Neuroscience: From Channels to Behavior

神经科学：从渠道到行为

• 批准号: 10615865
• 负责人: Leslie C Griffith
• 金额: $ 32.12万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10615865
• 关键词: Behavior; Neurosciences

Project Summary/Abstract Over the 24 year tenure of this grant, Brandeis has built a multi-disciplinary program encompassing faculty in Biology, Biochemistry, Chemistry, Mathematics and Psychology. We educate students in the full range of Neuroscience topics from the molecular biology of neuronal non-coding RNAs to the cognitive effects of aging. Each member of our faculty collaborates with multiple others, and most projects involve several levels of analysis. Our students are part of an intellectually and spatially integrated neuroscience community. The resulting cohesion is reflected in every aspect of the program: coursework, rotations, thesis supervision, the shared availability of advanced instrumentation and the collegiality of interactions. The breadth of opportunity and interaction at Brandeis and close attention we pay to student progress allows each student to develop according to her/his individual needs, and results in a low attrition rate. While we are a relatively small program, over the last five years our program has graduated 18 students (3 of whom were members of underrepresented minority groups). Our students graduate with excellent credentials and go on to obtain positions in academia, health-care, government and industry that directly contribute to the NIH mandate to benefit human health. Our students enter Neuroscience from a remarkably wide variety of different backgrounds (Psychology, Biology, Biochemistry, Chemistry, Physics, Computer Science, Engineering, and Mathematics). A strong aspect of our program has always been its emphasis on quantitative thinking. Every area of Neuroscience is increasingly driven by large data sets and all Neuroscientists must be able to at least understand the principles of their analysis. In this renewal we rethink our approach to quantitative literacy and propose a curricular reform that will train our students in the fundamentals of quantitation rather than in specific high level methods. By giving them computational tools and by teaching them to code, all of our students will have a solid foundation for rigorous research at any level. The program of course work, rotations, multiple small-group colloquia, proposition exams, and participation in teaching necessarily consumes the bulk of a student's time during the first two years. They cannot (and we would not want them to) have their laboratory research as their sole focus prior to their third year at Brandeis. Therefore, they are not supported on research grants in these first critical years. This training grant provides crucial funding to support students while they develop a broad set of intellectual skills. There are 22 mentors in our program and we are requesting funds for 8 trainees.

项目总结/摘要 在这项赠款的24年任期内，布兰迪斯建立了一个多学科的计划，包括教师在 生物学、生物化学、化学、数学和心理学。我们教育学生在全方位的 神经科学的主题从神经元非编码RNA的分子生物学到衰老的认知影响。 我们的教师的每个成员与多个其他人合作，大多数项目涉及几个层次的 分析.我们的学生是智力和空间整合神经科学社区的一部分。的 由此产生的凝聚力反映在程序的各个方面：课程，轮换，论文监督， 先进仪器的共享和互动的协作。 在布兰迪斯的机会和互动的广度和密切关注，我们支付给学生的进步允许 每个学生都可以根据自己的需要发展，从而降低流失率。虽然我们是一个 相对较小的计划，在过去的五年里，我们的计划已经毕业18名学生（其中3人是 代表性不足的少数群体成员）。我们的学生以优异的证书毕业，并继续 在学术界、卫生保健、政府和工业界获得直接有助于NIH任务的职位 有益于人类健康。 我们的学生进入神经科学从一个非常广泛的不同背景（心理学， 生物学、生物化学、化学、物理学、计算机科学、工程学和数学）。一个强大 我们计划的一个方面一直是强调定量思维。神经科学的每个领域都是 越来越多地由大型数据集驱动，所有神经科学家必须至少能够理解这些原理 他们的分析。在这次更新中，我们重新思考了我们的定量识字方法，并提出了一个课程， 改革，将培养我们的学生在基本的定量，而不是在具体的高层次的方法。 通过给他们计算工具，教他们编码，我们所有的学生都将有一个坚实的 为任何级别的严谨研究奠定基础。 课程工作，旋转，多个小组座谈会，命题考试和参与的计划 在头两年里，教学必然会消耗学生的大部分时间。他们不能（我们） 我不希望他们）有他们的实验室研究作为他们的唯一重点之前，他们的第三年在布兰代斯。 因此，在这些最初的关键年份，他们没有得到研究赠款的支持。该培训补助金提供 重要的资金，以支持学生，而他们发展了广泛的智力技能。有22位导师在 我们的计划，我们正在申请8名学员的资金。

项目成果

Primary cilia in the postnatal brain: Subcellular compartments for organizing neuromodulatory signaling.

• DOI: 10.1016/j.conb.2022.102533
• 发表时间: 2022-06
• 期刊: Current opinion in neurobiology
• 影响因子: 5.7

Neuroanatomical Correlates of Perceived Stress Controllability in Adolescents and Emerging Adults.

• DOI: 10.3758/s13415-022-00985-2
• 发表时间: 2022-08
• 期刊: COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
• 影响因子: 2.9
• 作者: Fassett-Carman, Alyssa N.;Smolker, Harry;Hankin, Benjamin L.;Snyder, Hannah R.;Banich, Marie T.
• 通讯作者: Banich, Marie T.

Potential synergistic action of 19 schizophrenia risk genes in the thalamus.

丘脑中19个精神分裂症风险基因的潜在协同作用。

• DOI: 10.1016/j.schres.2016.09.008
• 发表时间: 2017-02
• 期刊: Schizophrenia research
• 影响因子: 4.5
• 作者: Richard EA;Khlestova E;Nanu R;Lisman JE
• 通讯作者: Lisman JE

Coherent Coding of Spatial Position Mediated by Theta Oscillations in the Hippocampus and Prefrontal Cortex.

海马和前额叶皮层 Theta 振荡介导的空间位置的连贯编码。

• DOI: 10.1523/jneurosci.0106-19.2019
• 发表时间: 2019
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Zielinski,MarkC;Shin,JustinD;Jadhav,ShantanuP
• 通讯作者: Jadhav,ShantanuP

The GTPase Rem2 regulates synapse development and dendritic morphology.

• DOI: 10.1002/dneu.20868
• 发表时间: 2011-05
• 期刊: DEVELOPMENTAL NEUROBIOLOGY
• 影响因子: 3
• 作者: Ghiretti, Amy E.;Paradis, Suzanne
• 通讯作者: Paradis, Suzanne