TRD 2: Metabolic Markers
TRD 2:代谢标志物
基本信息
- 批准号:10270099
- 负责人:
- 金额:$ 17.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AffectAnatomyAntioxidantsBindingBiochemicalBiochemistryBiological MarkersBrainBrain ChemistryBrain imagingChemicalsCollaborationsCommunitiesCouplingDataData AnalysesData SetDetectionDevelopmentDiagnosisDiffusion Magnetic Resonance ImagingDiseaseFingerprintFunctional Magnetic Resonance ImagingGlutamatesGlutathioneImageLabelLeadLibrariesMachine LearningMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMagnetismMeasurementMeasuresMetabolicMetabolic MarkerMethodsModelingMolecularMonitorN-acetylaspartylglutamateNeurologicNeuromodulatorNeurotransmittersPhosphocreatinePhysiologic pulsePhysiologicalPreparationPrincipal InvestigatorPropertyProteinsProtonsRadiology SpecialtyRelaxationReproducibilityResearch PersonnelResolutionResourcesScheduleSchemeServicesShapesSignal TransductionSpecificitySystemTechniquesTestingTrainingValidationWateramplification detectionbasebrain abnormalitiesbrain metabolismdeep learningdesigndetection sensitivitygamma-Aminobutyric Acidimprovedinnovationinterestmacromoleculemetabolic imagingopen sourceprofessorresponsesmall moleculespectroscopic imagingstatisticssynergismtool
项目摘要
TRD 2: Metabolic Markers
Lead Principal investigator: Richard Edden, Professor of Radiology
Co-investigators: Peter van Zijl, Peter Barker, Georg Oeltzschner, Jiadi Xu, Hye-Young Heo,
Nirbhay Yadav.
This TRD will develop biomarkers of brain metabolism, using magnetic resonance spectroscopy
(MRS) and chemical exchange-saturation transfer imaging (CEST-MRI). We will develop new
editing schedules for multiplexed editing MRS, allowing the simultaneous resolution of several
low-concentration metabolites of interest to collaborative projects, including neurotransmitters
such as GABA, antioxidants such as glutathione, and neuromodulators such as N-
acetylaspartylglutamate. We will combine these methods with spectroscopic imaging readouts
and develop multi-spectrum linear combination modeling approached for quantification. Edited
CEST approaches, tuning acquisition parameters to improve specificity of detection, CEST
fingerprinting, and single-shot z-spectrum approaches will be developed. Deep learning tools
for the analysis of these data will also be developed, with a particular focus on the integration
of methods, and spectral resolution enhancement and metabolic editing by MRSI-based
training of CEST analyses. Acquisition and analysis tools developed under this TRD will be
disseminated to collaborative projects and service projects, to establish reproducibility in a new
setting, and to the broader community.
TRD 2:代谢标志物
首席研究员:Richard Edden,放射学教授
共同研究者:Peter货车Zijl,Peter Barker,Georg Oeltzschner,Jiadi Xu,Hye-Young Heo,
尼尔拜·亚达夫
该TRD将使用磁共振光谱学开发大脑代谢的生物标志物
(MRS)和化学交换饱和转移成像(CEST-MRI)。发展新型
多路编辑MRS的编辑时间表,允许同时解决几个
合作项目感兴趣的低浓度代谢物,包括神经递质
如GABA,抗氧化剂如谷胱甘肽,和神经调节剂如N-
乙酰基谷氨酸我们将联合收割机与光谱成像读数结合起来
并建立了多光谱线性组合模型定量方法。编辑
CEST方法,调整采集参数以提高检测特异性,
将开发指纹识别和单次激发z谱方法。深度学习工具
还将开发这些数据的分析,特别注重整合
的方法,并通过基于MRI的光谱分辨率增强和代谢编辑
CEST分析培训。在本技术建议文件下开发的采集和分析工具将
传播到合作项目和服务项目,以建立一个新的可重复性
#21453;,以及更广泛的社区。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Richard Anthony Edward Edden其他文献
Richard Anthony Edward Edden的其他文献
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{{ truncateString('Richard Anthony Edward Edden', 18)}}的其他基金
Edited Magnetic Resonance Spectroscopy of the Pediatric Brain
儿科大脑磁共振波谱编辑
- 批准号:
10583752 - 财政年份:2023
- 资助金额:
$ 17.5万 - 项目类别:
Measuring Altered Glutathione in Children with Autism Spectrum Disorder
测量自闭症谱系障碍儿童的改变谷胱甘肽
- 批准号:
10223398 - 财政年份:2020
- 资助金额:
$ 17.5万 - 项目类别:
Measuring Altered Glutathione in Children with Autism Spectrum Disorder
测量自闭症谱系障碍儿童的改变谷胱甘肽
- 批准号:
10055287 - 财政年份:2020
- 资助金额:
$ 17.5万 - 项目类别:
Neurometabolic profile of mild cognitive impairment using multiplexed edited MRS
使用多重编辑 MRS 分析轻度认知障碍的神经代谢特征
- 批准号:
9759752 - 财政年份:2018
- 资助金额:
$ 17.5万 - 项目类别:
Simultaneous Hadamard Editing of GABA and Glutathione
GABA 和谷胱甘肽的同时 Hadamard 编辑
- 批准号:
9286636 - 财政年份:2017
- 资助金额:
$ 17.5万 - 项目类别:
Simultaneous Hadamard Editing of GABA and Glutathione
GABA 和谷胱甘肽的同时 Hadamard 编辑
- 批准号:
10495231 - 财政年份:2017
- 资助金额:
$ 17.5万 - 项目类别:
Simultaneous Hadamard Editing of GABA and Glutathione
GABA 和谷胱甘肽的同时 Hadamard 编辑
- 批准号:
10366442 - 财政年份:2017
- 资助金额:
$ 17.5万 - 项目类别:
Simultaneous Hadamard Editing of GABA and Glutathione
GABA 和谷胱甘肽的同时 Hadamard 编辑
- 批准号:
9896825 - 财政年份:2017
- 资助金额:
$ 17.5万 - 项目类别:
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