Simultaneous Hadamard Editing of GABA and Glutathione

GABA 和谷胱甘肽的同时 Hadamard 编辑

• 批准号: 9286636
• 负责人: Richard Anthony Edward Edden
• 金额: $ 38.14万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-05 至 2021-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9286636
• 关键词: Amyotrophic Lateral Sclerosis; Brain; Brain region; Cells; Chemicals; Clinical; Communities; Computer software; Coupling; Creatine; Data Set; Development; Dimensions; Disease; Evolution; Frequencies; Functional disorder; Glutathione; Goals; Human; Hybrids; Individual; Laboratories; Location; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measurement; Measures; Mental disorders; Methodology; Methods; Morphologic artifacts; Neurosciences; Neurotransmitters; Non-Invasive Cancer Detection; Oxidation-Reduction; Oxidative Stress; Parkinson Disease; Pattern; Phase; Physiologic pulse; Protocols documentation; Reactive Oxygen Species; Reproducibility; Research; Resolution; Role; Scanning; Scheme; Schizophrenia; Shapes; Signal Transduction; Site; Time; base; computerized data processing; data acquisition; design; experimental study; gamma-Aminobutyric Acid; in vivo; information processing; innovation; interest; multiplet; nervous system disorder; neuroimaging; prospective; tool; uptake

PROJECT SUMMARY Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest. Such “edited” approaches generally focus on measuring a single metabolite (i.e. either GABA or GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited experiments that detect GABA and GSH simultaneously, in a single acquisition. We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing, using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post- processing and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

项目总结