Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)

社区积极研究暴露研究 (CARES) 的保留、维护和加强

• 批准号: 10621715
• 负责人: Erin N Haynes
• 金额: $ 36.86万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-06 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621715
• 关键词: Acceleration; Adolescent; Adult; Age; Air; Anatomy; Applications Grants; Biological; Biological Markers; Blood; Brain; Caregivers; Chemistry; Chicago; Child; Childhood; Cohort Studies; Collaborations; Communities; Community Developments; Data; Data Management Resources; Data Set; Development; Dust; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Equipment and supply inventories; Etiology; Evaluation; Exposure to; Funding; Grant; Growth and Development function; Hair; Home; Illinois; Infrastructure; Knowledge; Lab On A Chip; Laboratories; Longevity; Magnetic Resonance Imaging; Maintenance; Manganese; Measurement; Measures; Metals; Methods; Motor; National Institute of Environmental Health Sciences; Neuroanatomy; Neurodevelopmental Deficit; Neuropsychology; Ohio; Outcome; Parents; Participant; Pediatric cohort; Pediatric epidemiology; Physiology; Play; Police; Population; Psychosocial Factor; Reporting; Resources; Role; Saliva; Sampling; Scientific Advances and Accomplishments; Scientist; Serum; Side; Soil; Structure of nail of toe; Time; Training; United States; Urine; Water; Whole Blood; biobank; cohort; community engaged research; data management; data sharing; deciduous tooth; early childhood; improved; innovation; neurodevelopment; next generation; novel; participant retention; patient engagement; point of care; preservation; primary caregiver; research study; sensor; toxicant

PROJECT SUMMARY Manganese (Mn) plays an essential role in normal growth and development The Communities Actively Researching Exposure Study (CARES) was built upon community-engaged research practices. Participants reside in three communities with the nation's highest levels of ambient Mn: Marietta and East Liverpool, Ohio, and Southeast Side Chicago, Illinois. The CARES cohort consists of over 600 children and their primary caregiver, with two time-points (ages 7-9 years and ages 13-17 years) of extensive neurodevelopmental outcomes, biomarkers of exposure, and home environmental measures. The CARES has been supported by multiple NIEHS-funded grants and has been instrumental in the training of next generation community- engaged environmental health scientists for over a decade. The cohort has been instrumental in the development of a lab-on-a-chip sensor for blood metals assessment and is currently exploring the impact of Mn on neuroanatomy, function, chemistry, and physiology through magnetic resonance imaging. Through this project, the CARES research team will be able to conduct the following: Aim 1) Maintain the integrity of the CARES cohort by implementing community-engaged research strategies to improve participant retention; Aim 2) Expand CARES to enhance characterization of critical windows of exposure across the lifespan, and assess the role of caregiver, child, and community-level psychosocial factors on the etiology of toxicant-induced neurodevelopmental deficits; and Aim 3) Maintain and enhance biorepository and data management infrastructure and develop methods to implement data sharing. The CARES is the only cohort poised to investigate ambient exposure to Mn and its relationship to brain function in both a pediatric and adolescent population. The proposed cohort retention, enhancement, and maintenance plans will accelerate and sustain the ability of the CARES cohort to investigate the impact of ambient Mn on neurodevelopmental outcomes, inform federal polices related to ambient exposure to Mn, and serve as a valuable resource for environmental health science trainees and scientists across the globe.

项目概要 锰 (Mn) 在正常生长和发育中发挥着重要作用 社区积极行动 研究暴露研究 (CARES) 建立在社区参与的研究实践的基础上。参加者 居住在全国环境锰含量最高的三个社区：俄亥俄州的玛丽埃塔和东利物浦， 和伊利诺伊州芝加哥东南部。 CARES 队列由 600 多名儿童及其小学组成 照顾者，有两个时间点（7-9 岁和 13-17 岁）进行广泛的神经发育 结果、暴露的生物标志物和家庭环境措施。 CARES 得到了以下机构的支持： 多项 NIEHS 资助的赠款，在培训下一代社区方面发挥了重要作用 与环境健康科学家合作十多年。该队列在以下方面发挥了重要作用： 开发用于血液金属评估的芯片实验室传感器，目前正在探索其影响 通过磁共振成像了解 Mn 对神经解剖学、功能、化学和生理学的影响。通过这个 项目后，CARES 研究团队将能够进行以下工作： 目标 1) 维护项目的完整性 CARES 队列通过实施社区参与的研究策略来提高参与者的保留率；目的 2) 扩展 CARES，以增强整个生命周期关键暴露窗口的特征，并评估 照顾者、儿童和社区心理社会因素对毒物诱发的病因的作用 神经发育缺陷；目标 3) 维护和加强生物样本库和数据管理 基础设施并开发实现数据共享的方法。 CARES 是唯一准备好 研究儿童和青少年的锰环境暴露及其与脑功能的关系 人口。拟议的队列保留、增强和维护计划将加速并维持 CARES 队列研究环境锰对神经发育结果影响的能力， 告知与环境中锰暴露相关的联邦政策，并作为环境的宝贵资源 全球健康科学学员和科学家。