Center for Appalachian Research in Environmental Sciences

阿巴拉契亚环境科学研究中心

基本信息

批准号：
10610031
负责人：
Erin N Haynes
金额：
$ 153万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10610031
关键词：
Acceleration Address Affect Air Air Pollution Analytical Chemistry Appalachian Region Arsenic Asthma Bioinformatics COVID-19 surveillance Career Mobility Chemicals Chromium Chronic Disease Chronic Obstructive Pulmonary Disease Clinical Data Clinical Research Coal Mining Colorectal Cancer Communication Communities Community Outreach Complex Core Facility Data Science Dedications Diabetes Mellitus Discipline Disparity Dissemination and Implementation Environmental Exposure Environmental Health Environmental Impact Environmental Pollutants Environmental Science Exposure to Faculty Fostering Foundations Funding Geology Goals Grant Health Health Promotion Health Sciences Heart Heart Diseases Incidence Infrastructure Joints Kentucky Knowledge Lead Learning Life Style Malignant Neoplasms Malignant neoplasm of lung Measures Medically Underserved Area Mentors Mentorship Mission Molecular Toxicology Natural Gas Nickel Obesity Oils Particulate Pilot Projects Policies Policy Developments Population Procedures Process Public Health Radon Reproducibility Research Research Personnel Research Project Grants Resources Risk Risk Factors Rural Appalachia Science Scientist Services Superfund Trace Elements Training Translating Translational Research Universities Water Water Pollutants air contaminant base career career development citizen science clinical decision-making community engaged research community engagement design disease disparity environmental justice equity, diversity, and inclusion experience exposure pathway health assessment health communication health disparity health equity health science research improved innovation interest member multidisciplinary novel organic contaminant outreach population health programs research facility research study responsible research conduct rural dwellers skills socioeconomic disadvantage success synergism tobacco smoke exposure translational pipeline wastewater surveillance water quality waterborne

项目摘要

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will build on our early successes, capitalize on lessons learned, and enhance our mission through a dual focus on better understanding exposure pathways and emerging environmental health threats and optimizing research translation. Our Mission is to focus on exposure pathways to better match with community concerns and to emphasize research translation. Our Values reflect strong, multidirectional community-academic partnerships, with a renewed commitment to meaningful processes, procedures, and policies that respect and promote diversity, equity, and inclusivity. Responsible conduct of research is at the foundation of our Center, appreciating the essential value of rigorous and reproducible multidisciplinary team science. Our goals are to (a) advance multidisciplinary environmental health science (EHS); (b) analyze organic contaminants and trace- elements; (c) cultivate early-stage stage and established investigators; (d) learn with and from the community, helping to inform and translate our research; and (e) build science communication skills with investigators and community partners to boost research translation. We will advance EHS across the translational spectrum around three highly integrated science themes informed by residents of rural Appalachia: 1) Health Impacts of Waterborne Contaminants (WATER); 2) Health Impacts of Indoor and Outdoor Airborne Contaminants (AIR); and 3) Emerging Environmental Health Threats (EMERGING THREATS). The central hypothesis is that exposure to established contaminants via environmental exposure pathways (e.g., water, air) and emerging environmental health threats, combined with lifestyle and societal risk factors, contributes to the disproportionately high incidence of chronic diseases and health disparities in rural Appalachia. UK-CARES draws on a strong and diverse base of EHS and community-engaged research to meet the needs of communities in rural Appalachia. We will support and mentor investigators so they can reach the translational milestones in research: (1) asking fundamental questions; (2) applying and synthesizing; (3) implementing and adjusting; (4) moving ideas to practice; and (5) creating impact. In short, UK-CARES will leverage its resources to enhance EHS at UK while also reducing health risks and disparities in rural Appalachia. An Integrated Health Sciences Facility Core, Analytical Chemistry Core for Environmental Sciences, and Community Engagement Core are integral to this effort, as these cores will provide dedicated support in analytical chemistry, trace-elements analysis, biospecimen management, and bioinformatics and bridge Center and community priorities. The Pilot Project Program supports developing research and new scientific directions, advancing the careers of scientists interested in tackling challenging environmental health questions. UK- CARES will positively impact rural Appalachia through collaborative EHS designed to generate and disseminate new knowledge and translate research to inform clinical decision making and policy development.

