Cannabis, HIV and Mental Processing Systems (CHAMPS)

大麻、艾滋病毒和心理处理系统 (CHAMPS)

基本信息

批准号：
10625336
负责人：
Beau M Ances
金额：
$ 58.84万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625336
关键词：
Affect Brain CCL2 gene CD14 gene CD8-Positive T-Lymphocytes CD8B1 gene Cannabidiol Cannabis Cellularity Classification Cognition Complex Counseling Cross-Sectional Studies Data Employment Encephalitis Exhibits Exposure to General Population HIV HIV Infections Health Hippocampus Immune Immunologic Markers Impaired cognition Inflammation Learning Legal Life Macrophage Measurement Measures Medical Marijuana Medicine Memory Methodology Methods Modeling Neopterin Neuropsychology Outcome Parietal Lobe Perforant Pathway Performance Peripheral Persons Pharmaceutical Preparations Phenotype Plasma Prevalence Prevention Guidelines Psyche structure Qualifying Recreational Drugs Reporting Research Design Sampling Science Short-Term Memory Structure Survival Rate System THC concentration Temporal Lobe Testing Tetrahydrocannabinol Urine Viral antiretroviral therapy cognitive performance data-driven model executive function high dimensionality immune activation immune function immune health improved indexing insight marijuana use marijuana user monocyte neuroimaging novel phenotypic data programs substance use treatment guidelines

项目摘要

ABSTRACT/PROJECT SUMMARY This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). Our overall hypothesis is that cannabis use leads to increases in inflammation in the peripheral and brain compartments. We also hypothesize that phenotypic signatures due to regular cannabis use and HIV will be delineated through NP and brain volumetrics. In Aim 1 we hypothesize that regular cannabis use will increase both peripheral and brain immune indices in PLWH on cART. In Aim 2 we hypothesize that regular cannabis use will lead to a worsening of NP and reductions in brain volumetrics in both PLWH on cART and HIV- controls. This proposal will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.

摘要/项目摘要该提案采用新颖的方法来识别并发艾滋病毒的关键决定因素和后果感染和常规大麻使用。我们将从外围和大脑中获取广泛的表型数据在生活的人中，免疫激活，大脑结构和神经心理学表现（NP）的标志艾滋病毒（PLWH）接受抗逆转录病毒疗法（CART）（80个常规大麻使用者和80个）非用户）和未感染的HIV（HIV-）对照（80个常规大麻使用者和80个非用户）。我们的整体假设是，大麻的使用导致外周和脑部室炎症增加。我们还假设，由于常规大麻使用而引起的表型特征将通过 NP和大脑体积。在AIM 1中，我们假设定期使用大麻会增加外围和脑袋中的脑免疫指标。在AIM 2中，我们假设定期使用大麻会导致 NP和艾滋病毒对照中的PLWH中的NP和脑体积减少的恶化。这个建议将提供有关常规大麻和艾滋病毒对外围和大脑标记的影响的关键见解 PLWH和HIV对照中的免疫功能和NP。这些见解对于治疗策略至关重要正在进行的艾滋病毒治疗计划。