弛混乱(因为编辑后的MRS需要较长的回声时间)；不完整 代谢物和大分子背景之间的光谱分辨率；不充分/不灵活 建模和量化软件。本次R01更新期的总体目标是发展Hadamard- 编码编辑的GABA和Glutathione的MRS成为一个强大的和可重复的神经科学工具。 在爱马仕在第一个资助期成功开发的基础上，我们将开发交错 多光谱采集以提高对横向弛豫和大分子变化的稳健性 在我们的软件Osprey中基线和开发多光谱线性组合方法，包括 建立大分子背景光谱的人口统计学模型。这一项目将以一项 阿尔茨海默病受试者的基于患者的验证研究。由此产生的数据采集和分析 将向临床神经科学和神经成像社区提供传播工具。

Summary The neurotransmitter GABA and the redox compound glutathione can be measured in the human brain non- invasively using Hadamard-encoded edited MRS. Such measurements currently suffer from three major limitations: the confound of transverse relaxation (since edited MRS requires long echo times); incomplete spectral resolution between metabolites and the macromolecular background; and inadequate/inflexible modeling and quantification software. The overall goal of this R01 renewal period is to develop Hadamard- encoded edited MRS of GABA and Glutathione into a robust and reproducible tool for neuroscience. Building on the successful development of HERMES in the first funded period we will develop interleaved multi-spectrum acquisitions to improve robustness to changes in transverse relaxation and the macromolecule baseline and develop multi-spectrum linear combination methods within our software Osprey, including building a demographic model of the macromolecular background spectrum. This project will culminate in a patient-based validation study in subjects with Alzheimer’s Disease. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.