Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)

项目摘要 锰（Mn）在正常生长和发展中发挥着至关重要的作用社区积极 研究暴露研究（CARES）是建立在社区参与的研究实践。参与者 居住在全国环境锰含量最高的三个社区：玛丽埃塔和东利物浦，俄亥俄州， 和伊利诺斯州东南部的芝加哥。CARES队列由600多名儿童和他们的小学生组成。 照顾者，有两个时间点（7-9岁和13-17岁）广泛的神经发育 结果、暴露的生物标志物和家庭环境措施。关怀得到了以下方面的支持： 多个NIEHS资助的赠款，并已在下一代社区的培训工具- 从事环境健康科学工作十多年。该群体在以下方面发挥了重要作用： 开发用于血液金属评估的芯片实验室传感器，目前正在探索 通过磁共振成像对神经解剖学、功能、化学和生理学进行了研究。通过这个 项目，CARES研究团队将能够进行以下工作：目标1）保持 通过实施社区参与的研究策略来提高参与者的保留率;目的 2)扩展CARES，以加强整个生命周期内关键暴露窗口的表征，并评估 照顾者、儿童和社区水平的心理社会因素对毒物引起的 目标3）维持和加强生物储存库和数据管理 基础设施和开发实现数据共享方法。关怀是唯一一个准备 儿童和青少年环境锰暴露及其与脑功能关系研究 人口拟议的队列保留、增强和维护计划将加速和维持 CARES队列研究环境锰对神经发育结局影响的能力， 告知联邦政策有关环境暴露于锰，并作为一种宝贵的资源，为环境 健康科学培训生和科学家在地球仪。

PROJECT SUMMARY Manganese (Mn) plays an essential role in normal growth and development The Communities Actively Researching Exposure Study (CARES) was built upon community-engaged research practices. Participants reside in three communities with the nation's highest levels of ambient Mn: Marietta and East Liverpool, Ohio, and Southeast Side Chicago, Illinois. The CARES cohort consists of over 600 children and their primary caregiver, with two time-points (ages 7-9 years and ages 13-17 years) of extensive neurodevelopmental outcomes, biomarkers of exposure, and home environmental measures. The CARES has been supported by multiple NIEHS-funded grants and has been instrumental in the training of next generation community- engaged environmental health scientists for over a decade. The cohort has been instrumental in the development of a lab-on-a-chip sensor for blood metals assessment and is currently exploring the impact of Mn on neuroanatomy, function, chemistry, and physiology through magnetic resonance imaging. Through this project, the CARES research team will be able to conduct the following: Aim 1) Maintain the integrity of the CARES cohort by implementing community-engaged research strategies to improve participant retention; Aim 2) Expand CARES to enhance characterization of critical windows of exposure across the lifespan, and assess the role of caregiver, child, and community-level psychosocial factors on the etiology of toxicant-induced neurodevelopmental deficits; and Aim 3) Maintain and enhance biorepository and data management infrastructure and develop methods to implement data sharing. The CARES is the only cohort poised to investigate ambient exposure to Mn and its relationship to brain function in both a pediatric and adolescent population. The proposed cohort retention, enhancement, and maintenance plans will accelerate and sustain the ability of the CARES cohort to investigate the impact of ambient Mn on neurodevelopmental outcomes, inform federal polices related to ambient exposure to Mn, and serve as a valuable resource for environmental health science trainees and scientists across the globe.