Interaction of Emotional Perception and Visual Attention

情绪感知和视觉注意力的相互作用

• 批准号: 10242930
• 负责人: LUIZ PESSOA
• 金额: $ 66.47万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-19 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10242930
• 关键词: Address; Amygdaloid structure; Animals; Anterior; Anxiety Disorders; Area; Aversive Stimulus; Basic Science; Behavior; Behavioral; Brain; Brain region; Calcium; Clinical; Cognition; Coin; Collaborations; Communities; Conflict (Psychology); Data; Data Analyses; Desire for food; Development; Dimensions; Emotional; Emotions; Functional Magnetic Resonance Imaging; Grant; Graph; Hippocampus (Brain); Human; Image; Individual; Insula of Reil; Knowledge; Link; Literature; Location; Machine Learning; Motivation; Movement; Neurons; Participant; Peer Review; Perception; Positioning Attribute; Prefrontal Cortex; Procedures; Process; Publications; Publishing; Research; Research Personnel; Rewards; Rodent; Role; Safety; Series; Stimulus; Structure of terminal stria nuclei of preoptic region; Substance abuse problem; Techniques; Testing; Time; Ventral Striatum; Vision; Visual attention; Work; aversive conditioning; brain behavior; cingulate cortex; classical conditioning; conditioning; experience; experimental study; face perception; gang; midbrain central gray substance; reward processing; stem; virtual

The understanding of the brain mechanisms of emotion and motivation has grown steadily in the past two decades. The majority of the work in the rodent and human literatures has relied heavily on particular paradigms, such as the perception of faces with emotion content in humans, and aversive conditioning procedures in both humans and animals. The present application proposes a series of experimental paradigms that are ecologically inspired, semi- naturalistic, and dynamic. The objective of this application is to investigate the dynamics of threat processing during escape behaviors, as well as the dynamics of threat/reward processing during approach- avoid conflict paradigms. Across experiments, we seek to both characterize and test specific hypotheses centered around a set of brain regions implicated in aversive and appetitive processing. We seek to characterize their contributions individually but also as distributed circuits that collectively and dynamically support behaviors. The proposed work is organized around two aims. Aim 1 investigates the circuits supporting threat escape. Rodent studies suggest that the ventral striatum/accumbens is an important node during escape behaviors. Whereas some work in humans (e.g., avoidance conditioning) supports this notion, other work with ethologically inspired paradigms has also revealed the participation of regions such as the mid-cingulate cortex and the anterior hippocampus. Experiments will test the contributions of these and other brain regions to escape mechanisms. Aim 2 investigates the circuits involved in aversive and appetitive interactions during dynamic threat and reward processing. Experiments will employ dynamic stimuli where the proximity to threat and reward vary dynamically. Collectively, the work addresses a set of basic research questions aimed at understanding how emotion/motivation circuits outlined in the past decades supports dynamic processing. The potential results may inform the clinically-oriented human literature, which has been heavily informed and inspired by research with standard experimental paradigms.

对情绪和动机的大脑机制的理解在20世纪稳步增长。 过去二十年啮齿动物和人类文献中的大多数工作都依赖于 严重依赖于特定的范式，例如对具有情感内容的面部的感知， 人类，以及人类和动物的厌恶性条件反射程序。本 应用程序提出了一系列的实验范式，是生态启发，半， 自然的，动态的。 这个应用程序的目的是调查威胁处理的动态 在逃跑行为中，以及在接近过程中威胁/奖励处理的动态- 避免范式冲突。在整个实验中，我们寻求表征和测试特定的 假设围绕着一组与厌恶和食欲有关的大脑区域， 处理.我们力求将它们的贡献分别加以描述，但同时也将它们的贡献加以分配 共同地和动态地支持行为的电路。 拟议的工作围绕两个目标展开。目标1研究电路 支持威胁逃脱。啮齿类动物的研究表明，腹侧纹状体/纹状体是一个 逃逸行为中的重要节点。而有些人在人类中工作（例如，避免 条件作用）支持这一概念，其他具有行为学启发范式的工作也 揭示了参与的区域，如中扣带皮层和前 海马体。实验将测试这些和其他大脑区域对逃避的贡献 机制等目的2研究厌恶和欲望相互作用中涉及的回路 在动态威胁和奖励处理过程中。实验将采用动态刺激， 与威胁和奖励的接近度动态地变化。 总的来说，这项工作解决了一系列基础研究问题， 了解过去几十年中概述的情绪/动机回路如何支持动态 处理.潜在的结果可能会告知临床导向的人类文献， 从标准实验范式的研究中获得了大量信息和灵感。