Marietta Community Actively Researching Exposure Study

玛丽埃塔社区积极开展暴露研究

• 批准号: 8040947
• 负责人: Erin N Haynes
• 金额: $ 45.85万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8040947
• 关键词: Address; Adult; Affect; Age; Air; Air Pollution; Alloys; Ammonia; Animal Feed; Animals; Apoptosis; Attention; Automobile Driving; Awareness; Biochemical; Biological; Biological Markers; Blood; Blood - brain barrier anatomy; Brain; Breathing; Canada; Censuses; Child; Child Development; Chinese People; Chronic; Code; Cognitive; Collection; Communities; Complex; County; Cyclohexanes; Data; Databases; Deposition; Development; Dietary Manganese; Differentiation and Growth; Distress; Dopamine; Dose; Dust; Elements; Environmental Exposure; Environmental Health; Environmental Risk Factor; Exhibits; Exposure to; Eye Burns; Fertilizers; Fetus; Fright; Functional disorder; Future; Gasoline; Hair; Headache; Health; Health Policy; Home environment; Human; Industry; Infant; Knowledge; Language Tests; Lead; Literature; Location; Long-Term Effects; Manganese; Manuals; Marketing; Mathematics; Measures; Memory; Mental disorders; Metal exposure; Metallic Tastes; Metals; Methanol; Methods; Mexico; Modeling; Moods; Motor; Muscle Fatigue; Myalgia; Nail plate; Nausea; Neighborhoods; Neonatal; Neuraxis; Neurodevelopmental Deficit; Neurologic; Neurotoxins; Newborn Infant; Nose; Odors; Ohio; Oral; Oral cavity; Outcome; Parkinsonian Disorders; Particle Size; Particulate; Pathway interactions; Performance; Personal Financing; Pharyngeal structure; Pilot Projects; Placenta; Plants; Policies; Pollution; Population; Predisposition; Preventive Intervention; Process; Public Health; Quality Control; Rattus; Reaction Time; Recruitment Activity; Regulation; Relative (related person); Reporting; Research; Research Design; Research Project Grants; Resources; Risk; Rural; Sampling; Scientific Advances and Accomplishments; Sensory; Smell Perception; Sore Throat; Source; Specimen; Steel; Study Section; Symptoms; Taste Perception; Testing; Time; Tooth structure; Toxic Environmental Substances; Toxicant exposure; Training; Tremor; United States Environmental Protection Agency; Universities; Visual; Washington; Water; advocacy organizations; air monitoring; base; dissemination research; drinking water; early childhood; ferrite; interest; meetings; member; neurobehavior; neurobehavioral; neurodevelopment; neuropsychiatry; neurotoxic; neurotoxicity; newspaper article; particle; respiratory; response; sample collection; symposium

DESCRIPTION (provided by applicant): Manganese (Mn) is an essential element, yet is neurotoxic in excess. Despite the fact that infants and young children may be at greater risk for Mn neurotoxicity than adults, very few studies have evaluated the effect of chronic Mn exposure on child development. Marietta, Ohio, a rural Appalachian community, has been home to the only metal refinery in the US and Canada for over 50 years. In response, the community formed Neighbors for Clean Air (NCA). The University of Cincinnati (UC) has been asked by NCA to assist them in understanding their exposure and related health effects, if any. For this project, Marietta Community Actively Researching Exposure Study (CARES), the community has defined the research agenda, determining the research questions, objectives, specific aims and identifying resources available within the community to conduct the research. Members of the community will be engaged in all facets of the research project, including environmental sampling, neurobehavioral assessment, project coordination, and collection of biological specimens. The primary objectives of this application are to examine biological indicators of Mn exposure in children and understand the effects of chronic manganese exposure in children. UC will provide training, oversight and expertise in environmental health research, to address the following hypothesis: Exposure to Mn during early childhood is significantly associated with neurodevelopmental deficits in high exposed children ages 7-8 years compared to an age matched low/unexposed group. In order to test the hypothesis, the following community-driven specific aims will be accomplished. Specific Aim 1: Assess environmental Mn exposure within a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 2: Evaluate comparisons of the neurobehavioral effects in children exposed to Mn in a high Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Specific Aim 3: Evaluate comparisons of the neuromotor effects in children exposed to Mn exposure community, Marietta, OH and a low Mn exposure community, Cambridge, Ohio. Given the unique susceptibility of children to toxicant exposure and the opportunity to study Mn exposure in a chronically exposed community, we anticipate this project to significantly impact local and national public health policy related to Mn exposure. Project Narrative Exposure: to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children. PUBLIC HEALTH RELEVANCE: Exposure to manganese (Mn) can result in neurological deficiencies, and here is great potential for global exposure to Mn in the form of MMT, an anti-knock agent to replace lead in gasoline. The Marietta Community Actively Researching Exposure Study (CARES) is a community-based study designed to explore the health effects of long term Mn exposure in children.

描述（由申请人提供）： 锰 (Mn) 是一种必需元素，但过量会产生神经毒性。尽管婴儿和幼儿可能比成人面临更大的锰神经毒性风险，但很少有研究评估长期接触锰对儿童发育的影响。俄亥俄州玛丽埃塔是一个阿巴拉契亚乡村社区，50 多年来一直是美国和加拿大唯一的金属精炼厂所在地。作为回应，社区成立了清洁空气邻居组织 (NCA)。 NCA 已要求辛辛那提大学 (UC) 协助他们了解其接触情况以及相关的健康影响（如果有）。对于玛丽埃塔社区积极研究暴露研究 (CARES) 项目，社区定义了研究议程，确定研究问题、目的、具体目标，并确定社区内可用于开展研究的资源。社区成员将参与该研究项目的各个方面，包括环境采样、神经行为评估、项目协调和生物标本采集。该应用的主要目的是检查儿童锰暴露的生物指标并了解儿童慢性锰暴露的影响。加州大学将提供环境健康研究方面的培训、监督和专业知识，以解决以下假设：与年龄匹配的低/未接触组相比，幼儿期接触锰与 7-8 岁高接触锰儿童的神经发育缺陷显着相关。为了检验该假设，将实现以下社区驱动的具体目标。具体目标 1：评估俄亥俄州玛丽埃塔市高锰暴露社区和俄亥俄州剑桥低锰暴露社区内的环境锰暴露。具体目标 2：评估俄亥俄州玛丽埃塔高锰暴露社区和俄亥俄州剑桥低锰暴露社区中接触锰的儿童神经行为影响的比较。具体目标 3：评估暴露于俄亥俄州玛丽埃塔市锰暴露社区和俄亥俄州剑桥市低锰暴露社区的儿童神经运动影响的比较。鉴于儿童对有毒物质暴露的独特敏感性以及在长期暴露社区中研究锰暴露的机会，我们预计该项目将显着影响与锰暴露相关的地方和国家公共卫生政策。项目叙述暴露：接触锰 (Mn) 会导致神经缺陷，而全球以 MMT 形式接触锰的潜力巨大，MMT 是一种替代汽油中铅的抗爆剂。玛丽埃塔社区积极研究接触研究 (CARES) 是一项以社区为基础的研究，旨在探讨长期接触锰对儿童健康的影响。公众健康相关性：接触锰 (Mn) 会导致神经缺陷，而全球以 MMT 形式接触锰的潜力巨大，MMT 是一种替代汽油中铅的抗爆剂。玛丽埃塔社区积极研究接触研究 (CARES) 是一项以社区为基础的研究，旨在探讨长期接触锰对儿童健康的影响。