Child Health Research Career Development Award (CHRCDA) Program (K12)

项目摘要/摘要 波士顿儿童医院K12 CHRCDA项目的目标是培养独立的儿科医生 医生-科学家，他们将破译儿童疾病的病原体，并开发出变革性的新技术 治疗。我们的学者将在以下导师的指导下进行基于实验室的基础和翻译研究 波士顿儿童医院及其他附属机构的杰出科学家。我们的节目一直是 设立的目的是确保该领域杰出的独立儿科医生和科学家的持续发展。 在这份提案中，我们描述了一项计划，其中包括强化指导、全面的教学计划、 以及适当的监督和支持，以确保我们的学者发挥其最大的科学潜力。 方案监督将由外部咨询委员会和内部指导委员会提供。 已经制定了方案自我评估和审查学术进展的计划。我们建议继续 三个学者职位的经费。奖学金获得者将获得至少两年的资助，具体时间取决于 研究和职业发展活动取得令人满意的进展，以及学者候选人的总体人数。 学者通常是讲师级别的教员，但助理教授是早期的 他们的独立职业发展也将有资格申请。学者将在任何时候被考虑 从他们开始担任导师到他们被认为两年后才提交 他们的第一笔R-Level NIH奖学金或同等资助金，但在奖学金培训结束后不超过四年。 学者们将在与儿童健康相关的广泛科学调查领域工作。古今学者 研究了罕见儿童疾病的基因组学，发育生物学，粘膜免疫学，宿主- 微生物相互作用、单基因肾病、癫痫遗传学和环境对早期脑的影响 发展。我们的学者有望阐明疾病的分子机制，导致 为广泛的儿童疾病开发变革性的新疗法。

PROJECT SUMMARY / ABSTRACT The goal of the Boston Children's Hospital K12 CHRCDA Program is to develop independent pediatrician physician-scientists who will decipher the pathobiology of childhood disease and develop transformative new therapies. Our Scholars will perform laboratory-based basic and translational research under the mentorship of outstanding scientists at Boston Children's Hospital and other affiliated institutions. Our program has been established to ensure the continued development of outstanding independent pediatrician-scientists in the field. In this proposal, we describe a program that includes intensive mentoring, a comprehensive didactic program, and appropriate supervision and support to ensure that our Scholars reach their maximum scientific potential. Programmatic oversight will be provided by an External Advisory Committee and an Internal Steering Committee. Plans are in place for programmatic self-evaluation and for review of Scholar Progress. We propose to continue the funding of three Scholar positions. Scholars will be funded for a minimum of two years, contingent on satisfactory progress on research and career development activities, and the overall pool of Scholar candidates. Scholars will be faculty members most often at the rank of Instructor, but Assistant Professors who are early in the development of their independent careers will also be eligible to apply. Scholars will be considered at any point from the beginning of their Instructorship until they are considered to be two years away from submitting their first R-level NIH grant or equivalent, though no more than four years beyond the end of fellowship training. Scholars will work in broad areas of scientific investigation relevant to child health. Past and present Scholars have studied the genomics of rare childhood disease, developmental biology, mucosal immunology, host- microbe interactions, monogenic kidney diseases, genetics of epilepsy, and environmental effects on early brain development. Our Scholars are expected to elucidate molecular mechanisms of disease, leading to the development of transformative new therapies for a broad range of diseases of childhood.