Dynamics of Large-Scale Networks During Emotional and Social Processing

这个应用程序的目标是开发一个研究计划，正如题为 多维情绪和社会表征的神经机制(RFA-MH- 17-300)，结合了旨在推动情感和社交领域的创新方法 超越脑功能的单一区域、模块化和静态模型的神经科学 行为。RFA呼吁进行多维度的研究，即调查角色 复杂的上下文以及分布式和/或动态的过程 随着时间的推移而展开。本申请的目的是联合调查情感和 以丰富的多维方式进行的社会进程。 目标1：情绪和社会加工过程中的网络组织和进化。这个 这一目标的目的是揭示大规模大脑网络是如何组织和进化的 在情绪和社交过程中暂时的。网络将包括大脑区域，这些区域 有力地响应提出的任务，以及来自具有良好特色的网络的地区， 包括显著网络、执行控制网络和任务负网络。目标2：自然主义 在情绪和社交过程中的处理。这个目标的目的是理解 情感和社会信息的自然处理。虽然是标准的实验 设计提供了对实验条件的极大控制，它们缺乏生态有效性和 限制可以研究的实验。我们建议继续调查 (自然主义的)观影过程中涉及情感和社会内容的。 连续加工将通过受试者之间的相关性分析进行调查， 衡量信号在参与者之间的关联程度。目标3：发展 网络组织/进化和自然主义加工。这一目标的目的是 从发展的角度考察多维的情感和社会过程 透视。大多数情绪发育研究都集中在观察杏仁核上 面孔感知过程中的反应和其他几个大脑区域的反应。我们集中在一个问题上 在以前的研究中基本上被忽视了，特别是持续的威胁处理和参与 终纹的床核。在社会处理的背景下，这一目标考察 学科间同步性的发展。在情感和社交领域，我们 建议研究儿童期中期(8-9岁)、青春期早期(12-13岁)和成年初期 (18-19岁)。

The goal of this application is to develop a research program that, as stated in the call entitled The Neural Mechanisms of Multi-Dimensional Emotional and Social Representation (RFA-MH- 17-300), incorporates innovative approaches designed to move the fields of affective and social neuroscience beyond single region-based, modular, and static models of brain function and behavior. The RFA calls for research that is multi-dimensional, that is, that investigates the role of (among others) complex contexts, as well as distributed and/or dynamic processes that unfold over time. The objective of the present application is to jointly investigate emotional and social processes in a richly multi-dimensional manner. Aim 1: Network organization and evolution during emotional and social processing. The objective of this aim is to uncover how large-scale brain networks are organized and evolve temporally during emotional and social processing. Networks will include brain regions that robustly respond to the tasks proposed, and regions from well characterized networks, including the salience, executive control, and task-negative networks. Aim 2: Naturalistic processing during emotional and social processing. The objective of this aim is to understand naturalistic processing of emotional and social information. Although standard experimental designs afford great control over experimental conditions, they lack ecological validity and restrict the experiments that can be studied. We propose to investigate continuous (“naturalistic”) processing during movie watching involving emotional and social content. Continuous processing will be investigated via intersubject correlation analysis, which measures the extent to which signals are correlated across participants. Aim 3: Development of network organization/evolution and naturalistic processing. The objective of this aim is to investigate multi-dimensional emotional and social processes from a developmental perspective. Most developmental research in emotion has focused on observing amygdala responses and those of a few other brain regions during face perception. We focus on a question largely neglected in prior research, specifically sustained threat processing and the involvement of the bed nucleus of the stria terminalis. In the context of social processing, this aim examines the development of intersubject synchrony. Across the emotional and social domains, we propose to study middle childhood (8-9 y), early adolescence (12-13 y), and young adulthood (18-19 y).