THE ADMINISTRATION CORE (AC)

行政核心摘要 行政核心(AC)将支持老龄成人脑连接组(AABC)的整体工作，以 建立一个有针对性的计划，确定影响大脑结构和功能轨迹的显著变量- 生命周期中的传统连通性。咨询委员会将组织资源支持这四个项目和四个 解决复原力和脆弱性因素(例如遗传风险、环境压力、生活方式行为、 和更年期)，导致认知功能障碍、大脑老化、阿尔茨海默病(AD)和阿尔茨海默病- 海默氏病相关痴呆(ADRD)。AABC的AC将提供中央基础设施，以支持- 通过继续收集纵向数据，移植和扩展人类衰老连接组项目(HCP-A) 数据来自1000个人的整个生命周期。对于许多参与者来说，这将产生总计3-4个纵向时间 将在8-10年内获得的积分。AC将由华盛顿大学的Contact Pi博士领导 在圣路易斯(WUSTL)，以及由来自四个数据采集点的共同PI组成的执行领导团队， 包括加州大学洛杉矶分校(UCLA)的布克海默博士，闽大学的特普斯特拉博士- 马萨诸塞州综合医院/哈佛大学(MGH)的Salat博士。此外， AC包括一个新的多样性招募和保留单位(DRRU)，由Bumulal博士(WUSTL)和Diaz- 桑托斯(加州大学洛杉矶分校)。AC的目标包括：1)提供AABC的项目管理2)提供科学的 3)促进调查人员、外部咨询委员会(EAC)、 和普通科学界。

ABSTRACT FOR ADMINISTRATIVE CORE The Administrative Core (AC) will support the overall work of the Aging Adult Brain Connectome (AABC) to establish a focused program that identifies salient variables that affect the trajectory of brain structural and func- tional connectivity during the lifespan. The AC will organize resources in support of the four Projects and four Cores that address resilience and vulnerability factors (e.g. genetic risk, environment stress, lifestyle behaviors, and menopause) that contribute to cognitive dysfunction, brain aging, and Alzheimer’s disease (AD) and Alz- heimer’s disease related dementias (ADRD). The AC of the AABC will provide the central infrastructure to sup- port and expand upon the Human Connectome Project for Aging (HCP-A) by continuing to collect longitudinal data from 1000 individuals across the lifespan. For many participants this will yield a total of 3-4 longitudinal time points that will be acquired over 8-10 years. The AC will be led by contact PI, Dr. Ances at Washington University in Saint Louis (WUSTL), and an Executive leadership team of co- PIs from each of four data acquisition sites, including Dr. Bookheimer at University of California Los Angeles (UCLA), Dr. Terpstra at the University of Min- nesota (UMinn), and Dr. Salat at Massachusetts General Hospital /Harvard University (MGH). In addition, the AC includes a new diversity recruitment and retention unit (DRRU) led by Drs. Babulal (WUSTL) and Diaz- Santos (UCLA). The aims of the AC include: 1) Provide program management of the AABC 2) Provide scientific direction for the AABC 3) Promote communication among investigators, the external advisory committee (EAC), and the general scientific community.