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Research Bronchoscopy and Biospecimens Core

研究支气管镜检查和生物样本核心

基本信息

批准号：
10269968
负责人：
Homer L Twigg
金额：
$ 30.26万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10269968
关键词：
Address Area Asthma Basic Science Biopsy Blood Blood specimen Bronchoalveolar Lavage Bronchoscopy Cells Clinical Clinical Sciences Clinical Trials Data Coordinating Center Databases Dimethyl Sulfoxide Disease Ensure Environment Freezing Future Genomics Goals Human Imaging Techniques In Vitro Indiana Infrastructure Institutes Label Lead Link Liquid substance Lung Measurement Metadata Nitrogen Patients Peripheral Blood Mononuclear Cell Plasma Prevention approach Process Proteomics Protocols documentation RNA Research Research Personnel Research Project Grants Resources Sampling Scientist Serum Services Specimen Specimen Handling Study Subject Time Time Study Tissues Translational Research Universities Work base biobank clinically relevant design experimental study feasibility research human tissue innovation insight interest novel strategies preservation programs recruit skills translational scientist translational study

项目摘要

PROJECT SUMMARY/ABSTRACT Core B: Bronchoscopy and Biospecimens The goal of this core is four-fold. First, the core is responsible for performing bronchoscopy on study subjects to obtain all the necessary lung specimens for in vitro experiments. This includes collecting all the appropriate control specimens at the time of study. Second, the core is responsible for processing specimens in such a way that they can either be used real time or stored appropriately for future use. This includes coordination of processing and storage protocols between labs. Third, the core is responsible for aliquoting samples in appropriate sizes and conditions (i.e. RNA preservation media, DMSO) for storage in appropriate environments (i.e. -80o freezer, liquid nitrogen) for future studies. Finally, the core is responsible for labeling and tracking all specimens, including the linkage of specimens to subject metadata. By providing uniform specimens to all investigators the core can ensure interdisciplinary integration of the multiple projects that make up the combined Program Project.

项目总结/摘要核心B：支气管镜检查和生物标本这个核心的目标有四个方面。首先，核心负责对研究对象进行支气管镜检查以获得体外实验所需的所有肺标本。这包括收集所有在研究时使用适当的对照样本。第二，核心负责处理标本的方式，他们可以使用真实的时间或适当地储存供将来使用。这包括协调实验室之间的处理和存储协议。三是核心负责将样品等分至适当大小和条件（即RNA保存培养基，DMSO），储存于适合未来研究的环境（即-80 ℃冰箱、液氮）。最后，核心是责任用于标记和跟踪所有标本，包括标本与受试者元数据的链接。通过提供统一的标本，以所有研究者的核心，可以确保跨学科的多个项目的整合组成了联合计划项目。