Center for Appalachian Research in Environmental Sciences

阿巴拉契亚环境科学研究中心

• 批准号: 10610031
• 负责人: Erin N Haynes
• 金额: $ 153万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610031
• 关键词: Acceleration; Address; Affect; Air; Air Pollution; Analytical Chemistry; Appalachian Region; Arsenic; Asthma; Bioinformatics; COVID-19 surveillance; Career Mobility; Chemicals; Chromium; Chronic Disease; Chronic Obstructive Pulmonary Disease; Clinical Data; Clinical Research; Coal Mining; Colorectal Cancer; Communication; Communities; Community Outreach; Complex; Core Facility; Data Science; Dedications; Diabetes Mellitus; Discipline; Disparity; Dissemination and Implementation; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollutants; Environmental Science; Exposure to; Faculty; Fostering; Foundations; Funding; Geology; Goals; Grant; Health; Health Promotion; Health Sciences; Heart; Heart Diseases; Incidence; Infrastructure; Joints; Kentucky; Knowledge; Lead; Learning; Life Style; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Medically Underserved Area; Mentors; Mentorship; Mission; Molecular Toxicology; Natural Gas; Nickel; Obesity; Oils; Particulate; Pilot Projects; Policies; Policy Developments; Population; Procedures; Process; Public Health; Radon; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Rural Appalachia; Science; Scientist; Services; Superfund; Trace Elements; Training; Translating; Translational Research; Universities; Water; Water Pollutants; air contaminant; base; career; career development; citizen science; clinical decision-making; community engaged research; community engagement; design; disease disparity; environmental justice; equity, diversity, and inclusion; experience; exposure pathway; health assessment; health communication; health disparity; health equity; health science research; improved; innovation; interest; member; multidisciplinary; novel; organic contaminant; outreach; population health; programs; research facility; research study; responsible research conduct; rural dwellers; skills; socioeconomic disadvantage; success; synergism; tobacco smoke exposure; translational pipeline; wastewater surveillance; water quality; waterborne

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will build on our early successes, capitalize on lessons learned, and enhance our mission through a dual focus on better understanding exposure pathways and emerging environmental health threats and optimizing research translation. Our Mission is to focus on exposure pathways to better match with community concerns and to emphasize research translation. Our Values reflect strong, multidirectional community-academic partnerships, with a renewed commitment to meaningful processes, procedures, and policies that respect and promote diversity, equity, and inclusivity. Responsible conduct of research is at the foundation of our Center, appreciating the essential value of rigorous and reproducible multidisciplinary team science. Our goals are to (a) advance multidisciplinary environmental health science (EHS); (b) analyze organic contaminants and trace- elements; (c) cultivate early-stage stage and established investigators; (d) learn with and from the community, helping to inform and translate our research; and (e) build science communication skills with investigators and community partners to boost research translation. We will advance EHS across the translational spectrum around three highly integrated science themes informed by residents of rural Appalachia: 1) Health Impacts of Waterborne Contaminants (WATER); 2) Health Impacts of Indoor and Outdoor Airborne Contaminants (AIR); and 3) Emerging Environmental Health Threats (EMERGING THREATS). The central hypothesis is that exposure to established contaminants via environmental exposure pathways (e.g., water, air) and emerging environmental health threats, combined with lifestyle and societal risk factors, contributes to the disproportionately high incidence of chronic diseases and health disparities in rural Appalachia. UK-CARES draws on a strong and diverse base of EHS and community-engaged research to meet the needs of communities in rural Appalachia. We will support and mentor investigators so they can reach the translational milestones in research: (1) asking fundamental questions; (2) applying and synthesizing; (3) implementing and adjusting; (4) moving ideas to practice; and (5) creating impact. In short, UK-CARES will leverage its resources to enhance EHS at UK while also reducing health risks and disparities in rural Appalachia. An Integrated Health Sciences Facility Core, Analytical Chemistry Core for Environmental Sciences, and Community Engagement Core are integral to this effort, as these cores will provide dedicated support in analytical chemistry, trace-elements analysis, biospecimen management, and bioinformatics and bridge Center and community priorities. The Pilot Project Program supports developing research and new scientific directions, advancing the careers of scientists interested in tackling challenging environmental health questions. UK- CARES will positively impact rural Appalachia through collaborative EHS designed to generate and disseminate new knowledge and translate research to inform clinical decision making and policy development.

