Simultaneous Hadamard Editing of GABA and Glutathione

总结 神经递质GABA和氧化还原化合物谷胱甘肽可以在人脑中测量， 这种测量目前受到三个主要的影响， 局限性：横向弛豫的混淆（因为编辑的MRS需要较长的回波时间）;不完整 代谢物和大分子背景之间的光谱分辨率;以及不充分/不灵活 建模和量化软件。R 01更新期的总体目标是开发Hadamard- 将GABA和谷氨酸的编辑MRS编码为神经科学的强大和可重复的工具。 在爱马仕在第一个资助期成功开发的基础上，我们将开发交错的 多光谱采集，以提高对横向弛豫和大分子变化的鲁棒性 在我们的软件Osprey中建立基线并开发多光谱线性组合方法，包括 建立大分子背景光谱的人口统计学模型。该项目将最终在一个 在阿尔茨海默病患者中进行的基于患者的验证研究。由此产生的数据采集和分析 将向临床神经科学和神经成像界提供传播工具。

Summary The neurotransmitter GABA and the redox compound glutathione can be measured in the human brain non- invasively using Hadamard-encoded edited MRS. Such measurements currently suffer from three major limitations: the confound of transverse relaxation (since edited MRS requires long echo times); incomplete spectral resolution between metabolites and the macromolecular background; and inadequate/inflexible modeling and quantification software. The overall goal of this R01 renewal period is to develop Hadamard- encoded edited MRS of GABA and Glutathione into a robust and reproducible tool for neuroscience. Building on the successful development of HERMES in the first funded period we will develop interleaved multi-spectrum acquisitions to improve robustness to changes in transverse relaxation and the macromolecule baseline and develop multi-spectrum linear combination methods within our software Osprey, including building a demographic model of the macromolecular background spectrum. This project will culminate in a patient-based validation study in subjects with Alzheimer’s Disease. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.