Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)

项目总结 锰对社区的正常生长和发展起着至关重要的作用 研究性暴露研究(CARE)建立在社区参与研究实践的基础上。参与者 居住在全国环境锰水平最高的三个社区：玛丽埃塔和俄亥俄州东利物浦， 伊利诺伊州芝加哥东南部。CARE队列由600多名儿童和他们的主要 照顾者，有两个时间点(7-9岁和13-17岁)广泛的神经发育 结果、暴露的生物标记物和家庭环境措施。这些关爱活动得到了 NIEHS资助的多笔赠款，并在培训下一代社区方面发挥了重要作用- 与环境健康科学家合作了十多年。这群人在 开发一种用于血液金属评估的芯片实验室传感器，目前正在探索 MN通过磁共振成像对神经解剖、功能、化学和生理学的影响。通过这件事 项目之后，CARE研究团队将能够进行以下工作：目标1)维护 通过实施社区参与的研究战略来关注队列，以提高参与者留存率；目标 2)扩展CARE，以增强对整个生命周期内暴露的关键窗口的表征，并评估 照顾者、儿童和社区心理社会因素在毒物中毒病因学中的作用 神经发育缺陷；以及目标3)维护和加强生物信息库和数据管理 建立基础设施并制定实现数据共享的方法。关注者是唯一一群准备好 调查儿童和青少年环境中的锰暴露及其与脑功能的关系 人口。拟议的队列保留、增强和维护计划将加速并持续 CARE队列研究环境锰对神经发育结果的影响的能力， 告知联邦政策与环境中锰的暴露有关，并作为环境保护的宝贵资源 全球各地的健康科学实习生和科学家。

PROJECT SUMMARY Manganese (Mn) plays an essential role in normal growth and development The Communities Actively Researching Exposure Study (CARES) was built upon community-engaged research practices. Participants reside in three communities with the nation's highest levels of ambient Mn: Marietta and East Liverpool, Ohio, and Southeast Side Chicago, Illinois. The CARES cohort consists of over 600 children and their primary caregiver, with two time-points (ages 7-9 years and ages 13-17 years) of extensive neurodevelopmental outcomes, biomarkers of exposure, and home environmental measures. The CARES has been supported by multiple NIEHS-funded grants and has been instrumental in the training of next generation community- engaged environmental health scientists for over a decade. The cohort has been instrumental in the development of a lab-on-a-chip sensor for blood metals assessment and is currently exploring the impact of Mn on neuroanatomy, function, chemistry, and physiology through magnetic resonance imaging. Through this project, the CARES research team will be able to conduct the following: Aim 1) Maintain the integrity of the CARES cohort by implementing community-engaged research strategies to improve participant retention; Aim 2) Expand CARES to enhance characterization of critical windows of exposure across the lifespan, and assess the role of caregiver, child, and community-level psychosocial factors on the etiology of toxicant-induced neurodevelopmental deficits; and Aim 3) Maintain and enhance biorepository and data management infrastructure and develop methods to implement data sharing. The CARES is the only cohort poised to investigate ambient exposure to Mn and its relationship to brain function in both a pediatric and adolescent population. The proposed cohort retention, enhancement, and maintenance plans will accelerate and sustain the ability of the CARES cohort to investigate the impact of ambient Mn on neurodevelopmental outcomes, inform federal polices related to ambient exposure to Mn, and serve as a valuable resource for environmental health science trainees and scientists across the globe.