THE ADMINISTRATION CORE (AC)

管理核心摘要 行政核心（AC）将支持老龄成人脑连接组（AABC）的整体工作， 建立一个有针对性的计划，确定影响大脑结构和功能轨迹的显著变量， 在生命周期中的连接性。顾问委员会会筹组资源，以支援这四个项目，以及 解决复原力和脆弱性因素的核心（例如遗传风险、环境压力、生活方式行为， 和绝经期），导致认知功能障碍、脑老化和阿尔茨海默病（AD）和Alz- 海默氏病相关性痴呆（ADRD）。AABC的AC将提供中央基础设施， 移植并扩展人类连接组老龄化项目（HCP-A）， 1000个人的数据。对于许多参与者来说，这将产生总共3-4个纵向时间 这将在8-10年内获得。AC将由华盛顿大学的联系PI Ances博士领导 在圣刘易斯（WUSTL），和一个执行领导小组的共同PI从每个四个数据采集点， 包括加州大学洛杉矶分校（UCLA）的布克海默博士，明尼苏达大学的特普斯特拉博士， 和马萨诸塞州总医院/哈佛大学（MGH）的Salat博士。此外该 AC包括一个由Babulal博士（WUSTL）和迪亚兹博士领导的新的多元化招聘和保留部门（DRRU）- 桑托斯（加州大学洛杉矶分校）。AC的目标包括：1）提供AABC的项目管理2）提供科学的 3）促进研究者、外部咨询委员会（EAC）之间的沟通， 和一般科学界。

ABSTRACT FOR ADMINISTRATIVE CORE The Administrative Core (AC) will support the overall work of the Aging Adult Brain Connectome (AABC) to establish a focused program that identifies salient variables that affect the trajectory of brain structural and func- tional connectivity during the lifespan. The AC will organize resources in support of the four Projects and four Cores that address resilience and vulnerability factors (e.g. genetic risk, environment stress, lifestyle behaviors, and menopause) that contribute to cognitive dysfunction, brain aging, and Alzheimer’s disease (AD) and Alz- heimer’s disease related dementias (ADRD). The AC of the AABC will provide the central infrastructure to sup- port and expand upon the Human Connectome Project for Aging (HCP-A) by continuing to collect longitudinal data from 1000 individuals across the lifespan. For many participants this will yield a total of 3-4 longitudinal time points that will be acquired over 8-10 years. The AC will be led by contact PI, Dr. Ances at Washington University in Saint Louis (WUSTL), and an Executive leadership team of co- PIs from each of four data acquisition sites, including Dr. Bookheimer at University of California Los Angeles (UCLA), Dr. Terpstra at the University of Min- nesota (UMinn), and Dr. Salat at Massachusetts General Hospital /Harvard University (MGH). In addition, the AC includes a new diversity recruitment and retention unit (DRRU) led by Drs. Babulal (WUSTL) and Diaz- Santos (UCLA). The aims of the AC include: 1) Provide program management of the AABC 2) Provide scientific direction for the AABC 3) Promote communication among investigators, the external advisory committee (EAC), and the general scientific community.