THE ADMINISTRATION CORE (AC)

管理核心 (AC)

• 批准号: 10283064
• 负责人: Beau M Ances
• 金额: $ 73.84万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283064
• 关键词: Address; Adult; Advisory Committees; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ancillary Study; Behavior; Blood; Brain; California; Centenarian; Clinical; Collaborations; Communication; Communities; Consult; Data; Data Analyses; Decision Making; Development; Elderly; Ensure; Environment; Evaluation; General Hospitals; Genetic; Genetic Risk; Goals; Health; Human; Impaired cognition; Individual; Informatics; Infrastructure; Institution; Leadership; Life Style; Longevity; Los Angeles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Massachusetts; Menopause; Minnesota; Monitor; Neurocognitive; Neuropsychology; Participant; Pathologic; Phase Transition; Phenotype; Physical activity; Physiological; Progress Reports; Research Personnel; Resistance; Resources; Saints; Site; Specimen; Stress; Structure; Symptoms; Teleconferences; Time; Training; Underrepresented Populations; United States National Institutes of Health; Universities; Vasomotor; Washington; Work; aged; aging brain; allostatic load; cohort; connectome; data acquisition; data integration; data management; meetings; middle age; multiple omics; neuroimaging; programs; recruit; relating to nervous system; resilience; senescence; statistics

ABSTRACT FOR ADMINISTRATIVE CORE The Administrative Core (AC) will support the overall work of the Aging Adult Brain Connectome (AABC) to establish a focused program that identifies salient variables that affect the trajectory of brain structural and func- tional connectivity during the lifespan. The AC will organize resources in support of the four Projects and four Cores that address resilience and vulnerability factors (e.g. genetic risk, environment stress, lifestyle behaviors, and menopause) that contribute to cognitive dysfunction, brain aging, and Alzheimer’s disease (AD) and Alz- heimer’s disease related dementias (ADRD). The AC of the AABC will provide the central infrastructure to sup- port and expand upon the Human Connectome Project for Aging (HCP-A) by continuing to collect longitudinal data from 1000 individuals across the lifespan. For many participants this will yield a total of 3-4 longitudinal time points that will be acquired over 8-10 years. The AC will be led by contact PI, Dr. Ances at Washington University in Saint Louis (WUSTL), and an Executive leadership team of co- PIs from each of four data acquisition sites, including Dr. Bookheimer at University of California Los Angeles (UCLA), Dr. Terpstra at the University of Min- nesota (UMinn), and Dr. Salat at Massachusetts General Hospital /Harvard University (MGH). In addition, the AC includes a new diversity recruitment and retention unit (DRRU) led by Drs. Babulal (WUSTL) and Diaz- Santos (UCLA). The aims of the AC include: 1) Provide program management of the AABC 2) Provide scientific direction for the AABC 3) Promote communication among investigators, the external advisory committee (EAC), and the general scientific community.

行政核心摘要