项目摘要 - 总体肯塔基大学阿巴拉契亚环境科学研究中心（英国）将以我们的早期成功为基础，利用经验教训，并通过双重关注来增强我们的使命更好地了解曝光途径和新兴的环境健康威胁并优化研究翻译。我们的使命是专注于曝光途径，以更好地与社区关注和强调研究翻译。我们的价值反映了强大的多向社区学术伙伴关系，对尊重和促进的有意义的过程，程序和政策的重新承诺多样性，公平和包容性。负责任的研究是我们中心的基础欣赏严格且可重复的多学科团队科学的基本价值。我们的目标是（a）先进的多学科环境健康科学（EHS）；（b）分析有机污染物和痕量元素；（c）培养早期阶段和成熟的研究人员；（d）与社区一起学习，帮助告知和翻译我们的研究；（e）与调查员以及社区合作伙伴来增强研究翻译。我们将在翻译光谱中推进EHS 阿巴拉契亚农村居民告知的大约三个高度综合的科学主题：1）水上污染物（水）； 2）室内和室外空气污染物的健康影响（空气）； 3）新兴的环境健康威胁（新兴威胁）。中心假设是通过环境暴露途径（例如水，空气）和出现的环境暴露途径接触已建立的污染物环境健康威胁，再加上生活方式和社会风险因素，有助于阿巴拉契亚农村地区的慢性疾病和健康差异的不成比例高。英国 - 卡雷斯利用EHS和社区参与研究的强大而潜水的基础，以满足阿巴拉契亚粗糙的社区。我们将支持和指导调查员，以便他们能够达到翻译研究中的里程碑：（1）提出基本问题；（2）应用和合成；（3）实施和调整；（4）练习的想法；（5）产生影响。简而言之，英国 - 卡雷斯将利用其资源为了增强英国的EHS，同时还降低了阿巴拉契亚粗暴的健康风险和差异。一个集成的健康科学设施核心，环境科学的分析化学核心和社区参与核心是这项工作不可或缺的一部分，因为这些核心将为分析提供专门的支持化学，微量元素分析，生物测量管理以及生物信息学和桥梁中心以及社区优先事项。试点项目计划支持开发研究和新科学方向，促进有兴趣解决挑战环境健康问题的科学家的职业。英国- Cares将通过旨在产生和传播新知识并翻译研究，以告知临床决策和政策制定。

项目成果

期刊论文数量（45）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Serum Cotinine versus Parent Reported Measures of Secondhand Smoke Exposure in Rural Appalachian Children.

DOI：
10.13023/jah.0101.03
发表时间：
2019-01-01
期刊：
Journal of Appalachian health
影响因子：
0
作者：
Yeramaneni, Samrat;Yolton, Kimberly;Haynes, Erin N
通讯作者：
Haynes, Erin N

Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane.

DOI：
10.1016/j.taap.2018.06.003
发表时间：
2018-08-15
期刊：
Toxicology and applied pharmacology
影响因子：
3.8
作者：
Wang Y;Mandal AK;Son YO;Pratheeshkumar P;Wise JTF;Wang L;Zhang Z;Shi X;Chen Z
通讯作者：
Chen Z

The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.

DOI：
10.1002/mrd.23652
发表时间：
2022-12
期刊：
MOLECULAR REPRODUCTION AND DEVELOPMENT
影响因子：
2.5
作者：
Land, Katie L.;Miller, Frances G.;Fugate, Ava C.;Hannon, Patrick R.
通讯作者：
Hannon, Patrick R.

Wastewater Surveillance for SARS-CoV-2 at Long-Term Care Facilities: Mixed Methods Evaluation.

DOI：
10.2196/44657
发表时间：
2023-08-29
期刊：
JMIR PUBLIC HEALTH AND SURVEILLANCE
影响因子：
8.5
作者：
Keck, James W.;Lindner, Jess;Liversedge, Matthew;Mijatovic, Blazan;Olsson, Cullen;Strike, William;Noble, Anni;Adatorwovor, Reuben;Lacy, Parker;Smith, Ted;Berry, Scott M.
通讯作者：
Berry, Scott M.

Use of Theory-Driven Report Back to Promote Lung Cancer Risk Reduction.