Project 2 - TB Translation as a Target

项目 2 - TB 翻译作为目标

• 批准号: 10242864
• 负责人: JAMES C SACCHETTINI
• 金额: $ 50.26万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242864
• 关键词: Anti-Bacterial Agents; Antibiotics; Bacteria; Biological Assay; Biology; Capromycin; Cells; Chemicals; Collaborations; Complex; Cryoelectron Microscopy; Development; Drug Targeting; Energy Metabolism; Environment; Enzymes; Genomics; Genus Mycobacterium; Goals; Human; Infection; Lead; Link; Lung; Mediating; Membrane; Metabolic; Mitochondria; Mycobacterium tuberculosis; Nucleic Acids; Pathway interactions; Peptides; Phase; Play; Process; Protein Biosynthesis; Proteins; Proteomics; RNA; Regulation; Regulatory Pathway; Ribosomes; Role; Series; Streptomycin; Structure; Techniques; Technology; Translations; Work; X-Ray Crystallography; antimicrobial; base; cell growth; drug development; inhibitor/antagonist; mycobacterial; novel; novel therapeutics; programs; scaffold; small molecule inhibitor; structural biology; translation factor; tuberculosis drugs

Translation plays a key role in the survival of any cell and is a hub for many regulatory pathways that control cellular growth. Due to this complexity, the ribosome has proven to be a vulnerable antibiotic target and several existing antituberculous compounds block translation. We have capitalized on recent advances in cryo-EM techniques to explore the unique structural aspects of the mycobacterial ribosome that might alter antimicrobial efficacy and be exploited by new therapeutics.

翻译在任何细胞的生存中起着关键作用，并且是许多调节途径的枢纽， 控制细胞生长。由于这种复杂性，核糖体已被证明是一种脆弱的抗生素 靶点和几种现有的抗结核化合物阻断翻译。我们利用了最近 冷冻电镜技术在探索分枝杆菌核糖体独特结构方面的进展 这可能会改变抗菌效果，并被新的治疗方法所利用。