项目概要-总体 肯塔基州大学阿巴拉契亚环境科学研究中心（UK-CARES）将 在我们早期成功的基础上，吸取经验教训，通过双重重点加强我们的使命， 更好地了解接触途径和新出现的环境健康威胁并优化研究 翻译.我们的使命是关注暴露途径，以更好地满足社区的关注， 强调研究翻译。我们的价值观反映了强大的，多方向的社区学术伙伴关系， 重新致力于有意义的流程，程序和政策，尊重和促进 多样性、公平性和包容性。负责任的研究行为是我们中心的基础， 欣赏严谨和可复制的多学科团队科学的基本价值。我们的目标是 (a)先进多学科环境健康科学（EHS）;（B）分析有机污染物和痕量- 要素;（c）培养早期阶段和成熟的调查人员;（d）与社区一起学习并向社区学习， 帮助为我们的研究提供信息和翻译;以及（e）培养与研究人员的科学交流技能， 社区合作伙伴促进研究翻译。我们将在整个平移范围内推进EHS 围绕着三个高度综合的科学主题，由阿巴拉契亚农村居民提供信息：1） 2）室内和室外空气传播污染物对健康的影响; 3）新出现的环境健康威胁（Emerging Threats）。核心假设是， 通过环境暴露途径暴露于已确定的污染物（例如，水、空气）和 环境健康威胁，加上生活方式和社会风险因素，导致 在阿巴拉契亚农村地区，慢性病发病率高得不成比例，健康差距大。联系我们 利用强大而多样化的EHS和社区参与研究基础，以满足 在阿巴拉契亚的农村社区。我们将支持和指导研究人员，使他们能够达到翻译 研究的里程碑：（1）提出基本问题;（2）应用和综合;（3）实施和 调整;（4）将想法付诸实践;（5）创造影响。简言之，UK-CARES将利用其资源 加强英国的EHS，同时减少阿巴拉契亚农村地区的健康风险和差距。集成 健康科学设施核心、环境科学分析化学核心和社区 Engagement Core是这项工作不可或缺的一部分，因为这些核心将在分析方面提供专门的支持， 化学，微量元素分析，生物标本管理，生物信息学和桥梁中心， 社区优先事项。试点项目计划支持发展研究和新的科学方向， 促进对解决具有挑战性的环境健康问题感兴趣的科学家的职业生涯。联合王国- CARES将积极影响农村阿巴拉契亚通过合作EHS旨在产生和 传播新知识并将研究成果转化为临床决策和政策制定的信息。

项目成果

Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane.

• DOI: 10.1016/j.taap.2018.06.003
• 发表时间: 2018-08-15
• 期刊: Toxicology and applied pharmacology
• 影响因子: 3.8
• 作者: Wang Y;Mandal AK;Son YO;Pratheeshkumar P;Wise JTF;Wang L;Zhang Z;Shi X;Chen Z
• 通讯作者: Chen Z

The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.

• DOI: 10.1002/mrd.23652
• 发表时间: 2022-12
• 期刊: MOLECULAR REPRODUCTION AND DEVELOPMENT
• 影响因子: 2.5
• 作者: Land, Katie L.;Miller, Frances G.;Fugate, Ava C.;Hannon, Patrick R.
• 通讯作者: Hannon, Patrick R.

Serum Cotinine versus Parent Reported Measures of Secondhand Smoke Exposure in Rural Appalachian Children.

• DOI: 10.13023/jah.0101.03
• 发表时间: 2019-01-01
• 期刊: Journal of Appalachian health
• 作者: Yeramaneni, Samrat;Yolton, Kimberly;Haynes, Erin N
• 通讯作者: Haynes, Erin N

Wastewater Surveillance for SARS-CoV-2 at Long-Term Care Facilities: Mixed Methods Evaluation.

• DOI: 10.2196/44657
• 发表时间: 2023-08-29
• 期刊: JMIR PUBLIC HEALTH AND SURVEILLANCE
• 影响因子: 8.5
• 作者: Keck, James W.;Lindner, Jess;Liversedge, Matthew;Mijatovic, Blazan;Olsson, Cullen;Strike, William;Noble, Anni;Adatorwovor, Reuben;Lacy, Parker;Smith, Ted;Berry, Scott M.
• 通讯作者: Berry, Scott M.

Stabilization of SARS-CoV-2 RNA in wastewater via rapid RNA extraction.

• DOI: 10.1016/j.scitotenv.2023.162992
• 发表时间: 2023-06-20
• 期刊: SCIENCE OF THE TOTAL ENVIRONMENT
• 影响因子: 9.8
• 作者: Torabi, Soroosh;Amirsoleimani, Atena;Banadaki, Mohammad Dehghan;Strike, William Dalton;Rockward, Alexus;Noble, Ann;Liversedge, Matthew;Keck, James W.;Berry, Scott M.
• 通讯作者: Berry, Scott M.